prikaz prve stranice dokumenta Tailoring functional spray-dried powder platform for efficient donepezil nose-to-brain delivery
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Tailoring functional spray-dried powder platform for efficient donepezil nose-to-brain delivery
International Journal of Pharmaceutics, 624 (2022); 1-15. https://doi.org/10.1016/j.ijpharm.2022.122038
Perkušić, Mirna; Nižić Nodilo, Laura; Ugrina, Ivo; Špoljarić, Drago; Jakobušić Brala, Cvijeta; Pepić, Ivan; Lovrić, Jasmina; Matijašić, Gordana; Gretić, Matija; Zadravec, Dijana; Kalogjera, Livije; Hafner, Anita

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Perkušić, M., Nižić Nodilo, L., Ugrina, I., Špoljarić, D., Jakobušić Brala, C., Pepić, I. ... Hafner, A. (2022). Tailoring functional spray-dried powder platform for efficient donepezil nose-to-brain delivery. International Journal of Pharmaceutics, 624., 1-15. doi: 10.1016/j.ijpharm.2022.122038

Perkušić, Mirna, et al. "Tailoring functional spray-dried powder platform for efficient donepezil nose-to-brain delivery." International Journal of Pharmaceutics, vol. 624, 2022, str. 1-15. https://doi.org/10.1016/j.ijpharm.2022.122038

Perkušić, Mirna, Laura Nižić Nodilo, Ivo Ugrina, Drago Špoljarić, Cvijeta Jakobušić Brala, Ivan Pepić, Jasmina Lovrić, et al. "Tailoring functional spray-dried powder platform for efficient donepezil nose-to-brain delivery." International Journal of Pharmaceutics 624 (2022): 1-15. https://doi.org/10.1016/j.ijpharm.2022.122038

Perkušić, M., et al. (2022) 'Tailoring functional spray-dried powder platform for efficient donepezil nose-to-brain delivery', International Journal of Pharmaceutics, 624, str. 1-15. doi: 10.1016/j.ijpharm.2022.122038

Perkušić M, Nižić Nodilo L, Ugrina I, Špoljarić D, Jakobušić Brala C, Pepić I, i sur.. Tailoring functional spray-dried powder platform for efficient donepezil nose-to-brain delivery. International Journal of Pharmaceutics [Internet]. 2022. [pristupljeno 30.10.2024.];624:1-15. doi: 10.1016/j.ijpharm.2022.122038

M. Perkušić, et al., "Tailoring functional spray-dried powder platform for efficient donepezil nose-to-brain delivery", International Journal of Pharmaceutics, vol. 624, str. 1-15, 2022. [Online]. Dostupno na: https://urn.nsk.hr/urn:nbn:hr:220:145412. [Citirano: 30.10.2024.]

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Naslov (engleski)Tailoring functional spray-dried powder platform for efficient donepezil nose-to-brain delivery
AutorMirna Perkušić
AutorLaura Nižić Nodilo
AutorIvo Ugrina
AutorDrago Špoljarić
AutorCvijeta Jakobušić Brala
AutorIvan Pepić
AutorJasmina Lovrić
AutorGordana Matijašić
AutorMatija Gretić
AutorDijana Zadravec
AutorLivije Kalogjera
AutorAnita Hafner
Autorova ustanova(Klinički bolnički centar Sestre milosrdnice)
Znanstveno / umjetničko
područje, polje i grana		BIOMEDICINA I ZDRAVSTVO
Kliničke medicinske znanosti
Sažetak (engleski)
Shortcomings of oral donepezil administration in the treatment of Alzheimer’s disease have paved the way for ongoing investigations towards more efficient and safe donepezil nose-to-brain delivery. Herein we present the development of advantageous powder platform for donepezil nose-to-brain delivery, coupling careful design of chitosan and mannitol-based carrier matrix with spray-drying technology advantages and early consideration of adequate nasal administration mode, employing QbD approach. Unprecedentedly, ultrasonic nozzle was used to atomise the drying feed in response to size-related requirements for nasal aerosol particles. The optimised spray drying process resulted in free-flowable dry powder with a great majority of particles larger than 10 µm, ensuring localised nasal deposition upon aerosolization, as evidenced by using 3D-printed nasal cavity model. QbD approach coupling formulation, process and administration parameters enabled optimisation of drug deposition profile reaching tremendously high 65.5 % of the applied dose deposited in the olfactory region. The leading formulation exhibited favourable swelling, mucoadhesion, drug release and permeation-enhancing properties, suiting the needs for efficient brain-targeted delivery. Results of in vitro biocompatibility and physico-chemical stability studies confirmed the leading formulation potential for safe and efficient donepezil nose-to-brain de livery. The obtained results encourage extending the study to an appropriate in vivo model needed for the final proof-of-concept.
Ključne riječi (engleski)
Jezikengleski
Vrsta publikacijeZnanstveni rad - Izvorni znanstveni rad
Status objaveObjavljen
Vrsta recenzijeRecenziran
Verzija publikacijeObjavljena verzija rada (izdavačev PDF)
Naslov časopisaInternational Journal of Pharmaceutics
Brojčani podacivol. 624, str. 1-15
p-ISSN0378-5173
DOIhttps://doi.org/10.1016/j.ijpharm.2022.122038
URN:NBNurn:nbn:hr:220:145412
Datum objave publikacije2022
URL dokumentahttps://www.sciencedirect.com/science/article/abs/pii/S0378517322005932
Vrsta resursaTekst
Prava pristupaInstitucijski pristup
Uvjeti korištenjaIkona licence Zaštićeno autorskim pravom.
Datum i vrijeme pohrane2023-12-15 12:34:09