prikaz prve stranice dokumenta Microsatellite instability-high gastric cancer patients may benefit from adjuvant radiotherapy
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Scientific paper - Original scientific paper
Microsatellite instability-high gastric cancer patients may benefit from adjuvant radiotherapy
Libri Oncologici : Croatian Journal of Oncology, 51 (2023), 2-3; 71-75. https://doi.org/10.20471/LO.2023.51.02-03.11
Janković, Suzana; Ramić, Snježana; Kelava, Tomislav; Misir, Zvonimir; Kirac, Iva; Glavčić, Goran; Filipović-Čugura, Jakša

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Janković, S., Ramić, S., Kelava, T., Misir, Z., Kirac, I., Glavčić, G. & Filipović Čugura, J. (2023). Microsatellite instability-high gastric cancer patients may benefit from adjuvant radiotherapy. Libri Oncologici : Croatian Journal of Oncology, 51. (2-3), 71-75. doi: 10.20471/LO.2023.51.02-03.11

Janković, Suzana, et al. "Microsatellite instability-high gastric cancer patients may benefit from adjuvant radiotherapy." Libri Oncologici : Croatian Journal of Oncology, vol. 51, no. 2-3, 2023, pp. 71-75. https://doi.org/10.20471/LO.2023.51.02-03.11

Janković, Suzana, Snježana Ramić, Tomislav Kelava, Zvonimir Misir, Iva Kirac, Goran Glavčić and Jakša Filipović Čugura. "Microsatellite instability-high gastric cancer patients may benefit from adjuvant radiotherapy." Libri Oncologici : Croatian Journal of Oncology 51, no. 2-3 (2023): 71-75. https://doi.org/10.20471/LO.2023.51.02-03.11

Janković, S., et al. (2023) 'Microsatellite instability-high gastric cancer patients may benefit from adjuvant radiotherapy', Libri Oncologici : Croatian Journal of Oncology, 51(2-3), pp. 71-75. doi: 10.20471/LO.2023.51.02-03.11

Janković S, Ramić S, Kelava T, Misir Z, Kirac I, Glavčić G, and sur.. Microsatellite instability-high gastric cancer patients may benefit from adjuvant radiotherapy. Libri Oncologici : Croatian Journal of Oncology [Internet]. 2023 [cited 2025 April 03];51(2-3):71-75. doi: 10.20471/LO.2023.51.02-03.11

S. Janković, et al., "Microsatellite instability-high gastric cancer patients may benefit from adjuvant radiotherapy", Libri Oncologici : Croatian Journal of Oncology, vol. 51, no. 2-3, pp. 71-75, 2023. [Online]. Available at: https://urn.nsk.hr/urn:nbn:hr:220:458762. [Accessed: 03 April 2025]

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Metadata
Title (english)Microsatellite instability-high gastric cancer patients may benefit from adjuvant radiotherapy
Title (croatian)Zračenje može koristiti pacijentima s karcinomom želuca s visoko izraženom mikrosatelitnom nestabilnosti
AuthorSuzana Janković
AuthorSnježana Ramić
AuthorTomislav Kelava
AuthorZvonimir Misir
AuthorIva Kirac
AuthorGoran Glavčić
AuthorJakša Filipović-Čugura
Author's institution(Sestre milosrdnice University Hospital Center)
Scientific / art field,
discipline and subdiscipline		BIOMEDICINE AND HEALTHCARE
Clinical Medical Sciences
Oncology
Abstract (english)
Gastric cancer remains one of the deadliest types of cancer despite the improvements in therapy regimens. The knowledge about specific molecular and histopathologic features of gastric tumors leads toward targeted therapy protocols. Patients with microsatellite instability-high cancer exhibit special characteristics regarding the response to therapy. These patients benefit from specific immunotherapy regimens and respond poorly to conventional therapy. Our study aimed to evaluate the effect of... More chemotherapy and chemoradiotherapy on the survival of patients with microsatellite instability gastric cancer in our institution. The results of our study show an increase in survival in the microsatellite instability-high group of patients who received radiotherapy (p=0.04). Since all the recent studies recommend radiotherapy only in patients with incompletely resected disease or those with less than D2 lymphadenectomy, our study offers a novelty suggestion in consideration of therapeutic options. If the benefit of radiotherapy can be confirmed in a larger sample of patients, radiotherapy could be a part of tailored therapy for microsatellite instability-high (MSI-H) gastric cancer. Less
Abstract (croatian)
Karcinom želuca jedan je od najsmrtonosnijih karcinoma usprkos napretku u njegovom liječenju. Spoznaje o specifičnim molekularnim i histopatološkim značajkama tumora želuca vode nas prema ciljanim terapijskim protokolima. Pacijenti s karcinomom želuca s visoko izraženom mikrosatelitnom nestabilnosti pokazuju posebne značajke u odgovoru na terapiju. Ovi pacijenti dobro reagiraju na specifične imunoterapijske režime, ali imaju loš odgovor na konvencionalnu terapiju. Cilj našeg istraživanja je... More bila procjena učinka kemoterapije i kemoradioterapije na preživljenje pacijenta s karcinomom želuca s izraženom mikrosatelitnom nestabilnošću u našoj ustanovi. Rezultati naše studije pokazuju produljenje preživljenja u skupini pacijenata s visoko izraženom mikrosatelitnom nestabilnošću koji u primili radioterapiju (p=0.04). S obzirom da sva recentna istraživanja preporučuju zračenje samo pacijentima s nepotpuno reseciranim tumorom ili onima kod kojih je učinjeno manje od D2 limfadenektomije, naše istraživanje donosi moguću novost u razmatranju terapijskih opcija. U slučaju potvrde pozitivnog učinka zračenja u studijama s većim brojem pacijenata, radioterapija bi mogla postati dio ciljane terapije za karcinome želuca s visoko izraženom mikrosatelitnom nestabilnšću. Less
Keywords (english)
Keywords (croatian)
Languageenglish
Languagecroatian
Publication typeScientific paper - Original scientific paper
Publication statusPublished
Peer reviewPeer review
Publication versionPublished version
Journal titleLibri Oncologici : Croatian Journal of Oncology
Numberingvol. 51, no. 2-3, pp. 71-75
p-ISSN0300-8142
e-ISSN2584-3826
DOIhttps://doi.org/10.20471/LO.2023.51.02-03.11
URN:NBNurn:nbn:hr:220:458762
Publication2023
Document URLhttps://hrcak.srce.hr/314269
Type of resourceText
Access conditionsOpen access
Terms of useLicence Attribution-NonCommercial-NoDerivatives 4.0 International (CC BY-NC-ND 4.0) icon
Created on2025-03-19 12:17:38
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