prikaz prve stranice dokumenta Anticoagulant selection in relation to the SAMe-TT2R2 score in patients with atrial fibrillation: The GLORIA-AF registry
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Scientific paper - Original scientific paper
Anticoagulant selection in relation to the SAMe-TT2R2 score in patients with atrial fibrillation: The GLORIA-AF registry
Hellenic Journal of Cardiology, 62 (2021), 2; 152-157. https://doi.org/10.1016/j.hjc.2020.11.009
(GLORIA-AF) Ntaios, George; ...; Kes, Vanja Basic; Kalan, Marica Bracic; Brkljacic, Diana Delic; Knezevic, Aleksandar; Kovacic, Dragan; Nazlić, Jurica; Persic, Viktor; Pivac, Nediljko; Poljakovic, Zdravka

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Ntaios, G., Kes, V. B., Kalan, M. B., Brkljacic, D. D., Knezevic, A., Kovacic, D. ... Poljakovic, Z. (2021). Anticoagulant selection in relation to the SAMe-TT2R2 score in patients with atrial fibrillation: The GLORIA-AF registry. Hellenic Journal of Cardiology, 62. (2), 152-157. doi: 10.1016/j.hjc.2020.11.009

Ntaios, George, et al. "Anticoagulant selection in relation to the SAMe-TT2R2 score in patients with atrial fibrillation: The GLORIA-AF registry." Hellenic Journal of Cardiology, vol. 62, no. 2, 2021, pp. 152-157. https://doi.org/10.1016/j.hjc.2020.11.009

Ntaios, George, Vanja Basic Kes, Marica Bracic Kalan, Diana Delic Brkljacic, Aleksandar Knezevic, Dragan Kovacic, Jurica Nazlić, Viktor Persic, Nediljko Pivac and Zdravka Poljakovic. "Anticoagulant selection in relation to the SAMe-TT2R2 score in patients with atrial fibrillation: The GLORIA-AF registry." Hellenic Journal of Cardiology 62, no. 2 (2021): 152-157. https://doi.org/10.1016/j.hjc.2020.11.009

Ntaios, G., et al. (2021) 'Anticoagulant selection in relation to the SAMe-TT2R2 score in patients with atrial fibrillation: The GLORIA-AF registry', Hellenic Journal of Cardiology, 62(2), pp. 152-157. doi: 10.1016/j.hjc.2020.11.009

Ntaios G, Kes VB, Kalan MB, Brkljacic DD, Knezevic A, Kovacic D, and sur.. Anticoagulant selection in relation to the SAMe-TT2R2 score in patients with atrial fibrillation: The GLORIA-AF registry. Hellenic Journal of Cardiology [Internet]. 2021 March [cited 2024 December 08];62(2):152-157. doi: 10.1016/j.hjc.2020.11.009

G. Ntaios, et al., "Anticoagulant selection in relation to the SAMe-TT2R2 score in patients with atrial fibrillation: The GLORIA-AF registry", Hellenic Journal of Cardiology, vol. 62, no. 2, pp. 152-157, March 2021. [Online]. Available at: https://urn.nsk.hr/urn:nbn:hr:220:642947. [Accessed: 08 December 2024]

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Metadata
Title (english)Anticoagulant selection in relation to the SAMe-TT2R2 score in patients with atrial fibrillation: The GLORIA-AF registry
AuthorGeorge Ntaios
Author
...
AuthorVanja Basic Kes
AuthorMarica Bracic Kalan
AuthorDiana Delic Brkljacic
AuthorAleksandar Knezevic
AuthorDragan Kovacic
AuthorJurica Nazlić
AuthorViktor Persic
AuthorNediljko Pivac
AuthorZdravka Poljakovic
CollaborationGLORIA-AF
Author's institution(Sestre milosrdnice University Hospital Center)
Scientific / art field,
discipline and subdiscipline		BIOMEDICINE AND HEALTHCARE
Clinical Medical Sciences
Internal Medicine
Abstract (english)
Aim: The SAMe-TT2R2 score helps identify patients with atrial fibrillation (AF) likely to have poor anti-coagulation control during anticoagulation with vitamin K antagonists (VKA) and those with scores >2 might be better managed with a target-specific oral anticoagulant (NOAC). We hypothesized that in clinical practice, VKAs may be prescribed less frequently to patients with AF and SAMe-TT2R2 scores >2 than to patients with lower scores. Methods and results: We analyzed the Phase III dataset of the Global Registry on Long-Term Oral Antithrombotic Treatment in Patients with Atrial Fibrillation (GLORIA-AF), a large, global, prospective global registry of patients with newly diagnosed AF and 1 stroke risk factor. We compared baseline clinical characteristics and antithrombotic prescriptions to determine the probability of the VKA prescription among anticoagulated patients with the baseline SAMe-TT2R2 score >2 and 2. Among 17,465 anticoagulated patients with AF, 4,828 (27.6%) patients were prescribed VKA and 12,637 (72.4%) patients an NOAC: 11,884 (68.0%) patients had SAMe-TT2R2 scores 0-2 and 5,581 (32.0%) patients had scores >2. The proportion of patients prescribed VKA was 28.0% among patients with SAMe-TT2R2 scores >2 and 27.5% in those with scores 2. Conclusions: The lack of a clear association between the SAMe-TT2R2 score and anticoagulant selection may be attributed to the relative efficacy and safety profiles between NOACs and VKAs as well as to the absence of trial evidence that an SAMe-TT2R2-guided strategy for the selection of the type of anti-coagulation in NVAF patients has an impact on clinical outcomes of efficacy and safety. The latter hypothesis is currently being tested in a randomized controlled trial.
Keywords (english)
Languageenglish
Publication typeScientific paper - Original scientific paper
Publication statusPublished
Peer reviewPeer review
Publication versionPublished version
Journal titleHellenic Journal of Cardiology
Numberingvol. 62, no. 2, pp. 152-157
p-ISSN1109-9666
DOIhttps://doi.org/10.1016/j.hjc.2020.11.009
URN:NBNurn:nbn:hr:220:642947
Publication2021-03
Document URLhttps://linkinghub.elsevier.com/retrieve/pii/S1109966620302815
Type of resourceText
Access conditionsOpen access
Terms of useLicence In copyright icon
Created on2024-06-25 11:34:51