prikaz prve stranice dokumenta In situ gelling nanosuspension as an advanced platform for fluticasone propionate nasal delivery
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Scientific paper - Original scientific paper
In situ gelling nanosuspension as an advanced platform for fluticasone propionate nasal delivery
European Journal of Pharmaceutics and Biopharmaceutics, 175 (2022); 27-42. https://doi.org/10.1016/j.ejpb.2022.04.009
Nižić Nodilo, Laura; Perkušić, Mirna; Ugrina, Ivo; Špoljarić, Drago; Jakobušić Brala, Cvijeta; Amidžić Klarić, Daniela; Lovrić, Jasmina; Saršon, Vesna; Safundžić Kučuk, Maša; Zadravec, Dijana; Kalogjera, Livije; Pepić, Ivan; Hafner, Anita

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Nižić Nodilo, L., Perkušić, M., Ugrina, I., Špoljarić, D., Jakobušić Brala, C., Amidžić Klarić, D. ... Hafner, A. (2022). In situ gelling nanosuspension as an advanced platform for fluticasone propionate nasal delivery. European Journal of Pharmaceutics and Biopharmaceutics, 175., 27-42. doi: 10.1016/j.ejpb.2022.04.009

Nižić Nodilo, Laura, et al. "In situ gelling nanosuspension as an advanced platform for fluticasone propionate nasal delivery." European Journal of Pharmaceutics and Biopharmaceutics, vol. 175, 2022, pp. 27-42. https://doi.org/10.1016/j.ejpb.2022.04.009

Nižić Nodilo, Laura, Mirna Perkušić, Ivo Ugrina, Drago Špoljarić, Cvijeta Jakobušić Brala, Daniela Amidžić Klarić, Jasmina Lovrić, et al. "In situ gelling nanosuspension as an advanced platform for fluticasone propionate nasal delivery." European Journal of Pharmaceutics and Biopharmaceutics 175 (2022): 27-42. https://doi.org/10.1016/j.ejpb.2022.04.009

Nižić Nodilo, L., et al. (2022) 'In situ gelling nanosuspension as an advanced platform for fluticasone propionate nasal delivery', European Journal of Pharmaceutics and Biopharmaceutics, 175, pp. 27-42. doi: 10.1016/j.ejpb.2022.04.009

Nižić Nodilo L, Perkušić M, Ugrina I, Špoljarić D, Jakobušić Brala C, Amidžić Klarić D, and sur.. In situ gelling nanosuspension as an advanced platform for fluticasone propionate nasal delivery. European Journal of Pharmaceutics and Biopharmaceutics [Internet]. 2022 [cited 2024 December 09];175:27-42. doi: 10.1016/j.ejpb.2022.04.009

L. Nižić Nodilo, et al., "In situ gelling nanosuspension as an advanced platform for fluticasone propionate nasal delivery", European Journal of Pharmaceutics and Biopharmaceutics, vol. 175, pp. 27-42, 2022. [Online]. Available at: https://urn.nsk.hr/urn:nbn:hr:220:438756. [Accessed: 09 December 2024]

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Metadata
Title (english)In situ gelling nanosuspension as an advanced platform for fluticasone propionate nasal delivery
AuthorLaura Nižić Nodilo
AuthorMirna Perkušić
AuthorIvo Ugrina
AuthorDrago Špoljarić
AuthorCvijeta Jakobušić Brala
AuthorDaniela Amidžić Klarić
AuthorJasmina Lovrić
AuthorVesna Saršon
AuthorMaša Safundžić Kučuk
AuthorDijana Zadravec
AuthorLivije Kalogjera
AuthorIvan Pepić
AuthorAnita Hafner
Author's institution(Sestre milosrdnice University Hospital Center)
Scientific / art field,
discipline and subdiscipline		BIOMEDICINE AND HEALTHCARE
Clinical Medical Sciences
Otorhinolaryngology
Abstract (english)
In this work we present the development of in situ gelling nanosuspension as advanced form for fluticasone propionate nasal delivery. Drug nanocrystals were prepared by wet milling technique. Incorporation of drug nanocrystals into polymeric in situ gelling system with pectin and sodium hyaluronate as constitutive polymers was fine-tuned attaining appropriate formulation surface tension, viscosity and gelling ability. Drug nanonisation improved the release profile and enhanced formulation mucoadhesive properties. QbD approach combining formulation and administration parameters resulted in optimised nasal deposition profile, with 51.8% of the dose deposited in the middle meatus, the critical region in the treatment of rhinosinusitis and nasal polyposis. Results obtained in biocompatibility and physico-chemical stability studies confirmed the leading formulation potential for safe and efficient nasal corticosteroid delivery.
Keywords (english)
Languageenglish
Publication typeScientific paper - Original scientific paper
Publication statusPublished
Peer reviewPeer review
Publication versionPublished version
Journal titleEuropean Journal of Pharmaceutics and Biopharmaceutics
Numberingvol. 175, pp. 27-42
p-ISSN0939-6411
DOIhttps://doi.org/10.1016/j.ejpb.2022.04.009
URN:NBNurn:nbn:hr:220:438756
Publication2022
Document URLhttps://www.sciencedirect.com/science/article/abs/pii/S0939641122000819?via%3Dihub
Type of resourceText
Access conditionsInstitutional access
Terms of useLicence In copyright icon
Created on2023-12-15 10:51:47