prikaz prve stranice dokumenta Choroidal Neovascularization in Age-Related Macular Degeneration Treated with Photodynamic Therapy and Intravitreal Triamcinolone Acetonide
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Choroidal Neovascularization in Age-Related Macular Degeneration Treated with Photodynamic Therapy and Intravitreal Triamcinolone Acetonide
Acta clinica Croatica, 46 (2007), 2; 161-165. urn:nbn:hr:220:072530
Vrabec, Romano; Vatavuk, Zoran; Benčić, Goran; Čima, Ivan; Zrinšćak, Ognjen; Mandić, Zdravko

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Vrabec, R., Vatavuk, Z., Benčić, G., Čima, I., Zrinšćak, O. & Mandić, Z. (2007). Choroidal Neovascularization in Age-Related Macular Degeneration Treated with Photodynamic Therapy and Intravitreal Triamcinolone Acetonide. Acta clinica Croatica, 46. (2), 161-165. Retrieved from https://urn.nsk.hr/urn:nbn:hr:220:072530

Vrabec, Romano, et al. "Choroidal Neovascularization in Age-Related Macular Degeneration Treated with Photodynamic Therapy and Intravitreal Triamcinolone Acetonide." Acta clinica Croatica, vol. 46, no. 2, 2007, pp. 161-165. https://urn.nsk.hr/urn:nbn:hr:220:072530

Vrabec, Romano, Zoran Vatavuk, Goran Benčić, Ivan Čima, Ognjen Zrinšćak and Zdravko Mandić. "Choroidal Neovascularization in Age-Related Macular Degeneration Treated with Photodynamic Therapy and Intravitreal Triamcinolone Acetonide." Acta clinica Croatica 46, no. 2 (2007): 161-165. https://urn.nsk.hr/urn:nbn:hr:220:072530

Vrabec, R., et al. (2007) 'Choroidal Neovascularization in Age-Related Macular Degeneration Treated with Photodynamic Therapy and Intravitreal Triamcinolone Acetonide', Acta clinica Croatica, 46(2), pp. 161-165. Available at: https://urn.nsk.hr/urn:nbn:hr:220:072530 (Accessed 10 May 2024)

Vrabec R, Vatavuk Z, Benčić G, Čima I, Zrinšćak O, Mandić Z. Choroidal Neovascularization in Age-Related Macular Degeneration Treated with Photodynamic Therapy and Intravitreal Triamcinolone Acetonide. Acta clinica Croatica [Internet]. 2007 [cited 2024 May 10];46(2):161-165. Available at: https://urn.nsk.hr/urn:nbn:hr:220:072530

R. Vrabec, Z. Vatavuk, G. Benčić, I. Čima, O. Zrinšćak and Z. Mandić, "Choroidal Neovascularization in Age-Related Macular Degeneration Treated with Photodynamic Therapy and Intravitreal Triamcinolone Acetonide", Acta clinica Croatica, vol. 46, no. 2, pp. 161-165, 2007. [Online]. Available at: https://urn.nsk.hr/urn:nbn:hr:220:072530. [Accessed: 10 May 2024]

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Title (english)Choroidal Neovascularization in Age-Related Macular Degeneration Treated with Photodynamic Therapy and Intravitreal Triamcinolone Acetonide
Title (croatian)Koroidna neovaskularizacija kod makularne degeneracije povezane s dobi liječene fotodinamskom terapijom i intravitrealnim triamcinolon acetonidom
AuthorRomano Vrabec
AuthorZoran Vatavuk
AuthorGoran Benčić
AuthorIvan Čima
AuthorOgnjen Zrinšćak
AuthorZdravko Mandić
Author's institution(Sestre milosrdnice University Hospital Center)
Scientific / art field,
discipline and subdiscipline		BIOMEDICINE AND HEALTHCARE
Clinical Medical Sciences
Ophthalmology
Abstract (english)
The aim of the study was to show the effect of combined photodynamic therapy and intravitreal injection of triamcinolone acetonide in the treatment of choroidal neovascularization due to age-related macular degeneration. This retrospective, nonrandomized study included 20 patients with predominantly classic choroidal neovascularization due to age-related macular degeneration with no prior treatment. At baseline, all patients underwent ophthalmologic examination. Fluorescein angiography and optical coherent tomography were performed and analyzed. Triamcinolone acetonide, 4 mg, was intravitreally applied at 24-48 hours after standard photodynamic therapy. Follow up was scheduled at 3, 6 and 9 months. After 9 months, visual acuity improved in four, remained unchanged in 14 and decreased in two patients. In all patients, complete closure of choroidal neovascularization occurred after 9 months. At that time, a decrease in the central foveal thickness was also recorded in all patients. Combined photodynamic therapy and intravitreal injection of triamcinolone acetonide is a safe method in the treatment of choroidal neovascularization due to age-related macular degeneration, and leads to complete closure of choroidal neovascularization. To prove these promising results, a carefully designed, randomized, controlled study in a larger group of patients is needed.
Abstract (croatian)
Prikazuju se rezultati kombinirane intravitrealne primjene triamcinolona i fotodinamske terapije kod razvoja koroidnih neovaskularizacija koje su nastale kao posljedica senilne makularne degeneracije. U retrospektivnu nerandomiziranu studiju bilo je uključeno 20 bolesnika s pretežito klasičnom koroidnom neovaskularizacijom, koji do tada nisu bili liječeni. Kod svih bolesnika učinjen je standardni oftalmološki pregled, fluoresceinska angiografija i optička koherentna tomografija. Triamcinolon acetonid, 4 mg, apliciran je intravitrealno 24-48 sati nakon fotodinamske terapije. Praćenje bolesnika je provedeno nakon 3, 6 i 9 mjeseci. Nakon 9 mjeseci kod 4 bolesnika došlo je do poboljšanja vidne oštrine, kod 14 bolesnika vidna oštrina je ostala stabilna, dok je kod 2 bolesnika zabilježen pad vidne oštrine. Potpun nestanak koroidne neovaskularizacije kod svih je bolesnika zabilježen nakon 9 mjeseci. Kombinirana primjena triamcinolona i fotodinamske terapije sigurna je metoda u liječenju pretežito klasičnih koroidnih neovaskularizacija, koja dovodi do njihovog potpunog zatvaranja i nestajanja, no za potvrdu ovih rezultata potrebna je randomizirana analiza na većem broju bolesnika.
Keywords (english)
Keywords (croatian)
Languageenglish
Languagecroatian
Publication typeProfessional paper - Professional paper
Publication statusPublished
Peer reviewPeer review - international
Publication versionPublished version
Journal titleActa clinica Croatica
Numberingvol. 46, no. 2, pp. 161-165
p-ISSN0353-9466
e-ISSN1333-9451
URN:NBNurn:nbn:hr:220:072530
Publication2007
Document URLhttps://hrcak.srce.hr/13622
Type of resourceText
Access conditionsOpen access
Terms of useLicence Attribution-NonCommercial-NoDerivatives 4.0 International (CC BY-NC-ND 4.0) icon
Created on2023-11-13 08:16:33