prikaz prve stranice dokumenta Expression of NEDD9 and connexin-43 in neoplastic and stromal cells of gastric adenocarcinoma
  Download
PDF 605.58 KB
Scientific paper - Original scientific paper
Expression of NEDD9 and connexin-43 in neoplastic and stromal cells of gastric adenocarcinoma
Bosnian Journal of Basic Medical Sciences, 21 (2021), 5; 542-548. https://doi.org/10.17305/bjbms.2020.5379
Lerotić, Ivan; Vuković, Petra; Hrabar, Davor; Misir, Zvonimir; Kruljac, Ivan; Forgač, Jelena; Ćaćić, Petra; Pavić, Tajana; Ulamec, Monika

Citations:
,
Cite this document

Lerotić, I., Vuković, P., Hrabar, D., Misir, Z., Kruljac, I., Forgač, J. ... Ulamec, M. (2021). Expression of NEDD9 and connexin-43 in neoplastic and stromal cells of gastric adenocarcinoma. Bosnian Journal of Basic Medical Sciences, 21. (5), 542-548. doi: 10.17305/bjbms.2020.5379

Lerotić, Ivan, et al. "Expression of NEDD9 and connexin-43 in neoplastic and stromal cells of gastric adenocarcinoma." Bosnian Journal of Basic Medical Sciences, vol. 21, no. 5, 2021, pp. 542-548. https://doi.org/10.17305/bjbms.2020.5379

Lerotić, Ivan, Petra Vuković, Davor Hrabar, Zvonimir Misir, Ivan Kruljac, Jelena Forgač, Petra Ćaćić, Tajana Pavić and Monika Ulamec. "Expression of NEDD9 and connexin-43 in neoplastic and stromal cells of gastric adenocarcinoma." Bosnian Journal of Basic Medical Sciences 21, no. 5 (2021): 542-548. https://doi.org/10.17305/bjbms.2020.5379

Lerotić, I., et al. (2021) 'Expression of NEDD9 and connexin-43 in neoplastic and stromal cells of gastric adenocarcinoma', Bosnian Journal of Basic Medical Sciences, 21(5), pp. 542-548. doi: 10.17305/bjbms.2020.5379

Lerotić I, Vuković P, Hrabar D, Misir Z, Kruljac I, Forgač J, and sur.. Expression of NEDD9 and connexin-43 in neoplastic and stromal cells of gastric adenocarcinoma. Bosnian Journal of Basic Medical Sciences [Internet]. 2021 [cited 2025 April 02];21(5):542-548. doi: 10.17305/bjbms.2020.5379

I. Lerotić, et al., "Expression of NEDD9 and connexin-43 in neoplastic and stromal cells of gastric adenocarcinoma", Bosnian Journal of Basic Medical Sciences, vol. 21, no. 5, pp. 542-548, 2021. [Online]. Available at: https://urn.nsk.hr/urn:nbn:hr:220:414198. [Accessed: 02 April 2025]

Please login to the repository to save this object to your list.
Metadata
Title (english)Expression of NEDD9 and connexin-43 in neoplastic and stromal cells of gastric adenocarcinoma
AuthorIvan Lerotić
AuthorPetra Vuković
AuthorDavor Hrabar
AuthorZvonimir Misir
AuthorIvan Kruljac
AuthorJelena Forgač
AuthorPetra Ćaćić
AuthorTajana Pavić
AuthorMonika Ulamec
Author's institution(Sestre milosrdnice University Hospital Center)
Scientific / art field,
discipline and subdiscipline		BIOMEDICINE AND HEALTHCARE
Clinical Medical Sciences
Internal Medicine
Abstract (english)
Gastric cancer is related to high mortality rates and advanced disease stage at the time of diagnosis. Its carcinogenesis is extensively studied and is associated with genetic and epigenetic changes, changed the interaction between tumor and adjacent stromal cells, and changes in the microenvironment molecule status. Neural precursor cell-expressed developmentally down-regulated 9 (NEDD9) affects different signaling proteins and pathways, apoptosis, adhesion, cell migration, and invasiveness.... More Connexin-43 (Cx43) also assists in intercellular communications and has several channel-independent functions. Aberrant expression of those two gap junction proteins plays an essential role in metastatic processes. Our scope was to detect the expression of Cx43 and NEDD9 in epithelial and stromal gastric cancer compartments and its relation to tumor progression and lymph node metastases. Cancer tissue from 53 cases of node-negative and 55 cases of node-positive primary gastric carcinoma patients was analyzed for Cx43 and NEDD9 expression by immunohistochemical assay, and the results were correlated with the remaining clinical and pathological findings and survival. In our cohort of patients with lymph node metastases, we detected higher expression of epithelial Cx43 in the primary tumor and stromal Cx43 expression correlated with both epithelial NEDD9 (rho = 0.453) and stromal NEDD9 (rho = 0.484). Higher epithelial Cx43 and NEDD9 expression were associated with higher mortality (HR 1.54, 95% CI 1.01-2.37, p = 0.048). Epithelial Cx43 expression, both epithelial and stromal NEDD9 expression, T and N status were all independently associated with shorter survival. In summary, our findings suggest that increased expression of both epithelial and stromal NEDD9 and epithelial Cx43 could potentially be used as prognostic gastric cancer biomarkers. Less
Keywords (english)
Languageenglish
Publication typeScientific paper - Original scientific paper
Publication statusPublished
Peer reviewPeer review
Publication versionPublished version
Journal titleBosnian Journal of Basic Medical Sciences
Numberingvol. 21, no. 5, pp. 542-548
p-ISSN1512-8601
DOIhttps://doi.org/10.17305/bjbms.2020.5379
URN:NBNurn:nbn:hr:220:414198
Publication2021
Document URLhttps://www.bjbms.org/ojs/index.php/bjbms/article/view/5379
Type of resourceText
Access conditionsOpen access
Terms of useLicence Attribution 4.0 International (CC BY 4.0) icon
Created on2025-03-17 08:49:27
accessibility

closeAccessibilityrefresh

If you wish to permanently save changes, click on Save, if not - your settings will be reset when you restart the browser.