prikaz prve stranice dokumenta Connection between Inflammatory Markers, Antidepressants and Depression
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Scientific paper - Original scientific paper
Connection between Inflammatory Markers, Antidepressants and Depression
Acta clinica Croatica, 51 (2012), 1; 25-33. urn:nbn:hr:220:841742
Crnković, Danijel; Buljan, Danijel; Karlović, Dalibor; Krmek, Marija

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Crnković, D., Buljan, D., Karlović, D. & Krmek, M. (2012). Connection between Inflammatory Markers, Antidepressants and Depression. Acta clinica Croatica, 51. (1), 25-33. Retrieved from https://urn.nsk.hr/urn:nbn:hr:220:841742

Crnković, Danijel, et al. "Connection between Inflammatory Markers, Antidepressants and Depression." Acta clinica Croatica, vol. 51, no. 1, 2012, pp. 25-33. https://urn.nsk.hr/urn:nbn:hr:220:841742

Crnković, Danijel, Danijel Buljan, Dalibor Karlović and Marija Krmek. "Connection between Inflammatory Markers, Antidepressants and Depression." Acta clinica Croatica 51, no. 1 (2012): 25-33. https://urn.nsk.hr/urn:nbn:hr:220:841742

Crnković, D., et al. (2012) 'Connection between Inflammatory Markers, Antidepressants and Depression', Acta clinica Croatica, 51(1), pp. 25-33. Available at: https://urn.nsk.hr/urn:nbn:hr:220:841742 (Accessed 18 November 2024)

Crnković D, Buljan D, Karlović D, Krmek M. Connection between Inflammatory Markers, Antidepressants and Depression. Acta clinica Croatica [Internet]. 2012 [cited 2024 November 18];51(1):25-33. Available at: https://urn.nsk.hr/urn:nbn:hr:220:841742

D. Crnković, D. Buljan, D. Karlović and M. Krmek, "Connection between Inflammatory Markers, Antidepressants and Depression", Acta clinica Croatica, vol. 51, no. 1, pp. 25-33, 2012. [Online]. Available at: https://urn.nsk.hr/urn:nbn:hr:220:841742. [Accessed: 18 November 2024]

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Metadata
Title (english)Connection between Inflammatory Markers, Antidepressants and Depression
Title (croatian)Povezanost upalnih biljega, antidepresiva i depresije
AuthorDanijel Crnković
AuthorDanijel Buljan
AuthorDalibor Karlović
AuthorMarija Krmek
Author's institution(Sestre milosrdnice University Hospital Center)
Scientific / art field,
discipline and subdiscipline		BIOMEDICINE AND HEALTHCARE
Clinical Medical Sciences
Psychiatry
Abstract (english)
The aim of this study was to explore the role of inflammatory markers in the occurrence of depression. The concentrations of inflammatory markers were analyzed in the groups of healthy subjects and subjects with major depressive disorder (MDD ) initially and after one-month antidepressant therapy in the latter. The intention was to demonstrate the role of inflammatory markers in the development of MDD by differences in their concentrations and to explain the mechanism of depression development. This would help us expand our understanding of the occurrence of depression and enable introduction of some new methods in the treatment and diagnosis of depression. Study results showed a statistically significant difference in the concentrations of inflammatory markers (C-reactive protein (CRP), interleukin-6 and tumor necrosis factor alpha) between the group of MDD subjects and control group of healthy subjects. These concentrations were higher in MDD subjects. A statistically significant difference was also found in CRP concentration before and after antidepressant therapy administered to MDD patients, i.e. it was lower after antidepressant therapy. Study results pointed to the efficacy of antidepressant therapy for depression by reducing the concentration of this inflammatory marker.
Abstract (croatian)
Cilj ovoga istraživanja bio je ispitati ulogu upalnih faktora u mehanizmu nastanka depresije. Analizirane su koncentracije upalnih čimbenika između skupina zdravih ispitanika i ispitanika oboljelih od depresije pri dolasku i mjesec dana od početka liječenja antidepresivima u potonjoj skupini. Temeljem razlika u koncentracijama navedenih čimbenika željelo se potvrditi njihovu ulogu u nastanku depresije i objasniti mehanizam nastanka depresije. Time bi se uz proširivanje spoznaje o uzroku nastanka depresije mogle primijeniti i nove metode liječenja i dijagnostike depresije. Ovim radom pokazano je postojanje statistički značajne razlike u koncentracijama upalnih faktora (CRP, IL -6 i TNF -α) između zdravih ispitanika i onih oboljelih od depresije. Navedene koncentracije su bile više kod depresivnih ispitanika. Nadalje, nakon terapije antidepresivima zabilježena je statistički značajna razlika u koncentraciji CRP u odnosu na početak liječenja, tj. CRP je bio niži nakon terapije antidepresivima. Dobiveni rezultati govore u prilog učinkovitosti terapijskog djelovanja antidepresiva u liječenju depresije kroz snižavanje koncentracije ovoga upalnog čimbenika.
Keywords (english)
Keywords (croatian)
Languageenglish
Languagecroatian
Publication typeScientific paper - Original scientific paper
Publication statusPublished
Peer reviewPeer review - international
Publication versionPublished version
Journal titleActa clinica Croatica
Numberingvol. 51, no. 1, pp. 25-33
p-ISSN0353-9466
e-ISSN1333-9451
URN:NBNurn:nbn:hr:220:841742
Publication2012
Document URLhttps://hrcak.srce.hr/85732
Type of resourceText
Access conditionsOpen access
Terms of useLicence Attribution-NonCommercial-NoDerivatives 4.0 International (CC BY-NC-ND 4.0) icon
Created on2023-09-28 10:23:48