prikaz prve stranice dokumenta Thyroglobulin Measurement in Needle Aspiration for Detection of Recurrences and Neck Metastases in Patients with Differentiated Thyroid Carcinoma: Significance of Anti-Tg Antibodies
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Scientific paper - Original scientific paper
Thyroglobulin Measurement in Needle Aspiration for Detection of Recurrences and Neck Metastases in Patients with Differentiated Thyroid Carcinoma: Significance of Anti-Tg Antibodies
Acta clinica Croatica, 59 (2020), Suppl. 1; 9-17. https://doi.org/10.20471/acc.2020.59.s1.01
Blažeković, Ivan; Romić, Matija; Bosak Butković, Marija; Šiško Markoš, Ines; Gladić Nenadić, Vedrana; Vidranski, Valentina; Petranović Ovčariček, Petra; Krilić, Dražena; Varjačić, Tea; Staničić, Josip; Granić, Roko; Punda, Marija; Mihaljević, Ivan; Jukić, Tomislav; Franceschi, Maja More authors...

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Blažeković, I., Romić, M., Bosak Butković, M., Šiško Markoš, I., Gladić Nenadić, V., Vidranski, V. ... Franceschi, M. (2020). Thyroglobulin Measurement in Needle Aspiration for Detection of Recurrences and Neck Metastases in Patients with Differentiated Thyroid Carcinoma: Significance of Anti-Tg Antibodies. Acta clinica Croatica, 59. (Suppl. 1), 9-17. doi: 10.20471/acc.2020.59.s1.01

Blažeković, Ivan, et al. "Thyroglobulin Measurement in Needle Aspiration for Detection of Recurrences and Neck Metastases in Patients with Differentiated Thyroid Carcinoma: Significance of Anti-Tg Antibodies." Acta clinica Croatica, vol. 59, no. Suppl. 1, 2020, pp. 9-17. https://doi.org/10.20471/acc.2020.59.s1.01

Blažeković, Ivan, Matija Romić, Marija Bosak Butković, Ines Šiško Markoš, Vedrana Gladić Nenadić, Valentina Vidranski, Petra Petranović Ovčariček, et al. "Thyroglobulin Measurement in Needle Aspiration for Detection of Recurrences and Neck Metastases in Patients with Differentiated Thyroid Carcinoma: Significance of Anti-Tg Antibodies." Acta clinica Croatica 59, no. Suppl. 1 (2020): 9-17. https://doi.org/10.20471/acc.2020.59.s1.01

Blažeković, I., et al. (2020) 'Thyroglobulin Measurement in Needle Aspiration for Detection of Recurrences and Neck Metastases in Patients with Differentiated Thyroid Carcinoma: Significance of Anti-Tg Antibodies', Acta clinica Croatica, 59(Suppl. 1), pp. 9-17. doi: 10.20471/acc.2020.59.s1.01

Blažeković I, Romić M, Bosak Butković M, Šiško Markoš I, Gladić Nenadić V, Vidranski V, and sur.. Thyroglobulin Measurement in Needle Aspiration for Detection of Recurrences and Neck Metastases in Patients with Differentiated Thyroid Carcinoma: Significance of Anti-Tg Antibodies. Acta clinica Croatica [Internet]. 2020 [cited 2025 March 05];59(Suppl. 1):9-17. doi: 10.20471/acc.2020.59.s1.01

I. Blažeković, et al., "Thyroglobulin Measurement in Needle Aspiration for Detection of Recurrences and Neck Metastases in Patients with Differentiated Thyroid Carcinoma: Significance of Anti-Tg Antibodies", Acta clinica Croatica, vol. 59, no. Suppl. 1, pp. 9-17, 2020. [Online]. Available at: https://urn.nsk.hr/urn:nbn:hr:220:438310. [Accessed: 05 March 2025]

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Title (english)Thyroglobulin Measurement in Needle Aspiration for Detection of Recurrences and Neck Metastases in Patients with Differentiated Thyroid Carcinoma: Significance of Anti-Tg Antibodies
Title (croatian)Određivanje vrijednosti tireoglobulina u citološkom aspiratu u svrhu otkrivanja recidiva i metastaza na vratu u bolesnika s diferenciranim karcinomom štitnjače: značaj anti-Tg protutijela
AuthorIvan Blažeković
AuthorMatija Romić
AuthorMarija Bosak Butković
AuthorInes Šiško Markoš
AuthorVedrana Gladić Nenadić
AuthorValentina Vidranski
AuthorPetra Petranović Ovčariček
AuthorDražena Krilić
AuthorTea Varjačić
AuthorJosip Staničić
AuthorRoko Granić
MBZ: 318880
AuthorMarija Punda
AuthorIvan Mihaljević
AuthorTomislav Jukić
AuthorMaja Franceschi
Author's institution(Sestre milosrdnice University Hospital Center)
Scientific / art field,
discipline and subdiscipline		BIOMEDICINE AND HEALTHCARE
Clinical Medical Sciences
Abstract (english)
The worldwide incidence of differentiated thyroid cancer (DTC) has increased in recent decades, likely due to frequent use of cervical ultrasonography (US) and US-guided fine needle aspiration biopsy (FNA)., US is performed during follow-up after thyroidectomy, and US-guided FNA with cytology is used if suspicious cervical lymph nodes (LN) or thyroid bed masses are detected. Knowing that serum anti-Tg antibodies (sTgAb) affect the use of serum Tg (sTg) as a tumor marker, the aim of our study was to assess the usefulness of Tg determination in needle aspirates (FNA-Tg) in presence of sTgAb. This retrospective study included 149 patients with DTC and 159 aspirations of suspicious LN and thyroid bed masses. As expected, there was a negative correlation between sTg and sTgAb levels (p<0.05), while FNA-Tg levels had a positive correlation with FNATgAb levels (p<0.05). Furthermore, we found a positive correlation between sTg and FNA-Tg levels (p<0.05), but not between sTgAb and FNA-TgAb or sTgAb and FNA-Tg. In conclusion, these results show that FNA-Tg values were not affected by sTgAb and that FNA-Tg measurement were highly effective in detecting cervical DTC metastases. However, combined use with cytology is suggested for neck evaluation because cytology could reveal metastases from other tumor sites.
Abstract (croatian)
Svjetska incidencija diferenciranog karcinoma štitnjače (DTC) u porastu je posljednjih desetljeća najvjerojatnije zbog povećane uporabe ultrazvuka (US) i US vođene aspiracijske biopsije tankom iglom (FNA). Nakon provedene tireoidektomije, onkološko praćenje uključuje US i US vođenu FNA i citološku analizu aspirata ukoliko se otkriju sumnjivi cervikalni limfni čvorovi (LN ) ili tkivo u ležištu štitnjače. Kako je poznato da serumska protutijela na tireoglobulin (sTgAb) utječu na vrijednost serumskog Tg (sTg) kao tumorskog markera, cilj našeg istraživanja je procijeniti korisnost određivanja Tg u aspiratima suspektnih lezija (FNA-Tg) u prisutnosti sTgAb. Ova retrospektivna studija obuhvatila je 149 bolesnika s DTC-om i 159 uzoraka sumnjivih LN ili tkiva u ležištu štitnjače. Očekivano su razine sTg pokazale obrnutu korelaciju s razinom sTgAb (p <0,05), ali su vrijednosti FNA-Tg imale značajnu pozitivnu korelaciju s vrijednošću FNA-TgAb (p <0,05). Našim rezultatima smo pokazali pozitivnu korelaciju vrijednosti sTg i FNA-Tg (p <0,05), ali ne i korelaciju između sTgAb i FNA-TgAb, kao niti sTgAb i FNA-Tg. Zaključujemo da vrijednosti sTgAb ne utječu na FNA-Tg te da je određivanje FNA-Tg visoko učinkovita metoda dijagnostike regionalnih metastaza DTC. Međutim, preporučuje se kombinirana upotreba s citologijom za procjenu suspektnih čvorova vrata jer se citolologijom mogu istodobno otkriti metastaze i drugih tumora.
Keywords (english)
Keywords (croatian)
Languageenglish
Languagecroatian
Publication typeScientific paper - Original scientific paper
Publication statusPublished
Peer reviewPeer review
Publication versionPublished version
Journal titleActa clinica Croatica
Numberingvol. 59, no. Suppl. 1, pp. 9-17
p-ISSN0353-9466
e-ISSN1333-9451
DOIhttps://doi.org/10.20471/acc.2020.59.s1.01
URN:NBNurn:nbn:hr:220:438310
Publication2020
ConferenceTitle: Thyroid cancer
Location: Zagreb, Croatia
Organizer: Croatian Thyroid Society
Organizer: Croatia Society for Head and Neck Tumors
Start date: 2020-11-20
End date: 2020-11-20
Document URLhttps://hrcak.srce.hr/247771
Type of resourceText
Access conditionsOpen access
Terms of useLicence In copyright icon
Created on2025-03-05 11:20:28