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Scientific paper - Original scientific paper
The Concentration of Interleukin 6 and Tumor Necrosis Factor Alpha in Saliva and Blood of Patients with Inactive Multiple Sclerosis And Coexisting Hashimoto’s Thyroiditis
Acta clinica Croatica, 62. (2023), 2; 339-344. https://doi.org/10.20471/acc.2023.62.02.12
Šiško Markoš, Ines; Franceschi, Maja; Vidranski, Valentina; Markoš, Pave; Jukić, Tomislav; Fröbe, Ana; Bašić Kes, Vanja

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Šiško Markoš, I., Franceschi, M., Vidranski, V., Markoš, P., Jukić, T., Fröbe, A. & Bašić Kes, V. (2023). The Concentration of Interleukin 6 and Tumor Necrosis Factor Alpha in Saliva and Blood of Patients with Inactive Multiple Sclerosis And Coexisting Hashimoto’s Thyroiditis. Acta clinica Croatica, 62.. (2), 339-344. doi: 10.20471/acc.2023.62.02.12

Šiško Markoš, Ines, et al. "The Concentration of Interleukin 6 and Tumor Necrosis Factor Alpha in Saliva and Blood of Patients with Inactive Multiple Sclerosis And Coexisting Hashimoto’s Thyroiditis." Acta clinica Croatica, vol. 62., no. 2, 2023, pp. 339-344. https://doi.org/10.20471/acc.2023.62.02.12

Šiško Markoš, Ines, Maja Franceschi, Valentina Vidranski, Pave Markoš, Tomislav Jukić, Ana Fröbe and Vanja Bašić Kes. "The Concentration of Interleukin 6 and Tumor Necrosis Factor Alpha in Saliva and Blood of Patients with Inactive Multiple Sclerosis And Coexisting Hashimoto’s Thyroiditis." Acta clinica Croatica 62., no. 2 (2023): 339-344. https://doi.org/10.20471/acc.2023.62.02.12

Šiško Markoš, I., et al. (2023) 'The Concentration of Interleukin 6 and Tumor Necrosis Factor Alpha in Saliva and Blood of Patients with Inactive Multiple Sclerosis And Coexisting Hashimoto’s Thyroiditis', Acta clinica Croatica, 62.(2), pp. 339-344. doi: 10.20471/acc.2023.62.02.12

Šiško Markoš I, Franceschi M, Vidranski V, Markoš P, Jukić T, Fröbe A, and sur.. The Concentration of Interleukin 6 and Tumor Necrosis Factor Alpha in Saliva and Blood of Patients with Inactive Multiple Sclerosis And Coexisting Hashimoto’s Thyroiditis. Acta clinica Croatica [Internet]. 2023 [cited 2024 November 18];62.(2):339-344. doi: 10.20471/acc.2023.62.02.12

I. Šiško Markoš, et al., "The Concentration of Interleukin 6 and Tumor Necrosis Factor Alpha in Saliva and Blood of Patients with Inactive Multiple Sclerosis And Coexisting Hashimoto’s Thyroiditis", Acta clinica Croatica, vol. 62., no. 2, pp. 339-344, 2023. [Online]. Available at: https://urn.nsk.hr/urn:nbn:hr:220:155024. [Accessed: 18 November 2024]

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Title (english)The Concentration of Interleukin 6 and Tumor Necrosis Factor Alpha in Saliva and Blood of Patients with Inactive Multiple Sclerosis And Coexisting Hashimoto’s Thyroiditis
Title (croatian)Koncentracija interleukina 6 i faktora tumorske nekroze alfa u slini i krvi bolesnika s neaktivnom multiplom sklerozom i supostojećim Hashimotovim tireoiditisom
AuthorInes Šiško Markoš
AuthorMaja Franceschi
AuthorValentina Vidranski
AuthorPave Markoš
AuthorTomislav Jukić
AuthorAna Fröbe
AuthorVanja Bašić Kes
Author's institution(Sestre milosrdnice University Hospital Center)
Scientific / art field,
discipline and subdiscipline		BIOMEDICINE AND HEALTHCARE
Clinical Medical Sciences
Nuclear Medicine
Abstract (english)
The concentration of interleukin 6 (IL-6) and tumor necrosis factor alpha (TNF-α) in the blood is higher in patients with active multiple sclerosis (MS) compared to those with inactive disease. The concentration of IL-6 and TNF-α in the blood is higher in patients with Hashimoto’s thyroiditis (HT) compared to those with a healthy thyroid. The aim of the study was to assess whether serum IL-6 and TNF-α levels correlated with saliva in patients with inactive MS and whether there was a difference in these groups of patients depending of thyroid status. We also examined the correlation of thyroid stimulating hormone (TSH) levels with thyroid status. The study included 54 patients in the inactive phase of MS. The level of cytokines in the blood was determined by chemiluminescence, and in saliva by ELISA. Blood and saliva IL-6 levels showed positive correlation, while blood and saliva TNF-α levels were not correlated. There was a significantly higher TSH level in patients with inactive MS with positive thyroid antibodies, without therapy, compared with those with negative antibodies.
Abstract (croatian)
Koncentracija interleukina 6 (IL-6) i faktora tumorske nekroze alfa (TNF-α) u krvi je veća u bolesnika s aktivnom multiplom sklerozom (MS) u odnosu na one s neaktivnom bolešću. Koncentracija IL-6 i TNF-α u krvi je veća kod bolesnika s Hashimotovim tireoditisom (HT) u odnosu na one sa zdravom štitnjačom. Cilj istraživanja bio je procijeniti koreliraju li serumske razine IL-6 i TNF-α s onima u slini kod bolesnika s neaktivnom MS i postoji li razlika među navedenim skupinama bolesnika ovisno o statusu štitnjače. Također smo ispitali korelaciju razine tireoidnog stimulirajućeg hormona (TSH) sa statusom štitnjače kod svih bolesnika. U istraživanje su uključena 54 bolesnika u neaktivnoj fazi MS. Razina citokina u krvi je određena metodom kemiluminiscencije, a u slini metodom ELISA. Pozitivno je korelirala razina IL-6 u krvi i slini, dok razina TNF-α u krvi i slini nije korelirala. Značajno je veća bila razina TSH u bolesnika s neaktivnom MS s pozitivnim protutijelima na štitnjaču, bez terapije, u odnosu na one s negativnim protutijelima.
Keywords (english)
Keywords (croatian)
Languageenglish
Languagecroatian
Publication typeScientific paper - Original scientific paper
Publication statusPublished
Peer reviewPeer review - international
Publication versionPublished version
Journal titleActa clinica Croatica
Numberingvol. 62., no. 2, pp. 339-344
p-ISSN0353-9466
e-ISSN1333-9451
DOIhttps://doi.org/10.20471/acc.2023.62.02.12
URN:NBNurn:nbn:hr:220:155024
Publication2023
Document URLhttps://hrcak.srce.hr/308766
Type of resourceText
Access conditionsOpen access
Terms of useLicence In copyright icon
Created on2024-06-17 11:20:32