prikaz prve stranice dokumenta Proofs for implementation of higher HE4 and ROMA index cut-off values in ovarian cancer preoperative stratification
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Scientific paper - Original scientific paper
Proofs for implementation of higher HE4 and ROMA index cut-off values in ovarian cancer preoperative stratification
Journal of Obstetrics and Gynaecology, 39 (2019), 2; 195-201. https://doi.org/10.1080/01443615.2018.1476471
Špacir Prskalo, Zvjezdana; Bulić, Petra; Langer, Sanja; Gaće, Mihaela; Puljiz, Mario; Danolić, Damir; Alvir, Ilija; Mamić, Ivica; Šušnjar, Lucija; Mayer, Ljiljana

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Špacir Prskalo, Z., Bulić, P., Langer, S., Gaće, M., Puljiz, M., Danolić, D. ... Mayer, Lj. (2019). Proofs for implementation of higher HE4 and ROMA index cut-off values in ovarian cancer preoperative stratification. Journal of Obstetrics and Gynaecology, 39. (2), 195-201. doi: 10.1080/01443615.2018.1476471

Špacir Prskalo, Zvjezdana, et al. "Proofs for implementation of higher HE4 and ROMA index cut-off values in ovarian cancer preoperative stratification." Journal of Obstetrics and Gynaecology, vol. 39, no. 2, 2019, pp. 195-201. https://doi.org/10.1080/01443615.2018.1476471

Špacir Prskalo, Zvjezdana, Petra Bulić, Sanja Langer, Mihaela Gaće, Mario Puljiz, Damir Danolić, Ilija Alvir, Ivica Mamić, Lucija Šušnjar and Ljiljana Mayer. "Proofs for implementation of higher HE4 and ROMA index cut-off values in ovarian cancer preoperative stratification." Journal of Obstetrics and Gynaecology 39, no. 2 (2019): 195-201. https://doi.org/10.1080/01443615.2018.1476471

Špacir Prskalo, Z., et al. (2019) 'Proofs for implementation of higher HE4 and ROMA index cut-off values in ovarian cancer preoperative stratification', Journal of Obstetrics and Gynaecology, 39(2), pp. 195-201. doi: 10.1080/01443615.2018.1476471

Špacir Prskalo Z, Bulić P, Langer S, Gaće M, Puljiz M, Danolić D, and sur.. Proofs for implementation of higher HE4 and ROMA index cut-off values in ovarian cancer preoperative stratification. Journal of Obstetrics and Gynaecology [Internet]. 2019 [cited 2025 January 22];39(2):195-201. doi: 10.1080/01443615.2018.1476471

Z. Špacir Prskalo, et al., "Proofs for implementation of higher HE4 and ROMA index cut-off values in ovarian cancer preoperative stratification", Journal of Obstetrics and Gynaecology, vol. 39, no. 2, pp. 195-201, 2019. [Online]. Available at: https://urn.nsk.hr/urn:nbn:hr:220:355695. [Accessed: 22 January 2025]

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Metadata
Title (english)Proofs for implementation of higher HE4 and ROMA index cut-off values in ovarian cancer preoperative stratification
AuthorZvjezdana Špacir Prskalo
AuthorPetra Bulić
AuthorSanja Langer
AuthorMihaela Gaće
AuthorMario Puljiz
AuthorDamir Danolić
AuthorIlija Alvir
AuthorIvica Mamić
AuthorLucija Šušnjar
AuthorLjiljana Mayer
Author's institution(Sestre milosrdnice University Hospital Center)
Scientific / art field,
discipline and subdiscipline		BIOMEDICINE AND HEALTHCARE
Clinical Medical Sciences
Gynecology and Obstetrics
Abstract (english)
This study aimed to identify and quantify the clinical significance of the HE4 and ROMA index in patients with an adnexal tumour. We recruited 159 women and the HE4 and CA125 were measured with an electrochemiluminescence immunoassay in the sera. We used the Kolmogorov–Smirnov test, Mann–Whitney’s test and logistic regression to interpret the data. In the premenopausal group (n = 57), the ROC analysis (with cut-off: 86.1 pmol/L for HE4; 40.7 U/L for CA125 and 21.9% for ROMA) demonstrated the superior prognostic potential of those markers when the higher cut-offs used are compared to producers. The AUC for HE4/CA125/ROMA were 0.846/0.867/0.846, respectively. The HE4/ROMA showed 85.7% sensitivity and 94% specificity. In the postmenopausal group (n = 102), the ROC analysis cut-off values were: 99.8 pmol/L for HE4; 45.8 U/L for CA125 and 38.4% for ROMA. AUC for HE4/CA125/ROMA were 0.928/0.899/0.927, respectively. HE4 had an 86.1% sensitivity at 92.4% specificity, while ROMA showed an 88.9% sensitivity at a 90.9% specificity.
Keywords (english)
Languageenglish
Publication typeScientific paper - Original scientific paper
Publication statusPublished
Peer reviewUnknown
Publication versionPublished version
Journal titleJournal of Obstetrics and Gynaecology
Numberingvol. 39, no. 2, pp. 195-201
p-ISSN0144-3615
e-ISSN1364-6893
DOIhttps://doi.org/10.1080/01443615.2018.1476471
URN:NBNurn:nbn:hr:220:355695
Publication2019
Document URLhttps://www.tandfonline.com/doi/full/10.1080/01443615.2018.1476471
Type of resourceText
Access conditionsInstitutional access
Terms of useLicence In copyright icon
Created on2024-06-10 10:06:06