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Scientific paper - Case study
The Risk of Multiple Intracranial Aneurysm Formation in Patients with Malignant Disease Undergoing Radiation Therapy: a Case Report and Literature Review
Acta clinica Croatica, 59 (2020), 2; 359-364. https://doi.org/10.20471/acc.2020.59.02.21
Rotim, Krešimir; Splavski, Bruno; Trkanjec, Zlatko; Kalousek, Vladimir; Rotim, Ante; Sajko, Tomislav

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Rotim, K., Splavski, B., Trkanjec, Z., Kalousek, V., Rotim, A. & Sajko, T. (2020). The Risk of Multiple Intracranial Aneurysm Formation in Patients with Malignant Disease Undergoing Radiation Therapy: a Case Report and Literature Review. Acta clinica Croatica, 59. (2), 359-364. doi: 10.20471/acc.2020.59.02.21

Rotim, Krešimir, et al. "The Risk of Multiple Intracranial Aneurysm Formation in Patients with Malignant Disease Undergoing Radiation Therapy: a Case Report and Literature Review." Acta clinica Croatica, vol. 59, no. 2, 2020, pp. 359-364. https://doi.org/10.20471/acc.2020.59.02.21

Rotim, Krešimir, Bruno Splavski, Zlatko Trkanjec, Vladimir Kalousek, Ante Rotim and Tomislav Sajko. "The Risk of Multiple Intracranial Aneurysm Formation in Patients with Malignant Disease Undergoing Radiation Therapy: a Case Report and Literature Review." Acta clinica Croatica 59, no. 2 (2020): 359-364. https://doi.org/10.20471/acc.2020.59.02.21

Rotim, K., et al. (2020) 'The Risk of Multiple Intracranial Aneurysm Formation in Patients with Malignant Disease Undergoing Radiation Therapy: a Case Report and Literature Review', Acta clinica Croatica, 59(2), pp. 359-364. doi: 10.20471/acc.2020.59.02.21

Rotim K, Splavski B, Trkanjec Z, Kalousek V, Rotim A, Sajko T. The Risk of Multiple Intracranial Aneurysm Formation in Patients with Malignant Disease Undergoing Radiation Therapy: a Case Report and Literature Review. Acta clinica Croatica [Internet]. 2020 [cited 2024 October 26];59(2):359-364. doi: 10.20471/acc.2020.59.02.21

K. Rotim, B. Splavski, Z. Trkanjec, V. Kalousek, A. Rotim and T. Sajko, "The Risk of Multiple Intracranial Aneurysm Formation in Patients with Malignant Disease Undergoing Radiation Therapy: a Case Report and Literature Review", Acta clinica Croatica, vol. 59, no. 2, pp. 359-364, 2020. [Online]. Available at: https://urn.nsk.hr/urn:nbn:hr:220:174766. [Accessed: 26 October 2024]

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Metadata
Title (english)The Risk of Multiple Intracranial Aneurysm Formation in Patients with Malignant Disease Undergoing Radiation Therapy: a Case Report and Literature Review
Title (croatian)Rizik nastanka višestrukih intrakranijskih aneurizmi u iradijacijski liječenih bolesnika s malignom bolešću: prikaz slučaja i pregled literature
AuthorKrešimir Rotim
AuthorBruno Splavski https://orcid.org/0000-0002-4483-9364
AuthorZlatko Trkanjec
AuthorVladimir Kalousek
AuthorAnte Rotim
AuthorTomislav Sajko
Author's institution(Sestre milosrdnice University Hospital Center)
Scientific / art field,
discipline and subdiscipline		BIOMEDICINE AND HEALTHCARE
Clinical Medical Sciences
Neurology
Abstract (english)
Neoplastic etiology of intracranial cerebral aneurysm is rare. Yet, the risk of its development is higher in malignant tumor patients receiving radiation therapy. Due to the possible negative effects of irradiation on intracranial vessel walls, the risk of aneurysm formation after radiation therapy, which is crucial for some types of breast cancer patients, continues to be a matter of debate. The aim of this study was to evaluate the hazard of multiple intracranial aneurysm development in patients with malignant disease undergoing radiation therapy. It is based on literature review and case report of a 77-year-old female patient who underwent surgery for multifocal invasive hormone-receptor positive ductal breast carcinoma of no special type, followed by chemotherapy, adjuvant radiation and hormone therapy. Her comorbidity included arterial hypertension and type 2 diabetes. Six unruptured intracranial aneurysms of different bilateral locations were diagnosed incidentally by multi-slice computed tomography angiography and digital subtraction angiography of cerebral vessels. Due to the bilateral aneurysm multiplicity, tumor characteristics and prognosis, comorbidity and relatively advanced age, the patient was not selected for active endovascular or microsurgical aneurysm treatment but only periodical clinical, oncologic and radiological follow-up was advised. In conclusion, the risk of multiple intracranial aneurysm formation in patients with breast cancer undergoing radiation therapy is low, but still possible. Long-term follow-up and regular cerebral angiographic check-up studies are necessary in selected malignant patients to decrease such a risk and to evade the worst outcome associated with aneurysm rupture.
Abstract (croatian)
Neoplastička etiologija intrakranijskih aneurizmi je rijetka. Unatoč tomu, rizik za njihov nastanak povećan je u bolesnika s malignim tumorima koji primaju iradijacijsku terapiju. Poslijeoperacijska iradijacija ključna je u liječenju pojedinih tipova karcinoma dojke, ali može imati negativan učinak na stijenku intrakranijskih krvnih žila povećavajući rizik nastanka cerebralnih aneurizmi nakon provedenog zračenja, što je stalni predmet rasprave. Cilj je ovoga rada bio prosuditi rizik nastanka višestrukih intrakranijskih aneurizmi u bolesnice kod koje je provedeno zračenje u svrhu nastavka liječenja maligne bolesti. Rad je temeljen na pregledu literature i prikazu slučaja bolesnice u dobi od 77 godina s tumorom dojke koja je operirana zbog nespecifičnog tipa multifokalnog, invazivnog, hormonski aktivnog duktalnog karcinoma nakon čega su provedeni kemoterapija, zračenje i hormonska terapija. Bolesnica se je također liječila od arterijske hipertenzije i dijabetesa tipa 2. U bolesnice je pomoću višeslojne kompjutorske tomografske angiografije i digitalne subtrakcijske angiografije moždanih krvnih žila dijagnosticirano šest nerupturiranih intrakranijskih aneurizmi obostrane lokalizacije. Uzimajući u obzir smještaj višestrukiih aneurizmi, kao i osobite značajke tumora i prognozu maligne bolesti te komorbiditet i relativno visoku životnu dob, u bolesnice nije provedeno aktivno endovaskularno ili mikrokirurško liječenje nerupturiranih aneurizmi, nego je preporučeno redovito kliničko, onkološko i radiološko praćenje. Zaključujemo kako je rizik nastanka višestrukih intrakranijskih aneurizmi u bolesnica s karcinomom dojke podvrgnutih iradijacijskom liječenju relativno malen, ali ipak moguć. Stoga su dugotrajno kliničko praćenje i redovita angiografska dijagnostička provjera nužni u selekcioniranih bolesnika kako bi se ovaj rizik umanjio i kako bi se spriječio nepovoljan ishod liječenja nastao uslijed moguće rupture cerebralne aneurizme.
Keywords (english)
Keywords (croatian)
Languageenglish
Languagecroatian
Publication typeScientific paper - Case study
Publication statusPublished
Peer reviewPeer review - international
Publication versionPublished version
Journal titleActa clinica Croatica
Numberingvol. 59, no. 2, pp. 359-364
p-ISSN0353-9466
e-ISSN1333-9451
DOIhttps://doi.org/10.20471/acc.2020.59.02.21
URN:NBNurn:nbn:hr:220:174766
Publication2020
Document URLhttps://hrcak.srce.hr/243698
Type of resourceText
Access conditionsOpen access
Terms of useLicence Attribution-NonCommercial-NoDerivatives 4.0 International (CC BY-NC-ND 4.0) icon
Created on2024-06-25 11:00:10