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Scientific paper - Original scientific paper
Factors Affecting Outcome in the Treatment of Glioblastoma
Acta clinica Croatica, 60 (2021), 3; 373-378. https://doi.org/10.20471/acc.2021.60.03.06
Koruga, Nenad; Pekmezović, Tatjana; Tomaš, Ilijan; Soldo Koruga, Anamarija; Butković Soldo, Silva; Užarević, Zvonimir; Rotim, Krešimir

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Koruga, N., Pekmezović, T., Tomaš, I., Soldo Koruga, A., Butković Soldo, S., Užarević, Z. & Rotim, K. (2021). Factors Affecting Outcome in the Treatment of Glioblastoma. Acta clinica Croatica, 60. (3), 373-378. doi: 10.20471/acc.2021.60.03.06

Koruga, Nenad, et al. "Factors Affecting Outcome in the Treatment of Glioblastoma." Acta clinica Croatica, vol. 60, no. 3, 2021, pp. 373-378. https://doi.org/10.20471/acc.2021.60.03.06

Koruga, Nenad, Tatjana Pekmezović, Ilijan Tomaš, Anamarija Soldo Koruga, Silva Butković Soldo, Zvonimir Užarević and Krešimir Rotim. "Factors Affecting Outcome in the Treatment of Glioblastoma." Acta clinica Croatica 60, no. 3 (2021): 373-378. https://doi.org/10.20471/acc.2021.60.03.06

Koruga, N., et al. (2021) 'Factors Affecting Outcome in the Treatment of Glioblastoma', Acta clinica Croatica, 60(3), pp. 373-378. doi: 10.20471/acc.2021.60.03.06

Koruga N, Pekmezović T, Tomaš I, Soldo Koruga A, Butković Soldo S, Užarević Z, and sur.. Factors Affecting Outcome in the Treatment of Glioblastoma. Acta clinica Croatica [Internet]. 2021 [cited 2024 December 31];60(3):373-378. doi: 10.20471/acc.2021.60.03.06

N. Koruga, et al., "Factors Affecting Outcome in the Treatment of Glioblastoma", Acta clinica Croatica, vol. 60, no. 3, pp. 373-378, 2021. [Online]. Available at: https://urn.nsk.hr/urn:nbn:hr:220:706285. [Accessed: 31 December 2024]

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Metadata
Title (english)Factors Affecting Outcome in the Treatment of Glioblastoma
Title (croatian)Prediktivni čimbenici u ishodu liječenja glioblastoma
AuthorNenad Koruga https://orcid.org/0000-0001-7555-1155
AuthorTatjana Pekmezović
AuthorIlijan Tomaš
AuthorAnamarija Soldo Koruga
AuthorSilva Butković Soldo
AuthorZvonimir Užarević
AuthorKrešimir Rotim
Author's institution(Sestre milosrdnice University Hospital Center)
Scientific / art field,
discipline and subdiscipline		BIOMEDICINE AND HEALTHCARE
Clinical Medical Sciences
Neurology
Abstract (english)
Treatment of glioblastoma is challenging due to its aggressive and highly invasive nature, and no significant advances in survival have been achieved recently. The aim of our retrospective study was identification of predictive factors and consequent survival outcome in patients who underwent surgical and oncologic treatment of glioblastoma. The study was conducted at the Department of Neurosurgery, Osijek University Hospital Centre. The authors designed a retrospective cohort study in 63 patients who underwent surgical and oncologic treatment between January 1, 2012 and December 31, 2017. Data were collected by reviewing medical records of the patients with histologically proven glioblastoma. Statistical analysis of study results revealed a significant impact of postoperative radiotherapy (p=0.002) and chemotherapy (p=0.016) on progression-free survival and overall survival (p=0.001 and p=0.009, respectively). Postoperative Karnofsky performance scale (p=0.027) was found to be significant in progression-free survival, and so was the interval between surgery and commencement of oncologic therapy (p=0.049). In conclusion, overall survival and prognosis in the treatment of glioblastoma remain poor, although prompt approach in postoperative adjuvant treatments improved progression-free survival.
Abstract (croatian)
Liječenje glioblastoma je izazovno zbog njihove agresivne i vrlo invazivne prirode te u posljednje vrijeme nije postignut značajan napredak u preživljenju. Cilj našega retrospektivnog istraživanja bio je identificirati prediktivne čimbenike i posljedični ishod preživljenja kod bolesnika koji su bili podvrgnuti kirurškom i onkološkom liječenju glioblastoma. Studija je provedena na Klinici za neurokirurgiju Kliničkog bolničkog centra Osijek. Provedena je retrospektivna kohortna studija na 63 bolesnika koji su bili podvrgnuti kirurškom i onkološkom liječenju između 1. siječnja 2012. i 31. prosinca 2017. Podatci su prikupljeni pregledom medicinske dokumentacije bolesnika s histološki dokazanim glioblastomom. Statistička analiza rezultata istraživanja otkrila je značajan utjecaj poslijeoperacijske radioterapije (p=0,002) i kemoterapije (p=0,016) na preživljenje bez progresije bolesti i ukupno preživljenje (p=0,001, p=0,009). Poslijeoperacijska vrijednost na ljestvici Karnofsky (p=0,037) nađena je značajnom za preživljenje bez progresije bolesti, kao i kraći vremenski interval između operacije i početka onkološke terapije (p=0,049). Ukupno preživljenje, kao i prognoza liječenja glioblastoma i dalje su loši, iako pravodobni pristup poslijeoperacijskom adjuvantnom liječenju poboljšava razdoblje preživljenja bez progresije bolesti.
Keywords (english)
Keywords (croatian)
Languageenglish
Languagecroatian
Publication typeScientific paper - Original scientific paper
Publication statusPublished
Peer reviewPeer review - international
Publication versionPublished version
Journal titleActa clinica Croatica
Numberingvol. 60, no. 3, pp. 373-378
p-ISSN0353-9466
e-ISSN1333-9451
DOIhttps://doi.org/10.20471/acc.2021.60.03.06
URN:NBNurn:nbn:hr:220:706285
Publication2021
Document URLhttps://hrcak.srce.hr/271332
Type of resourceText
Access conditionsOpen access
Terms of useLicence Attribution-NonCommercial-NoDerivatives 4.0 International (CC BY-NC-ND 4.0) icon
Created on2024-06-24 07:53:06