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Scientific paper - Original scientific paper
99mTc-MIBI SPECT/CT Scintigraphy and Ultrasound of the Anterior Neck Region in Diagnosing Parathyroid Gland Pathology in Patients with Thyroid Nodules
Acta clinica Croatica, 60 (2021), 3; 423-428. https://doi.org/10.20471/acc.2021.60.03.12
Gladić Nenadić, Vedrana; Šiško Markoš, Ines; Punda, Marija; Blažeković, Ivan; Franceschi, Maja; Fröbe, Ana; Jukić, Tomislav

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Gladić Nenadić, V., Šiško Markoš, I., Punda, M., Blažeković, I., Franceschi, M., Fröbe, A. & Jukić, T. (2021). 99mTc-MIBI SPECT/CT Scintigraphy and Ultrasound of the Anterior Neck Region in Diagnosing Parathyroid Gland Pathology in Patients with Thyroid Nodules. Acta clinica Croatica, 60. (3), 423-428. doi: 10.20471/acc.2021.60.03.12

Gladić Nenadić, Vedrana, et al. "99mTc-MIBI SPECT/CT Scintigraphy and Ultrasound of the Anterior Neck Region in Diagnosing Parathyroid Gland Pathology in Patients with Thyroid Nodules." Acta clinica Croatica, vol. 60, no. 3, 2021, pp. 423-428. https://doi.org/10.20471/acc.2021.60.03.12

Gladić Nenadić, Vedrana, Ines Šiško Markoš, Marija Punda, Ivan Blažeković, Maja Franceschi, Ana Fröbe and Tomislav Jukić. "99mTc-MIBI SPECT/CT Scintigraphy and Ultrasound of the Anterior Neck Region in Diagnosing Parathyroid Gland Pathology in Patients with Thyroid Nodules." Acta clinica Croatica 60, no. 3 (2021): 423-428. https://doi.org/10.20471/acc.2021.60.03.12

Gladić Nenadić, V., et al. (2021) '99mTc-MIBI SPECT/CT Scintigraphy and Ultrasound of the Anterior Neck Region in Diagnosing Parathyroid Gland Pathology in Patients with Thyroid Nodules', Acta clinica Croatica, 60(3), pp. 423-428. doi: 10.20471/acc.2021.60.03.12

Gladić Nenadić V, Šiško Markoš I, Punda M, Blažeković I, Franceschi M, Fröbe A, and sur.. 99mTc-MIBI SPECT/CT Scintigraphy and Ultrasound of the Anterior Neck Region in Diagnosing Parathyroid Gland Pathology in Patients with Thyroid Nodules. Acta clinica Croatica [Internet]. 2021 [cited 2025 March 05];60(3):423-428. doi: 10.20471/acc.2021.60.03.12

V. Gladić Nenadić, et al., "99mTc-MIBI SPECT/CT Scintigraphy and Ultrasound of the Anterior Neck Region in Diagnosing Parathyroid Gland Pathology in Patients with Thyroid Nodules", Acta clinica Croatica, vol. 60, no. 3, pp. 423-428, 2021. [Online]. Available at: https://urn.nsk.hr/urn:nbn:hr:220:715487. [Accessed: 05 March 2025]

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Title (english)99mTc-MIBI SPECT/CT Scintigraphy and Ultrasound of the Anterior Neck Region in Diagnosing Parathyroid Gland Pathology in Patients with Thyroid Nodules
Title (croatian)99mTc-MIBI SPECT/CT scintigrafija i ultrazvuk prednje vratne regije u dijagnostici bolesti paratireoidnih žlijezda kod bolesnika s nodoznim promjenama štitnjače
AuthorVedrana Gladić Nenadić
AuthorInes Šiško Markoš
AuthorMarija Punda
AuthorIvan Blažeković
AuthorMaja Franceschi
AuthorAna Fröbe
AuthorTomislav Jukić
Author's institution(Sestre milosrdnice University Hospital Center)
Scientific / art field,
discipline and subdiscipline		BIOMEDICINE AND HEALTHCARE
Clinical Medical Sciences
Abstract (english)
Parathyroid scintigraphy with 99mTc-MIBI is an imaging technique used in nuclear medicine and performed in patients with suspected hyperparathyroidism (HPT). The objective of this study was to evaluate the role of this technique in patients who, along with suspected HPT, also have thyroid nodules. Retrospective analysis included a period of 8 years (2006-2013). The study included 91 patients with clinical or laboratory suspected HPT. Pathologic changes in parathyroid glands were demonstrated in 47 (70%) of 67 patients with positive scintigraphy. Pathologic changes in parathyroid glands were not evident in the remaining 20 (30%) patients. Out of nine patients with negative scintigraphy results but with suspected enlargement of the parathyroid gland examined by ultrasound, eight (89%) patients did not show pathologic changes in the parathyroid gland, whereas one (11%) patient had evident changes. Eight (54%) of 15 patients with suspected scintigraphy had positive ultrasound findings, as well as fine needle aspiration cytology (FNAC) findings with parathyroid hormone (PTH) determination in the aspirate. Seven (46%) patients had negative FNAC findings and PTH in the aspirate. The study showed scintigraphy to have high sensitivity (98%) in detecting patients with pathologic changes in the parathyroid glands. In patients with suspected HPT, scintigraphy needs to be combined with FNAC and PTH determination in the aspirate due to its low specificity of 28%.
Abstract (croatian)
Scintigrafija paratireoidnih žlijezda 99mTc-MIBI-jem je slikovna metoda nuklearne medicine, a provodi se kod bolesnika sa sumnjom na hiperparatireoidizam (HPT). Cilj istraživanja bio je procijeniti važnost upotrebe ove metode kod bolesnika koji uza sumnju na HPT imaju i nodozne promjene štitnjače. Retrospektivna analiza obuhvatila je razdoblje od 8 godina (2006.-2013.). U studiju je bio uključen 91 bolesnik s klinički ili laboratorijski sumnjivim HPT. Od 67 scintigrafski pozitivnih bolesnika, patološki promijenjena paratireoidna žlijezda dokazana je u njih 47 (70%). U preostalih 20 (30%) bolesnika patološki promijenjena paratireoidna žlijezda nije dokazana. Od 9 bolesnika s negativnim nalazom scintigrafije, a UZV suspektnom povećanom paratireoidnom žlijezdom, patološki promijenjena paratireoidna žlijezda nije dokazana u njih 8 (89%), a dokazana je u jednog (11%) bolesnika. Od 15 scintigrafski dvojbenih bolesnika, njih 8 (54%) je imalo pozitivan nalaz UZV i citološke punkcije uz određivanje PTH u punktatu. U 7 (46%) bolesnika nalaz punkcije i PTH u punktatu bio je negativan. Istraživanje potvrđuje da scintigrafija ima visoku osjetljivost za otkrivanje bolesnika s patološki promijenjenim paratireoidnim žlijezdama (98%). Zbog niske specifičnosti (28%) scintigrafiju treba nadopuniti punkcijom uz određivanje PTH u punktatu u bolesnika sa suspektnim HPT.
Keywords (english)
Keywords (croatian)
Languageenglish
Languagecroatian
Publication typeScientific paper - Original scientific paper
Publication statusPublished
Peer reviewPeer review
Publication versionPublished version
Journal titleActa clinica Croatica
Numberingvol. 60, no. 3, pp. 423-428
p-ISSN0353-9466
e-ISSN1333-9451
DOIhttps://doi.org/10.20471/acc.2021.60.03.12
URN:NBNurn:nbn:hr:220:715487
Publication2021
Document URLhttps://hrcak.srce.hr/271450
Type of resourceText
Access conditionsOpen access
Terms of useLicence In copyright icon
Created on2025-03-05 13:32:24