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Scientific paper - Case study
Giant Cavernous Malformation with Unusually Aggressive Clinical Course: a Case Report
Acta clinica Croatica, 59 (2020), 1; 183-187. https://doi.org/10.20471/acc.2020.59.01.24
Grujić, Jovan; Jovanović, Vladimir; Tasić, Goran; Savić, Andrija; Stojiljković, Aleksandra; Matić, Siniša; Lepić, Milan; Rotim, Krešimir; Rasulić, Lukas

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Grujić, J., Jovanović, V., Tasić, G., Savić, A., Stojiljković, A., Matić, S. ... Rasulić, L. (2020). Giant Cavernous Malformation with Unusually Aggressive Clinical Course: a Case Report. Acta clinica Croatica, 59. (1), 183-187. doi: 10.20471/acc.2020.59.01.24

Grujić, Jovan, et al. "Giant Cavernous Malformation with Unusually Aggressive Clinical Course: a Case Report." Acta clinica Croatica, vol. 59, no. 1, 2020, pp. 183-187. https://doi.org/10.20471/acc.2020.59.01.24

Grujić, Jovan, Vladimir Jovanović, Goran Tasić, Andrija Savić, Aleksandra Stojiljković, Siniša Matić, Milan Lepić, Krešimir Rotim and Lukas Rasulić. "Giant Cavernous Malformation with Unusually Aggressive Clinical Course: a Case Report." Acta clinica Croatica 59, no. 1 (2020): 183-187. https://doi.org/10.20471/acc.2020.59.01.24

Grujić, J., et al. (2020) 'Giant Cavernous Malformation with Unusually Aggressive Clinical Course: a Case Report', Acta clinica Croatica, 59(1), pp. 183-187. doi: 10.20471/acc.2020.59.01.24

Grujić J, Jovanović V, Tasić G, Savić A, Stojiljković A, Matić S, and sur.. Giant Cavernous Malformation with Unusually Aggressive Clinical Course: a Case Report. Acta clinica Croatica [Internet]. 2020 [cited 2024 December 08];59(1):183-187. doi: 10.20471/acc.2020.59.01.24

J. Grujić, et al., "Giant Cavernous Malformation with Unusually Aggressive Clinical Course: a Case Report", Acta clinica Croatica, vol. 59, no. 1, pp. 183-187, 2020. [Online]. Available at: https://urn.nsk.hr/urn:nbn:hr:220:073765. [Accessed: 08 December 2024]

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Metadata
Title (english)Giant Cavernous Malformation with Unusually Aggressive Clinical Course: a Case Report
Title (croatian)Divovska kavernozna malformacija s neuobičajeno agresivnim kliničkim tijekom: prikaz slučaja
AuthorJovan Grujić
AuthorVladimir Jovanović
AuthorGoran Tasić
AuthorAndrija Savić
AuthorAleksandra Stojiljković
AuthorSiniša Matić
AuthorMilan Lepić
AuthorKrešimir Rotim
AuthorLukas Rasulić https://orcid.org/0000-0002-5674-0425
Author's institution(Sestre milosrdnice University Hospital Center)
Scientific / art field,
discipline and subdiscipline		BIOMEDICINE AND HEALTHCARE
Clinical Medical Sciences
Neurology
Abstract (english)
Giant cavernomas (GC) are rare lesions, with less than 50 cases reported so far. Clinical presentation usually involves epileptic seizures and less typically focal neurological deficit, due to repeated hemorrhages and GC mass effect and consequentially increased intracranial pressure. Although individual cases have been reported, due to the rarity and variable imaging appearance, GCs are usually not considered in the differential diagnosis of large hemorrhagic lesions, especially when significant mass effect is present. A 17-year-old boy presented due to severe headache, right-sided weakness, and slurred speech. Symptoms started three days before with occasional headaches, which intensified gradually. Emergency computed tomography revealed a left frontal massive heterogeneous lesion. Soon after, right-sided hemiparesis and speech impairment progressed, and the patient became drowsy with the slightly dilated left pupil. Emergency surgery was performed, and the lobed grayish lesion was entirely removed. Based on the macroscopic appearance, the surgeon assumed it was a metastasis of melanoma. Histopathologic analysis result was cavernoma. GC should be considered as an option in hemorrhagic lesions, especially in the young age population. Emergency surgery for mass lesions is not uncommon in neurosurgery; however, bleeding cavernomas are usually planned for elective surgery due to the specific approach and complications.
Abstract (croatian)
Divovski kavernomi (DK) su rijetke lezije s manje od 50 dosad opisanih slučajeva. Uobičajena simptomatologija su epileptični napadaji, a rjeđe se manifestiraju žarišnim neurološkim deficitom koji je uzrokovan ponavljanim hemoragijama i posljedičnim povećanjem intrakranijskog tlaka. Iako su objavljeni pojedini slučajevi, zbog rijetke pojavnosti i raznovrsne radiološke prezentacije DK se obično ne razmatraju u diferencijalnoj dijagnostici velikih hemoragičnih ekspanzivnih lezija, pogotovo kada je prisutan značajan kompresivni učinak. Sedamnaestogodišnji dječak se javio liječniku zbog jake glavobolje, blaže desnostrane slabosti i nerazgovijetnog govora. Simtpomi su se javili 3 dana ranije u vidu blagih glavobolja koje su se postupno pojačavale. Hitna kompjutorizirana tomografija je pokazala masivnu hemoragičnu leziju frontalno lijevo. Nedugo zatim desnostrana slabost i nerazgovijetan govor su se pogoršali i bolesnik je postao pospan s blago proširenom lijevom zjenicom. Učinjena je hitna operacija, kružna sivkasta lezija je u cijelosti uklonjena. Na osnovi makroskopskog izgleda kirurg je pomislio da se radi o metastazi melanoma. Histopatološka analiza je pokazala da se radi o kavernomu. DK bi trebalo razmatrati kao mogućnost kod hemoragičnih lezija, pogotovo kod mlađih bolesnika. Hitna operacija kod kompresivnih lezija nije rijetkost u neurokirurgiji, međutim, krvareći kavernomi se obično planiraju za elektivnu operaciju zbog specifičnog pristupa i mogućih komplikacija.
Keywords (english)
Keywords (croatian)
Languageenglish
Languagecroatian
Publication typeScientific paper - Case study
Publication statusPublished
Peer reviewPeer review - international
Publication versionPublished version
Journal titleActa clinica Croatica
Numberingvol. 59, no. 1, pp. 183-187
p-ISSN0353-9466
e-ISSN1333-9451
DOIhttps://doi.org/10.20471/acc.2020.59.01.24
URN:NBNurn:nbn:hr:220:073765
Publication2020
Document URLhttps://hrcak.srce.hr/242450
Type of resourceText
Access conditionsOpen access
Terms of useLicence Attribution-NonCommercial-NoDerivatives 4.0 International (CC BY-NC-ND 4.0) icon
Created on2024-09-06 09:51:07