prikaz prve stranice dokumenta Patterns of oral anticoagulant use and outcomes in Asian patients with atrial fibrillation: a post-hoc analysis from the GLORIA-AF Registry
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Scientific paper - Original scientific paper
Patterns of oral anticoagulant use and outcomes in Asian patients with atrial fibrillation: a post-hoc analysis from the GLORIA-AF Registry
eClinicalMedicine, 63 (2023); 102039. https://doi.org/10.1016/j.eclinm.2023.102039
(GLORIA-AF) Romiti, Giulio Francesco; ...; Kes, Vanja Basic; Kalan, Marica Bracic; Brkljacic, Diana Delic; Knezevic, Aleksandar; Kovacic, Dragan; Nazlić, Jurica; Persic, Viktor; Pivac, Nediljko; Poljakovic, Zdravka

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Romiti, G. F., Kes, V. B., Kalan, M. B., Brkljacic, D. D., Knezevic, A., Kovacic, D. ... Poljakovic, Z. (2023). Patterns of oral anticoagulant use and outcomes in Asian patients with atrial fibrillation: a post-hoc analysis from the GLORIA-AF Registry. eClinicalMedicine, 63.. doi: 10.1016/j.eclinm.2023.102039

Romiti, Giulio Francesco, et al. "Patterns of oral anticoagulant use and outcomes in Asian patients with atrial fibrillation: a post-hoc analysis from the GLORIA-AF Registry." eClinicalMedicine, vol. 63, 2023. https://doi.org/10.1016/j.eclinm.2023.102039

Romiti, Giulio Francesco, Vanja Basic Kes, Marica Bracic Kalan, Diana Delic Brkljacic, Aleksandar Knezevic, Dragan Kovacic, Jurica Nazlić, Viktor Persic, Nediljko Pivac and Zdravka Poljakovic. "Patterns of oral anticoagulant use and outcomes in Asian patients with atrial fibrillation: a post-hoc analysis from the GLORIA-AF Registry." eClinicalMedicine 63 (2023). https://doi.org/10.1016/j.eclinm.2023.102039

Romiti, G. F., et al. (2023) 'Patterns of oral anticoagulant use and outcomes in Asian patients with atrial fibrillation: a post-hoc analysis from the GLORIA-AF Registry', eClinicalMedicine, 63. doi: 10.1016/j.eclinm.2023.102039

Romiti GF, Kes VB, Kalan MB, Brkljacic DD, Knezevic A, Kovacic D, and sur.. Patterns of oral anticoagulant use and outcomes in Asian patients with atrial fibrillation: a post-hoc analysis from the GLORIA-AF Registry. eClinicalMedicine [Internet]. 2023 September [cited 2025 April 01];63. doi: 10.1016/j.eclinm.2023.102039

G. F. Romiti, et al., "Patterns of oral anticoagulant use and outcomes in Asian patients with atrial fibrillation: a post-hoc analysis from the GLORIA-AF Registry", eClinicalMedicine, vol. 63, September 2023. [Online]. Available at: https://urn.nsk.hr/urn:nbn:hr:220:708360. [Accessed: 01 April 2025]

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Title (english)Patterns of oral anticoagulant use and outcomes in Asian patients with atrial fibrillation: a post-hoc analysis from the GLORIA-AF Registry
AuthorGiulio Francesco Romiti
Author
...
AuthorVanja Basic Kes
AuthorMarica Bracic Kalan
AuthorDiana Delic Brkljacic
AuthorAleksandar Knezevic
AuthorDragan Kovacic
AuthorJurica Nazlić
AuthorViktor Persic
AuthorNediljko Pivac
AuthorZdravka Poljakovic
CollaborationGLORIA-AF
Author's institution(Sestre milosrdnice University Hospital Center)
Scientific / art field,
discipline and subdiscipline		BIOMEDICINE AND HEALTHCARE
Clinical Medical Sciences
Internal Medicine
Abstract (english)
Background: Previous studies suggested potential ethnic differences in the management and outcomes of atrial fibrillation (AF). We aim to analyse oral anticoagulant (OAC) prescription, discontinuation, and risk of adverse outcomes in Asian patients with AF, using data from a global prospective cohort study. Methods: From the GLORIA-AF Registry Phase II–III (November 2011–December 2014 for Phase II, and January 2014–December 2016 for Phase III), we analysed patients according to their... More self-reported ethnicity (Asian vs. non-Asian), as well as according to Asian subgroups (Chinese, Japanese, Korean and other Asian). Logistic regression was used to analyse OAC prescription, while the risk of OAC discontinuation and adverse outcomes were analysed through Cox-regression model. Our primary outcome was the composite of all-cause death and major adverse cardiovascular events (MACE). The original studies were registered with ClinicalTrials.gov, NCT01468701, NCT01671007, and NCT01937377. Findings: 34,421 patients were included (70.0 ± 10.5 years, 45.1% females, 6900 (20.0%) Asian: 3829 (55.5%) Chinese, 814 (11.8%) Japanese, 1964 (28.5%) Korean and 293 (4.2%) other Asian). Most of the Asian patients were recruited in Asia (n = 6701, 97.1%), while non-Asian patients were mainly recruited in Europe (n = 15,449, 56.1%) and North America (n = 8378, 30.4%). Compared to non-Asian individuals, prescription of OAC and non-vitamin K antagonist oral anticoagulant (NOAC) was lower in Asian patients (Odds Ratio [OR] and 95% Confidence Intervals (CI): 0.23 [0.22–0.25] and 0.66 [0.61–0.71], respectively), but higher in the Japanese subgroup. Asian ethnicity was also associated with higher risk of OAC discontinuation (Hazard Ratio [HR] and [95% CI]: 1.79 [1.67–1.92]), and lower risk of the primary composite outcome (HR [95% CI]: 0.86 [0.76–0.96]). Among the exploratory secondary outcomes, Asian ethnicity was associated with higher risks of thromboembolism and intracranial haemorrhage, and lower risk of major bleeding. Interpretation: Our results showed that Asian patients with AF showed suboptimal thromboembolic risk management and a specific risk profile of adverse outcomes; these differences may also reflect differences in country-specific factors. Ensuring integrated and appropriate treatment of these patients is crucial to improve their prognosis. Less
Keywords (english)
Languageenglish
Publication typeScientific paper - Original scientific paper
Publication statusPublished
Peer reviewPeer review
Publication versionPublished version
Journal titleeClinicalMedicine
Numberingvol. 63, 102039
p-ISSN2589-5370
DOIhttps://doi.org/10.1016/j.eclinm.2023.102039
URN:NBNurn:nbn:hr:220:708360
Publication2023-09
Document URLhttps://linkinghub.elsevier.com/retrieve/pii/S258953702300216X
Type of resourceText
Access conditionsOpen access
Terms of useLicence In copyright icon
Created on2024-06-17 12:38:52
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