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Scientific paper - Original scientific paper
Impact of Neurotropic Viruses on Survival of Patients with Surgically Treated Glioblastoma
Acta clinica Croatica, 61 (2022), 3; 476-481. https://doi.org/10.20471/acc.2022.61.03.12
Koruga, Nenad; Pekmezović, Tatjana; Tomaš, Ilijan; Soldo Koruga, Anamarija; Marjanović, Ksenija; Rajc, Jasmina; Rotim, Ante; Rotim, Krešimir

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Koruga, N., Pekmezović, T., Tomaš, I., Soldo Koruga, A., Marjanović, K., Rajc, J. ... Rotim, K. (2022). Impact of Neurotropic Viruses on Survival of Patients with Surgically Treated Glioblastoma. Acta clinica Croatica, 61. (3), 476-481. doi: 10.20471/acc.2022.61.03.12

Koruga, Nenad, et al. "Impact of Neurotropic Viruses on Survival of Patients with Surgically Treated Glioblastoma." Acta clinica Croatica, vol. 61, no. 3, 2022, pp. 476-481. https://doi.org/10.20471/acc.2022.61.03.12

Koruga, Nenad, Tatjana Pekmezović, Ilijan Tomaš, Anamarija Soldo Koruga, Ksenija Marjanović, Jasmina Rajc, Ante Rotim and Krešimir Rotim. "Impact of Neurotropic Viruses on Survival of Patients with Surgically Treated Glioblastoma." Acta clinica Croatica 61, no. 3 (2022): 476-481. https://doi.org/10.20471/acc.2022.61.03.12

Koruga, N., et al. (2022) 'Impact of Neurotropic Viruses on Survival of Patients with Surgically Treated Glioblastoma', Acta clinica Croatica, 61(3), pp. 476-481. doi: 10.20471/acc.2022.61.03.12

Koruga N, Pekmezović T, Tomaš I, Soldo Koruga A, Marjanović K, Rajc J, and sur.. Impact of Neurotropic Viruses on Survival of Patients with Surgically Treated Glioblastoma. Acta clinica Croatica [Internet]. 2022 [cited 2024 December 07];61(3):476-481. doi: 10.20471/acc.2022.61.03.12

N. Koruga, et al., "Impact of Neurotropic Viruses on Survival of Patients with Surgically Treated Glioblastoma", Acta clinica Croatica, vol. 61, no. 3, pp. 476-481, 2022. [Online]. Available at: https://urn.nsk.hr/urn:nbn:hr:220:026625. [Accessed: 07 December 2024]

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Metadata
Title (english)Impact of Neurotropic Viruses on Survival of Patients with Surgically Treated Glioblastoma
Title (croatian)Utjecaj neurotropnih virusa na preživljenje pacijenata operiranih od glioblastoma
AuthorNenad Koruga https://orcid.org/0000-0001-7555-1155
AuthorTatjana Pekmezović https://orcid.org/0000-0001-7978-1409
AuthorIlijan Tomaš
AuthorAnamarija Soldo Koruga
AuthorKsenija Marjanović
AuthorJasmina Rajc https://orcid.org/0000-0003-4007-8390
AuthorAnte Rotim
AuthorKrešimir Rotim
Author's institution(Sestre milosrdnice University Hospital Center)
Scientific / art field,
discipline and subdiscipline		BIOMEDICINE AND HEALTHCARE
Clinical Medical Sciences
Neurology
Abstract (english)
Introduction: Glioblastoma represents the most aggressive tumor of the brain with an estimated survival rate of twelve to fifteen months after the primary diagnosis. The role of neurotropic viruses in pathogenesis of the tumor has remained unclear to date. During the last two decades, many studies were conducted with the aim of confirming viral influence in the development of glioblastoma. Methods: We conducted a retrospective study in a time period of five years using formalin-fixed paraffin-embedded tissues of glioblastoma. Immunohistochemistry was performed for three viruses: CMV, EBV and HSV-1, using an automated staining system. Results: Mean age of patients in our group was 66.7±8.5 years. A slight male dominance was noted. Negative immunohistochemistry results were obtained for CMV and EBV, which were excluded from further investigation. Based on IRS score, we confirmed six HSV-1 samples which were rated as IRS score 2. Five more samples of HSV-1 were rated as IRS score 1 and were excluded from the study. Conclusion: According to our retrospective study and its results, we found no impact of neurotropic viruses in the survival rate of glioblastoma. Further studies should be conducted including a wider range of viral detection methods.
Abstract (croatian)
Uvod: Glioblastom predstavlja najagresivniji tumor mozga s procijenjenom stopom preživljenja od dvanaest do petnaest mjeseci nakon primarne dijagnoze. Uloga neurotropnih virusa u patogenezi tumora do danas je nejasna. Tijekom posljednja dva desetljeća provedena su mnoga istraživanja s ciljem potvrde utjecaja virusa na razvoj glioblastoma. Metode: Provedena je retrospektivna studija u vremenskom razdoblju od pet godina. Korištena su arhivska tkiva glioblastoma uklopljena u parafin. Imunohistokemija je rađena za tri virusa: CMV, EBV i HSV-1 pomoću automatiziranog sustava bojenja. Rezultati: Prosječna dob bolesnika u našoj skupini bila je 66,7 ± 8,5 godina. Zabilježena je blaža predominacija oboljelih muškaraca. Dobiveni su negativni imunohistokemijski rezultati za CMV i EBV koji su isključeni iz daljnjeg ispitivanja. Prema IRS procjeni potvrdili smo šest uzoraka HSV-1 koji su ocijenjeni kao IRS 2. Još pet uzoraka HSV-1 ocijenjeno je kao IRS 1 i izuzeti su iz studije. Zaključak: Prema našoj retrospektivnoj studiji i posljedičnim rezultatima, nismo pronašli utjecaj neurotropnih virusa na stopu preživljenja u oboljelih od glioblastoma, no potrebna su daljnja istraživanja koja uključuju širi spektar metoda dokazivanja virusa.
Keywords (english)
Keywords (croatian)
Languageenglish
Languagecroatian
Publication typeScientific paper - Original scientific paper
Publication statusPublished
Peer reviewPeer review - international
Publication versionPublished version
Journal titleActa clinica Croatica
Numberingvol. 61, no. 3, pp. 476-481
p-ISSN0353-9466
e-ISSN1333-9451
DOIhttps://doi.org/10.20471/acc.2022.61.03.12
URN:NBNurn:nbn:hr:220:026625
Publication2022
Document URLhttps://hrcak.srce.hr/296142
Type of resourceText
Access conditionsOpen access
Terms of useLicence Attribution-NonCommercial-NoDerivatives 4.0 International (CC BY-NC-ND 4.0) icon
Created on2024-06-24 08:59:33