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Scientific paper - Review paper
Reactive and Clonal Thrombocytosis: Cytokines and Acute Phase Reactants
Acta clinica Croatica, 43 (2004), 1; 97-102. urn:nbn:hr:220:247701
Fodor-Alagić, Ljiljana; Stančić, Vladimir; Gaćina, Petar; Čaržavec, Dubravka; Nikolić-Heitzler, Vjeran; Planinc, Danijel; Štambuk, Krešimir; Bonić, Ivan; Car, Boris; Solter, Miljenko; Vitezić-Misjak, Mira; Bečejac, Branko; Altabas, Velimir

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Fodor Alagić, Lj., Stančić, V., Gaćina, P., Čaržavec, D., Nikolić Heitzler, V., Planinc, D. ... Altabas, V. (2004). Reactive and Clonal Thrombocytosis: Cytokines and Acute Phase Reactants. Acta clinica Croatica, 43. (1), 97-102. Retrieved from https://urn.nsk.hr/urn:nbn:hr:220:247701

Fodor Alagić, Ljiljana, et al. "Reactive and Clonal Thrombocytosis: Cytokines and Acute Phase Reactants." Acta clinica Croatica, vol. 43, no. 1, 2004, pp. 97-102. https://urn.nsk.hr/urn:nbn:hr:220:247701

Fodor Alagić, Ljiljana, Vladimir Stančić, Petar Gaćina, Dubravka Čaržavec, Vjeran Nikolić Heitzler, Danijel Planinc, Krešimir Štambuk, et al. "Reactive and Clonal Thrombocytosis: Cytokines and Acute Phase Reactants." Acta clinica Croatica 43, no. 1 (2004): 97-102. https://urn.nsk.hr/urn:nbn:hr:220:247701

Fodor Alagić, Lj., et al. (2004) 'Reactive and Clonal Thrombocytosis: Cytokines and Acute Phase Reactants', Acta clinica Croatica, 43(1), pp. 97-102. Available at: https://urn.nsk.hr/urn:nbn:hr:220:247701 (Accessed 21 April 2024)

Fodor Alagić Lj, Stančić V, Gaćina P, Čaržavec D, Nikolić Heitzler V, Planinc D, and sur.. Reactive and Clonal Thrombocytosis: Cytokines and Acute Phase Reactants. Acta clinica Croatica [Internet]. 2004 [cited 2024 April 21];43(1):97-102. Available at: https://urn.nsk.hr/urn:nbn:hr:220:247701

Lj. Fodor Alagić, et al., "Reactive and Clonal Thrombocytosis: Cytokines and Acute Phase Reactants", Acta clinica Croatica, vol. 43, no. 1, pp. 97-102, 2004. [Online]. Available at: https://urn.nsk.hr/urn:nbn:hr:220:247701. [Accessed: 21 April 2024]

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Metadata
Title (english)Reactive and Clonal Thrombocytosis: Cytokines and Acute Phase Reactants
Title (croatian)Reaktivna i klonska trombocitoza: citokini i reaktanti akutne faze
AuthorLjiljana Fodor-Alagić
AuthorVladimir Stančić
AuthorPetar Gaćina
AuthorDubravka Čaržavec
AuthorVjeran Nikolić-Heitzler
AuthorDanijel Planinc
AuthorKrešimir Štambuk
AuthorIvan Bonić
AuthorBoris Car
AuthorMiljenko Solter
AuthorMira Vitezić-Misjak
AuthorBranko Bečejac
AuthorVelimir Altabas
Author's institution(Sestre milosrdnice University Hospital Center)
Scientific / art field,
discipline and subdiscipline		BIOMEDICINE AND HEALTHCARE
Clinical Medical Sciences
Internal Medicine
Abstract (english)
Platelets are acute phase reactants that increase in response to various stimuli, including systemic infections, inflammatory conditions, bleeding, and tumors. This is called reactive or secondary thrombocytosis, which is a benign form of thrombocytosis. Clonal thrombocytosis is an unregulated abnormality of platelet production due to clonal expansion of bone marrow progenitor cells. Secondary thrombocytosis may be due to the overproduction of proinflammatory cytokines such as interleukin-1 (IL-1), IL-6, and IL-11, which occurs in chronic inflammatory, infectious and malignant states. The presence of elevated IL-1, IL-6, C-reactive protein and granulocyte-macrophage colony-stimulating factor in individuals with this condition suggests that these cytokines may be involved in reactive thrombocytosis.
Abstract (croatian)
Trombociti su reaktanti akutne faze i njihov se broj povećava kao odgovor na različite podražaje, uključujući sistemske infekcije, upalna stanja, krvarenja i tumore. To se naziva reaktivnom ili sekundarnom trombocitozom, što je benigni oblik trombocitoze. Esencijalna trombocitoza je nenormalna proizvodnja trombocita uzrokovana klonskom ekspanzijom progenitorske stanice koštane srži. Sekundarna trombocitoza može biti uzrokovana prekomjernom proizvodnjom proupalnih citokina, kao što su interleukin 1 (IL-1), IL-6, IL-11, koji se javljaju u kroničnim upalnim, infektivnim i malignim stanjima. Prisutnost povišenih vrijednosti IL-1, IL-6, C-reaktivnog proteina i granulocitno-makrofagnog faktora stimulacije rasta u pojedinaca s ovim stanjem ukazuje kako bi ovi citokini mogli biti upleteni u reaktivnu trombocitozu.
Keywords (english)
Keywords (croatian)
Languageenglish
Languagecroatian
Publication typeScientific paper - Review paper
Publication statusPublished
Peer reviewPeer review - international
Publication versionPublished version
Journal titleActa clinica Croatica
Numberingvol. 43, no. 1, pp. 97-102
p-ISSN0353-9466
e-ISSN1333-9451
URN:NBNurn:nbn:hr:220:247701
Publication2004
Document URLhttps://hrcak.srce.hr/14449
Type of resourceText
Access conditionsOpen access
Terms of useLicence Attribution-NonCommercial-NoDerivatives 4.0 International (CC BY-NC-ND 4.0) icon
Created on2023-01-16 11:26:11