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Scientific paper - Original scientific paper
The role of the NY-ESO-1 in the prognosis of gastric cancer
Biomolecules and Biomedicine, 24 (2024), 4; 813-820. https://doi.org/10.17305/bb.2023.9937
Misir, Zvonimir; Glavčić, Goran; Janković, Suzana; Kruljac, Ivan; Čugura-Filipović, Jakša; Čimić, Kristina; Ulamec, Monika

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Misir, Z., Glavčić, G., Janković, S., Kruljac, I., Čugura Filipović, J., Čimić, K. & Ulamec, M. (2024). The role of the NY-ESO-1 in the prognosis of gastric cancer. Biomolecules and Biomedicine, 24. (4), 813-820. doi: 10.17305/bb.2023.9937

Misir, Zvonimir, et al. "The role of the NY-ESO-1 in the prognosis of gastric cancer." Biomolecules and Biomedicine, vol. 24, no. 4, 2024, pp. 813-820. https://doi.org/10.17305/bb.2023.9937

Misir, Zvonimir, Goran Glavčić, Suzana Janković, Ivan Kruljac, Jakša Čugura Filipović, Kristina Čimić and Monika Ulamec. "The role of the NY-ESO-1 in the prognosis of gastric cancer." Biomolecules and Biomedicine 24, no. 4 (2024): 813-820. https://doi.org/10.17305/bb.2023.9937

Misir, Z., et al. (2024) 'The role of the NY-ESO-1 in the prognosis of gastric cancer', Biomolecules and Biomedicine, 24(4), pp. 813-820. doi: 10.17305/bb.2023.9937

Misir Z, Glavčić G, Janković S, Kruljac I, Čugura Filipović J, Čimić K, and sur.. The role of the NY-ESO-1 in the prognosis of gastric cancer. Biomolecules and Biomedicine [Internet]. 2024 [cited 2025 April 02];24(4):813-820. doi: 10.17305/bb.2023.9937

Z. Misir, et al., "The role of the NY-ESO-1 in the prognosis of gastric cancer", Biomolecules and Biomedicine, vol. 24, no. 4, pp. 813-820, 2024. [Online]. Available at: https://urn.nsk.hr/urn:nbn:hr:220:421558. [Accessed: 02 April 2025]

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Metadata
Title (english)The role of the NY-ESO-1 in the prognosis of gastric cancer
AuthorZvonimir Misir
AuthorGoran Glavčić
AuthorSuzana Janković
AuthorIvan Kruljac
AuthorJakša Čugura-Filipović
AuthorKristina Čimić
AuthorMonika Ulamec
Author's institution(Sestre milosrdnice University Hospital Center)
Scientific / art field,
discipline and subdiscipline		BIOMEDICINE AND HEALTHCARE
Clinical Medical Sciences
Surgery
Abstract (english)
Gastric cancer (GC) is one of the most common malignancies worldwide and the fourth leading cause of cancer-related deaths. GC is a multifactorial disease influenced by both environmental and genetic factors. Its most critical features include invasiveness and high metastatic potential. Metastasis is a complex process, and our understanding of the mechanisms involved remains incomplete. Growing evidence suggests that cancer-testis antigens (CTAs) play a crucial role in the metastatic potential... More of various tumors. Several studies have linked CTA expression with lower tumor differentiation, higher metastatic potential, and poor chemotherapy response. New York esophageal squamous cell carcinoma-1 (NY-ESO-1) antigen, part of the CTA group, is expressed in tumor tissues, while its expression in normal tissues is restricted to spermatogonia. This study aimed to determine the expression of NY-ESO-1 in primary adenocarcinoma of the stomach, both with and without metastasis in regional lymph nodes, and to compare it with TNM stage, age, gender, and survival. We analyzed GC tissue from 53 node-negative and 55 node-positive primary gastric carcinoma patients for NY-ESO-1 expression using immunohistochemical assay. The results were correlated with clinicopathological parameters and survival. Patients with positive NY-ESO-1 expression in primary tumors had a median survival of 19.0 months (range 14.1–24.0), in contrast to those with negative expression, who had a median survival of 52.0 months (range 0.0–133.3) (chi-square 7.99, P = 0.005). T status, N status, and NY-ESO-1 expression were all independently associated with shorter survival. No significant difference in NY-ESO-1 expression in primary tumors was observed concerning lymph node metastasis status. In summary, our findings suggest that increased expression of NY-ESO-1 could potentially serve as a prognostic biomarker for GC. Less
Keywords (english)
Languageenglish
Publication typeScientific paper - Original scientific paper
Publication statusPublished
Peer reviewPeer review
Publication versionPublished version
Journal titleBiomolecules and Biomedicine
Numberingvol. 24, no. 4, pp. 813-820
p-ISSN2831-0896
e-ISSN2831-090X
DOIhttps://doi.org/10.17305/bb.2023.9937
URN:NBNurn:nbn:hr:220:421558
Publication2024
Document URLhttps://www.bjbms.org/ojs/index.php/bjbms/article/view/9937
Type of resourceText
Access conditionsOpen access
Terms of useLicence Attribution 4.0 International (CC BY 4.0) icon
Created on2025-03-14 13:30:55
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