prikaz prve stranice dokumenta Tailoring functional spray-dried powder platform for efficient donepezil nose-to-brain delivery
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Scientific paper - Original scientific paper
Tailoring functional spray-dried powder platform for efficient donepezil nose-to-brain delivery
International Journal of Pharmaceutics, 624 (2022); 1-15. https://doi.org/10.1016/j.ijpharm.2022.122038
Perkušić, Mirna; Nižić Nodilo, Laura; Ugrina, Ivo; Špoljarić, Drago; Jakobušić Brala, Cvijeta; Pepić, Ivan; Lovrić, Jasmina; Matijašić, Gordana; Gretić, Matija; Zadravec, Dijana; Kalogjera, Livije; Hafner, Anita

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Perkušić, M., Nižić Nodilo, L., Ugrina, I., Špoljarić, D., Jakobušić Brala, C., Pepić, I. ... Hafner, A. (2022). Tailoring functional spray-dried powder platform for efficient donepezil nose-to-brain delivery. International Journal of Pharmaceutics, 624., 1-15. doi: 10.1016/j.ijpharm.2022.122038

Perkušić, Mirna, et al. "Tailoring functional spray-dried powder platform for efficient donepezil nose-to-brain delivery." International Journal of Pharmaceutics, vol. 624, 2022, pp. 1-15. https://doi.org/10.1016/j.ijpharm.2022.122038

Perkušić, Mirna, Laura Nižić Nodilo, Ivo Ugrina, Drago Špoljarić, Cvijeta Jakobušić Brala, Ivan Pepić, Jasmina Lovrić, et al. "Tailoring functional spray-dried powder platform for efficient donepezil nose-to-brain delivery." International Journal of Pharmaceutics 624 (2022): 1-15. https://doi.org/10.1016/j.ijpharm.2022.122038

Perkušić, M., et al. (2022) 'Tailoring functional spray-dried powder platform for efficient donepezil nose-to-brain delivery', International Journal of Pharmaceutics, 624, pp. 1-15. doi: 10.1016/j.ijpharm.2022.122038

Perkušić M, Nižić Nodilo L, Ugrina I, Špoljarić D, Jakobušić Brala C, Pepić I, and sur.. Tailoring functional spray-dried powder platform for efficient donepezil nose-to-brain delivery. International Journal of Pharmaceutics [Internet]. 2022 [cited 2024 October 28];624:1-15. doi: 10.1016/j.ijpharm.2022.122038

M. Perkušić, et al., "Tailoring functional spray-dried powder platform for efficient donepezil nose-to-brain delivery", International Journal of Pharmaceutics, vol. 624, pp. 1-15, 2022. [Online]. Available at: https://urn.nsk.hr/urn:nbn:hr:220:145412. [Accessed: 28 October 2024]

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Metadata
Title (english)Tailoring functional spray-dried powder platform for efficient donepezil nose-to-brain delivery
AuthorMirna Perkušić
AuthorLaura Nižić Nodilo
AuthorIvo Ugrina
AuthorDrago Špoljarić
AuthorCvijeta Jakobušić Brala
AuthorIvan Pepić
AuthorJasmina Lovrić
AuthorGordana Matijašić
AuthorMatija Gretić
AuthorDijana Zadravec
AuthorLivije Kalogjera
AuthorAnita Hafner
Author's institution(Sestre milosrdnice University Hospital Center)
Scientific / art field,
discipline and subdiscipline		BIOMEDICINE AND HEALTHCARE
Clinical Medical Sciences
Abstract (english)
Shortcomings of oral donepezil administration in the treatment of Alzheimer’s disease have paved the way for ongoing investigations towards more efficient and safe donepezil nose-to-brain delivery. Herein we present the development of advantageous powder platform for donepezil nose-to-brain delivery, coupling careful design of chitosan and mannitol-based carrier matrix with spray-drying technology advantages and early consideration of adequate nasal administration mode, employing QbD approach. Unprecedentedly, ultrasonic nozzle was used to atomise the drying feed in response to size-related requirements for nasal aerosol particles. The optimised spray drying process resulted in free-flowable dry powder with a great majority of particles larger than 10 µm, ensuring localised nasal deposition upon aerosolization, as evidenced by using 3D-printed nasal cavity model. QbD approach coupling formulation, process and administration parameters enabled optimisation of drug deposition profile reaching tremendously high 65.5 % of the applied dose deposited in the olfactory region. The leading formulation exhibited favourable swelling, mucoadhesion, drug release and permeation-enhancing properties, suiting the needs for efficient brain-targeted delivery. Results of in vitro biocompatibility and physico-chemical stability studies confirmed the leading formulation potential for safe and efficient donepezil nose-to-brain de livery. The obtained results encourage extending the study to an appropriate in vivo model needed for the final proof-of-concept.
Keywords (english)
Languageenglish
Publication typeScientific paper - Original scientific paper
Publication statusPublished
Peer reviewPeer review
Publication versionPublished version
Journal titleInternational Journal of Pharmaceutics
Numberingvol. 624, pp. 1-15
p-ISSN0378-5173
DOIhttps://doi.org/10.1016/j.ijpharm.2022.122038
URN:NBNurn:nbn:hr:220:145412
Publication2022
Document URLhttps://www.sciencedirect.com/science/article/abs/pii/S0378517322005932
Type of resourceText
Access conditionsInstitutional access
Terms of useLicence In copyright icon
Created on2023-12-15 12:34:09