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Scientific paper - Original scientific paper
Promjene u pojavnosti raka dojke u bolničkom registru (1980-2000)
Liječnički vjesnik, 124 (2002), 11-12; 347-353. urn:nbn:hr:220:023427
Belicza, Mladen; Leniček, Tanja; Glasnović, Margareta; Elez, Martina; Gladić, Vedrana; Marton, Ingrid; Žuteković, Sunčana; Jurlina, Hrvoje; Kusić, Zvonko; Cvrtila, Drago; Strnad, Marija; Tomas, Davor; Čupić, Hrvoje; Krušlin, Božo

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Belicza, M., Leniček, T., Glasnović, M., Elez, M., Gladić, V., Marton, I. ... Krušlin, B. (2002). Promjene u pojavnosti raka dojke u bolničkom registru (1980-2000). Liječnički vjesnik, 124. (11-12), 347-353. Retrieved from https://urn.nsk.hr/urn:nbn:hr:220:023427

Belicza, Mladen, et al. "Promjene u pojavnosti raka dojke u bolničkom registru (1980-2000)." Liječnički vjesnik, vol. 124, no. 11-12, 2002, pp. 347-353. https://urn.nsk.hr/urn:nbn:hr:220:023427

Belicza, Mladen, Tanja Leniček, Margareta Glasnović, Martina Elez, Vedrana Gladić, Ingrid Marton, Sunčana Žuteković, et al. "Promjene u pojavnosti raka dojke u bolničkom registru (1980-2000)." Liječnički vjesnik 124, no. 11-12 (2002): 347-353. https://urn.nsk.hr/urn:nbn:hr:220:023427

Belicza, M., et al. (2002) 'Promjene u pojavnosti raka dojke u bolničkom registru (1980-2000)', Liječnički vjesnik, 124(11-12), pp. 347-353. Available at: https://urn.nsk.hr/urn:nbn:hr:220:023427 (Accessed 01 April 2025)

Belicza M, Leniček T, Glasnović M, Elez M, Gladić V, Marton I, and sur.. Promjene u pojavnosti raka dojke u bolničkom registru (1980-2000). Liječnički vjesnik [Internet]. 2002 [cited 2025 April 01];124(11-12):347-353. Available at: https://urn.nsk.hr/urn:nbn:hr:220:023427

M. Belicza, et al., "Promjene u pojavnosti raka dojke u bolničkom registru (1980-2000)", Liječnički vjesnik, vol. 124, no. 11-12, pp. 347-353, 2002. [Online]. Available at: https://urn.nsk.hr/urn:nbn:hr:220:023427. [Accessed: 01 April 2025]

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Metadata
Title (croatian)Promjene u pojavnosti raka dojke u bolničkom registru (1980-2000)
Title (english)Changes in occurrence of breast cancer in the hospital's registry (1980-2000)
AuthorMladen Belicza
AuthorTanja Leniček
AuthorMargareta Glasnović
AuthorMartina Elez
AuthorVedrana Gladić
AuthorIngrid Marton
AuthorSunčana Žuteković
AuthorHrvoje Jurlina
AuthorZvonko Kusić
AuthorDrago Cvrtila
AuthorMarija Strnad
AuthorDavor Tomas
AuthorHrvoje Čupić
AuthorBožo Krušlin
Author's institution(Sestre milosrdnice University Hospital Center)
Scientific / art field,
discipline and subdiscipline		BIOMEDICINE AND HEALTHCARE
Clinical Medical Sciences
Abstract (croatian)
Cilj je istraživanja analizirati distribuciju histoloških tipova, dobi i hormonske ovisnosti karcinoma dojke na temelju podataka kompjutorskog sustava »Thanatos« tijekom razdoblja od 1980. do 2000. godine. Istraživano razdoblje smo podijelili u odnosu na ratna događanja (razdoblje prije rata: 1980 - 1990, za vrijeme rata: 1991— 1995. i poslije rata: 1996-2000) i černobilski incident (razdoblje prije: 1980-1986. i poslije: 1987-2000). Interes nam je posebno privuklo ratno razdoblje s obzirom na... More to da o ratnom stresu, kao induktoru i promotoru karcinogeneze, ima malo dostupne literature. Tijekom razdoblja 1980 - 2000. dijagnosticirano je 2296 bolesnika s karcinomom dojke. Od toga je u žena bilo 2228 (98%) duktalnih i 46 (2%) lobularnih invazivnih karcinoma dojke. U svim slučajevima raka dojke u muškaraca (22 bolesnika) patohistološki se radilo o duktalnom invazivnom karcinomu, a M:Ž omjer bio je 1:103. Uspoređujući razdoblje prije i za vrijeme rata, nalazimo više nego dvostruki porast M/Ž omjera s 1:131 na 1:66. Sličan rezultat dobili smo i u razdoblju nakon černobilskog incidenta kada omjer s 1:139 raste na 1:79. Analizom distribucije histoloških tipova vidimo signifikantan porast pojavnosti lobularnog karcinoma u poslijeratnom razdoblju s 1,1% na 5.5% te uočljiv, ali manje izražen, porast u postčernobilskom razdoblju (s 1,0% na 3,3%). Prosječna dob bolesnica s duktalnim invazivnim karcinomom raste s 56,7 godina u periodu prije rata preko 59,7 u ratu na 61,1 godinu u razdoblju nakon rata. Nasuprot tomu prosječna dob u vrijeme postavljanja dijagnoze, kod muških bolesnika s bolesti otkrivenom u periodu nakon rata, niža je za gotovo 5 godina (58.8 godina) od dobi izračunane za ostala dva razdoblja (63,6 ili 63,5 godina). Uspoređujući stadije bolesti prema pTNM klasifikaciji u ratnom i poslijeratnom periodu, najčešće dijagnosticiran stadij u vrijeme postavljanja dijagnoze duktalnog invazivnog karcinoma dojke bio je T1N0MX, a u kontrolnom periodu (1989-1990) T2N1MX. Time vidimo da naglašeni porast dobi bolesnica nije praćen nalazom kasnijeg pTNM stadija, što ne ide u prilog teoriji o porastu dobi naših bolesnica uzrokovanom kasnijim javljanjem liječniku zbog ratnih previranja. Naši rezultati pokazuju da je većina bolesnica imala pozitivne ER (72%), a pozitivnost i visina koncentracije raste s dobi pacijentica. Utvrdili smo signifikantni pad hormonski visoko ovisnih tumora u periodu od 1991. do 1995, što bi moglo značiti da su bolesnice u ratu manifestirale agresivniji fenotip tumora. Naša studija pokazuje da su ratna događanja na našim prostorima vjerojatno utjecala na promjene nekih kliničkih parametara kod bolesnika s rakom dojke. Mogući utjecaj černobilskog incidenta nije se mogao dokazati, a efekti u postčernobilskom razdoblju vjerojatno su posljedica promjena vezanih uz ratni stres. Less
Abstract (english)
The aim of our retrospective study was to analyze distribution of histological types, age of patients and hormonal dependency of breast cancer cases in the period 1980-2000 using computer database » Thanatos«. This period was divided with regard to the war into a pre-war (1980—1990), war (1991—1995) and post-war period (1996-2000). We also paid attention to the Chernobyl accident (pre-Chernobyl from 1980-1986 and post-Chernobyl from 1987-2000). Special attention was focused on the period... More during the war mainly due to the fact that very little data exist in literature dealing with the war as a stress factor that may have induced and promoted carcinogenesis. During this twenty-one year period 2296 patients were diagnosed with breast cancer. In the female population of 2274, 2228 (98%) of these were ductal and only 46 (2%) were invasive lobular carcinomas. In all of the male cases (22) the cancer was pathohistologically verified as the invasive ductal type. The male:female ratio was 1:103. Comparing the pre-war and war periods we found a more than double increase in the male:female ratio (from 1:131 to 1:66). We observed similar results when we looked at the period after the Chernobyl incident where the ratio increased from 1:139 to 1:79. When we analyzed the distribution of histological types we found a significant increase in lobular carcinomas during the post-war period, from 1.1% to 5.5%; this increase was less significant for the post-Chernobyl period (1.0% to 3.3%). The average age of the patients with invasive ductal carcinomas increased from 56.7 yrs during the pre-war period to 59.7 yrs during the war and finally to 61.1 yrs during the post-war period. The average age of males with breast cancer decreased from 63.6 and 63.5 during the pre-war and war periods to 58.8 yrs during the post-war period. These results suggest that the war could have influenced the shift in the age of occurrence of breast cancer in both sexes appearing in younger males and in females in their postmenopausal period. The most commonly diagnosed stage of invasive ductal carcinoma during thw war and post-war periods was T1N0MX, but in the controlled pre-war period the most frequently diagnosed stage was T2N1MX. With this we see that the increase in the age of the patient is not due to a more advanced pTNM stage which suggests that the increased age of our patients seeking medical help is not due to the incapacitating effects that the war may have on people needing medical attention. Our results showed that most of the patients were ER positive (72% throughout the twenty-one year period) and their average rate and number increase with the age of the patient. We found a significant drop in hormone dependent tumors in the period from 1991-95, which could mean that tumors in a war environment manifest a more aggressive phenotype. Our results show that the war within our region most likely had an effect on some clinical parameters involving breast ca patients. Possible effects caused by »Chernobyl« could not be proved due to the overwhelming effect that war had upon the patients within this region. Less
Keywords (croatian)
Keywords (english)
Languagecroatian
Publication typeScientific paper - Original scientific paper
Publication statusPublished
Peer reviewPeer review
Publication versionPublished version
Journal titleLiječnički vjesnik
Numberingvol. 124, no. 11-12, pp. 347-353
p-ISSN0024-3477
e-ISSN1849-2177
URN:NBNurn:nbn:hr:220:023427
Publication2002
Type of resourceText
Access conditionsOpen access
Terms of useLicence In copyright icon
Created on2025-03-17 12:49:44
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