prikaz prve stranice dokumenta Comparative Targeted Metabolomics of Ischemic Stroke: Thrombi and Serum Profiling for the Identification of Stroke-Related Metabolites
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Scientific paper - Original scientific paper
Comparative Targeted Metabolomics of Ischemic Stroke: Thrombi and Serum Profiling for the Identification of Stroke-Related Metabolites
Biomedicines, 12 (2024), 8; 1731. https://doi.org/10.3390/biomedicines12081731
Karmelić, Ivana; Rubić, Ivana; Starčević, Katarina; Ozretić, David; Poljaković, Zdravka; Jurilj Sajko, Mia; Kalousek, Vladimir; Kalanj, Rafaela; Rešetar Maslov, Dina; Kuleš, Josipa; Roje Bedeković, Marina; Sajko, Tomislav; Rotim, Krešimir; Mrljak, Vladimir; Fabris, Dragana More authors...

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Karmelić, I., Rubić, I., Starčević, K., Ozretić, D., Poljaković, Z., Jurilj Sajko, M. ... Fabris, D. (2024). Comparative Targeted Metabolomics of Ischemic Stroke: Thrombi and Serum Profiling for the Identification of Stroke-Related Metabolites. Biomedicines, 12. (8). doi: 10.3390/biomedicines12081731

Karmelić, Ivana, et al. "Comparative Targeted Metabolomics of Ischemic Stroke: Thrombi and Serum Profiling for the Identification of Stroke-Related Metabolites." Biomedicines, vol. 12, no. 8, 2024. https://doi.org/10.3390/biomedicines12081731

Karmelić, Ivana, Ivana Rubić, Katarina Starčević, David Ozretić, Zdravka Poljaković, Mia Jurilj Sajko, Vladimir Kalousek, et al. "Comparative Targeted Metabolomics of Ischemic Stroke: Thrombi and Serum Profiling for the Identification of Stroke-Related Metabolites." Biomedicines 12, no. 8 (2024). https://doi.org/10.3390/biomedicines12081731

Karmelić, I., et al. (2024) 'Comparative Targeted Metabolomics of Ischemic Stroke: Thrombi and Serum Profiling for the Identification of Stroke-Related Metabolites', Biomedicines, 12(8). doi: 10.3390/biomedicines12081731

Karmelić I, Rubić I, Starčević K, Ozretić D, Poljaković Z, Jurilj Sajko M, and sur.. Comparative Targeted Metabolomics of Ischemic Stroke: Thrombi and Serum Profiling for the Identification of Stroke-Related Metabolites. Biomedicines [Internet]. 2024 [cited 2024 December 09];12(8). doi: 10.3390/biomedicines12081731

I. Karmelić, et al., "Comparative Targeted Metabolomics of Ischemic Stroke: Thrombi and Serum Profiling for the Identification of Stroke-Related Metabolites", Biomedicines, vol. 12, no. 8, 2024. [Online]. Available at: https://urn.nsk.hr/urn:nbn:hr:220:745153. [Accessed: 09 December 2024]

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Metadata
Title (english)Comparative Targeted Metabolomics of Ischemic Stroke: Thrombi and Serum Profiling for the Identification of Stroke-Related Metabolites
AuthorIvana Karmelić
AuthorIvana Rubić
AuthorKatarina Starčević
AuthorDavid Ozretić
AuthorZdravka Poljaković
AuthorMia Jurilj Sajko
AuthorVladimir Kalousek
AuthorRafaela Kalanj
AuthorDina Rešetar Maslov
AuthorJosipa Kuleš
AuthorMarina Roje Bedeković
AuthorTomislav Sajko
AuthorKrešimir Rotim
AuthorVladimir Mrljak
AuthorDragana Fabris
Author's institution(Sestre milosrdnice University Hospital Center)
Scientific / art field,
discipline and subdiscipline		BIOMEDICINE AND HEALTHCARE
Clinical Medical Sciences
Neurology
Abstract (english)
Ischemic stroke is one of the leading causes of death and permanent disability in the world. Rapid diagnosis and intervention are crucial for reducing its consequences on individuals and societies. Therefore, identifying reliable biomarkers for early detection, prognostics, and therapy can facilitate the early prediction and prevention of stroke. Metabolomics has been shown as a promising tool for biomarker discovery since many post-ischemic metabolites can be found in the plasma or serum of the patient. In this research, we performed a comparative targeted metabolomic analysis of stroke thrombi, stroke patient serums, and healthy control serums in order to determine the alteration in the patients’ metabolomes, which might serve as biomarkers for early prediction or stroke prevention. The most statistically altered metabolites characterized in the patient serums compared with the control serums were glutamate and serotonin, followed by phospholipids and triacylglycerols. In stroke thrombi compared with the patients’ serums, the most significantly altered metabolites were classified as lipids, with choline-containing phospholipids and sphingomyelins having the highest discriminatory score. The results of this preliminary study could help in understanding the roles of different metabolic changes that occur during thrombosis and cerebral ischemia and possibly suggest new metabolic biomarkers for ischemic stroke.
Keywords (english)
Languageenglish
Publication typeScientific paper - Original scientific paper
Publication statusPublished
Peer reviewPeer review
Publication versionPublished version
Journal titleBiomedicines
Numberingvol. 12, no. 8, 1731
p-ISSN2227-9059
DOIhttps://doi.org/10.3390/biomedicines12081731
URN:NBNurn:nbn:hr:220:745153
Publication2024
Document URLhttps://www.mdpi.com/2227-9059/12/8/1731
Type of resourceText
Access conditionsOpen access
Terms of useLicence Attribution 4.0 International (CC BY 4.0) icon
Created on2024-11-14 11:53:29