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Scientific paper - Original scientific paper
The Association of Subclinical Insulin Resistance with Thyroid Autoimmunity in Euthyroid Individuals
Acta clinica Croatica, 59. (2020), 4.; 696-702. https://doi.org/10.20471/acc.2020.59.04.16
Blaslov, Kristina; Gajski, Domagoj; Vucelić, Vesna; Gaćina, Petar; Mirošević, Gorana; Marinković, Jelena; Vrkljan, Milan; Rotim, Krešimir

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Blaslov, K., Gajski, D., Vucelić, V., Gaćina, P., Mirošević, G., Marinković, J. ... Rotim, K. (2020). The Association of Subclinical Insulin Resistance with Thyroid Autoimmunity in Euthyroid Individuals. Acta clinica Croatica, 59.. (4.), 696-702. doi: 10.20471/acc.2020.59.04.16

Blaslov, Kristina, et al. "The Association of Subclinical Insulin Resistance with Thyroid Autoimmunity in Euthyroid Individuals." Acta clinica Croatica, vol. 59., no. 4., 2020, pp. 696-702. https://doi.org/10.20471/acc.2020.59.04.16

Blaslov, Kristina, Domagoj Gajski, Vesna Vucelić, Petar Gaćina, Gorana Mirošević, Jelena Marinković, Milan Vrkljan and Krešimir Rotim. "The Association of Subclinical Insulin Resistance with Thyroid Autoimmunity in Euthyroid Individuals." Acta clinica Croatica 59., no. 4. (2020): 696-702. https://doi.org/10.20471/acc.2020.59.04.16

Blaslov, K., et al. (2020) 'The Association of Subclinical Insulin Resistance with Thyroid Autoimmunity in Euthyroid Individuals', Acta clinica Croatica, 59.(4.), pp. 696-702. doi: 10.20471/acc.2020.59.04.16

Blaslov K, Gajski D, Vucelić V, Gaćina P, Mirošević G, Marinković J, and sur.. The Association of Subclinical Insulin Resistance with Thyroid Autoimmunity in Euthyroid Individuals. Acta clinica Croatica [Internet]. 2020 [cited 2024 December 08];59.(4.):696-702. doi: 10.20471/acc.2020.59.04.16

K. Blaslov, et al., "The Association of Subclinical Insulin Resistance with Thyroid Autoimmunity in Euthyroid Individuals", Acta clinica Croatica, vol. 59., no. 4., pp. 696-702, 2020. [Online]. Available at: https://urn.nsk.hr/urn:nbn:hr:220:789678. [Accessed: 08 December 2024]

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Metadata
Title (english)The Association of Subclinical Insulin Resistance with Thyroid Autoimmunity in Euthyroid Individuals
Title (croatian)Povezanost subkliničke inzulinske rezistencije a autoimunim biljezima štitne žlijezde u eutiroidnih ispitanika
AuthorKristina Blaslov
AuthorDomagoj Gajski
AuthorVesna Vucelić
AuthorPetar Gaćina
AuthorGorana Mirošević
AuthorJelena Marinković
AuthorMilan Vrkljan
AuthorKrešimir Rotim
Author's institution(Sestre milosrdnice University Hospital Center)
Scientific / art field,
discipline and subdiscipline		BIOMEDICINE AND HEALTHCARE
Clinical Medical Sciences
Internal Medicine
Abstract (english)
Hashimoto thyroiditis is characterized by anti-thyroid peroxidase (anti-TPO) and anti-thyroglobulin (anti-Tg) antibodies that gradually lead to thyroid cell destruction. As hypothyroidism has been associated with insulin resistance (IR), we aimed to investigate whether IR is associated with thyroid antibody presence and whether the degree of IR correlates with their concentration in euthyroid individuals. A total of 164 non-diabetic, euthyroid individuals, average age 34 years, were included in the study, divided into two groups according to Hashimoto thyroiditis and underwent 5-hour oral glucose tolerance test. The degree of IR was evaluated by the Homeostatic Model Assessment of Insulin Resistance (HOMA-IR). The Hashimoto thyroiditis group had higher HOMA-IR (p=0.003) and lower glucose levels (p=0.04). HOMA-IR correlated positively with anti-TPO (p<0.001). Linear logistic regression revealed that anti-TPO concentration increased by 18.13 (p=0.001) with each HOMA-IR unit. IR might trigger thyroid antibody production and Hashimoto thyroiditis development, which needs to be evaluated in further larger scale follow up studies.
Abstract (croatian)
Hashimotov tireoidits obilježavaju anti-TPO i anti-Tg antitijela koja postupno dovode do uništenja stanica štitne žlijezde. Kako se hipotireoza povezuje s inzulinskom rezistencijom (IR) cilj ovoga istraživanja bio je ispitati postoji li povezanost IR s prisutnošću tireoidnih antitijela te je li stupanj IR povezan s koncentracijom autoantitijela u eutiroidnih ispitanika. U istraživanje je bilo uključeno 164 eutiroidnih ispitanika bez šećerne bolesti koji su podijeljeni u dvije skupine ovisno o prisutnosti Hashimotova tireoiditisa. Svi ispitanici podvrgnuti su 5-satnom testu opterećenja glukozom. Stupanj IR izračunat je standardiziranom metodom HOMA-IR (engl. Homeostatic Model Assessment of Insulin Resistance). Skupina ispitanika s Hashimotovim tireoiditisom imala je više vrijednosti HOMA-IR (p=0,003), ali i nižu koncentraciju glukoze (p=0,04). HOMA-IR pozitivno je korelirao s anti-TPO (p<0,001). Linearna logistička regresija pokazala je da koncentracija anti-TPO poraste za 18,13 (p=0,001) sa svakom jedinicom porasta HOMA-IR. IR je mogući okidač za razvoj autoantitijela štitnjače i razvoj Hashimotove bolesti, što treba evaluirati u budućim prospektivnim istraživanjima.
Keywords (english)
Keywords (croatian)
Languageenglish
Languagecroatian
Publication typeScientific paper - Original scientific paper
Publication statusPublished
Peer reviewPeer review - international
Publication versionPublished version
Journal titleActa clinica Croatica
Numberingvol. 59., no. 4., pp. 696-702
p-ISSN0353-9466
e-ISSN1333-9451
DOIhttps://doi.org/10.20471/acc.2020.59.04.16
URN:NBNurn:nbn:hr:220:789678
Publication2020
Document URLhttps://hrcak.srce.hr/254883
Type of resourceText
Access conditionsOpen access
Terms of useLicence In copyright icon
Created on2023-06-05 12:05:04