prikaz prve stranice dokumenta Rapid Decrease in High Titer of Factor VIII Inhibitors upon Immunosuppressive Treatment in Severe Postpartum Acquired Hemophilia A
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Scientific paper - Case study
Rapid Decrease in High Titer of Factor VIII Inhibitors upon Immunosuppressive Treatment in Severe Postpartum Acquired Hemophilia A
Croatian Medical Journal, 45 (2004), 2; 213-216. urn:nbn:hr:220:082211
Pejša, Vlatko; Grgurević, Ivica; Kušec, Rajko; Gaćina, Petar

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Pejša, V., Grgurević, I., Kušec, R. & Gaćina, P. (2004). Rapid Decrease in High Titer of Factor VIII Inhibitors upon Immunosuppressive Treatment in Severe Postpartum Acquired Hemophilia A. Croatian Medical Journal, 45. (2), 213-216. Retrieved from https://urn.nsk.hr/urn:nbn:hr:220:082211

Pejša, Vlatko, et al. "Rapid Decrease in High Titer of Factor VIII Inhibitors upon Immunosuppressive Treatment in Severe Postpartum Acquired Hemophilia A." Croatian Medical Journal, vol. 45, no. 2, 2004, pp. 213-216. https://urn.nsk.hr/urn:nbn:hr:220:082211

Pejša, Vlatko, Ivica Grgurević, Rajko Kušec and Petar Gaćina. "Rapid Decrease in High Titer of Factor VIII Inhibitors upon Immunosuppressive Treatment in Severe Postpartum Acquired Hemophilia A." Croatian Medical Journal 45, no. 2 (2004): 213-216. https://urn.nsk.hr/urn:nbn:hr:220:082211

Pejša, V., et al. (2004) 'Rapid Decrease in High Titer of Factor VIII Inhibitors upon Immunosuppressive Treatment in Severe Postpartum Acquired Hemophilia A', Croatian Medical Journal, 45(2), pp. 213-216. Available at: https://urn.nsk.hr/urn:nbn:hr:220:082211 (Accessed 27 January 2025)

Pejša V, Grgurević I, Kušec R, Gaćina P. Rapid Decrease in High Titer of Factor VIII Inhibitors upon Immunosuppressive Treatment in Severe Postpartum Acquired Hemophilia A. Croatian Medical Journal [Internet]. 2004 [cited 2025 January 27];45(2):213-216. Available at: https://urn.nsk.hr/urn:nbn:hr:220:082211

V. Pejša, I. Grgurević, R. Kušec and P. Gaćina, "Rapid Decrease in High Titer of Factor VIII Inhibitors upon Immunosuppressive Treatment in Severe Postpartum Acquired Hemophilia A", Croatian Medical Journal, vol. 45, no. 2, pp. 213-216, 2004. [Online]. Available at: https://urn.nsk.hr/urn:nbn:hr:220:082211. [Accessed: 27 January 2025]

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Metadata
Title (english)Rapid Decrease in High Titer of Factor VIII Inhibitors upon Immunosuppressive Treatment in Severe Postpartum Acquired Hemophilia A
AuthorVlatko Pejša
AuthorIvica Grgurević
AuthorRajko Kušec
AuthorPetar Gaćina
Author's institution(Sestre milosrdnice University Hospital Center)
Scientific / art field,
discipline and subdiscipline		BIOMEDICINE AND HEALTHCARE
Clinical Medical Sciences
Internal Medicine
Abstract (english)
A 25-year-old woman was diagnosed with acquired hemophilia caused by factor VIII (FVIII) inhibitors two months after normal delivery of her first child. She presented with severe spontaneous bleeding in the right forearm and distal part of the right leg. After venipuncture for diagnostic purposes, severe hematoma developed, affecting the whole left arm and shoulder. The diagnosis of acquired hemophilia was confirmed by the presence of FVIII inhibitors (Bethesda units=76), low activity of factor VIII (5%), and prolonged activated partial thromboplastin time (APTT=89 s). The treatment with fresh frozen plasma, cryoprecipitate, red blood cells concentrate, methylprednisolone (3 mg/kg/day for 8 days, then 1mg/kg/day), and cyclophosphamide (150 mg/day for 5 days, then 100 mg/day)was followed by the regression of hematomas and normalization of APTT and FVIII activity. The titer of FVIII inhibitors rapidly decreased and total disappearance of antibodies was achieved after 15 days. To the best of our knowledge, this is the shortest time to the disappearance of inhibitors to FVIII in postpartum acquired hemophilia ever reported. Transient reappearance of inhibitors occurred 10months later and also promptly reacted to the same therapy. In the follow-up period of 4 years, the patient had two more pregnancies with no clinical and laboratory signs of illness recurrence. This case indicates important role of immunosuppressive therapy, which can rapidly induce a remission of this rare condition and be life-saving if introduced early in the course of illness and in doses higher than usually recommended.
Keywords (english)
Languageenglish
Publication typeScientific paper - Case study
Publication statusPublished
Peer reviewPeer review
Publication versionPublished version
Journal titleCroatian Medical Journal
Numberingvol. 45, no. 2, pp. 213-216
p-ISSN0353-9504
e-ISSN1332-8166
URN:NBNurn:nbn:hr:220:082211
Publication2004
Document URLhttp://www.cmj.hr/2004/45/2/15103761.htm
Type of resourceText
Access conditionsOpen access
Terms of useLicence Attribution-NonCommercial-NoDerivatives 4.0 International (CC BY-NC-ND 4.0) icon
Created on2023-01-16 11:01:28