prikaz prve stranice dokumenta Corroborating evidence for the correlation between the MTHFR C677T single nucleotide variant and smoking in Croatian subjects independent of ischemic stroke
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Scientific paper - Original scientific paper
Corroborating evidence for the correlation between the MTHFR C677T single nucleotide variant and smoking in Croatian subjects independent of ischemic stroke
Gene Reports, 31 (2023); 101762. https://doi.org/10.1016/j.genrep.2023.101762
Bazina Martinović, Antonela; Križ, Tena; Orešković, Ivana; van Wijnen, Andre J.; Sertić, Jandranka

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Bazina Martinović, A., Križ, T., Orešković, I., van Wijnen, A. J. & Sertić, J. (2023). Corroborating evidence for the correlation between the MTHFR C677T single nucleotide variant and smoking in Croatian subjects independent of ischemic stroke. Gene Reports, 31.. doi: 10.1016/j.genrep.2023.101762

Bazina Martinović, Antonela, et al. "Corroborating evidence for the correlation between the MTHFR C677T single nucleotide variant and smoking in Croatian subjects independent of ischemic stroke." Gene Reports, vol. 31, 2023. https://doi.org/10.1016/j.genrep.2023.101762

Bazina Martinović, Antonela, Tena Križ, Ivana Orešković, Andre J. van Wijnen and Jandranka Sertić. "Corroborating evidence for the correlation between the MTHFR C677T single nucleotide variant and smoking in Croatian subjects independent of ischemic stroke." Gene Reports 31 (2023). https://doi.org/10.1016/j.genrep.2023.101762

Bazina Martinović, A., et al. (2023) 'Corroborating evidence for the correlation between the MTHFR C677T single nucleotide variant and smoking in Croatian subjects independent of ischemic stroke', Gene Reports, 31. doi: 10.1016/j.genrep.2023.101762

Bazina Martinović A, Križ T, Orešković I, van Wijnen AJ, Sertić J. Corroborating evidence for the correlation between the MTHFR C677T single nucleotide variant and smoking in Croatian subjects independent of ischemic stroke. Gene Reports [Internet]. 2023 [cited 2025 April 08];31. doi: 10.1016/j.genrep.2023.101762

A. Bazina Martinović, T. Križ, I. Orešković, A. J. van Wijnen and J. Sertić, "Corroborating evidence for the correlation between the MTHFR C677T single nucleotide variant and smoking in Croatian subjects independent of ischemic stroke", Gene Reports, vol. 31, 2023. [Online]. Available at: https://urn.nsk.hr/urn:nbn:hr:220:116785. [Accessed: 08 April 2025]

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Title (english)Corroborating evidence for the correlation between the MTHFR C677T single nucleotide variant and smoking in Croatian subjects independent of ischemic stroke
AuthorAntonela Bazina Martinović
AuthorTena Križ
AuthorIvana Orešković
AuthorAndre J. van Wijnen
AuthorJandranka Sertić
Author's institution(Sestre milosrdnice University Hospital Center)
Scientific / art field,
discipline and subdiscipline		BIOMEDICINE AND HEALTHCARE
Clinical Medical Sciences
Abstract (english)
Hyperhomocysteinaemia is a risk factor for ischemic stroke development. Single nucleotide variation in the methylenetetrahydrofolate reductase gene (MTHFR, C677T polymorphism, T allele) causes a Ala222Val mutation that is associated with hyperhomocysteinemia, cardiovascular disease and stroke. The homozygous TT genotype of MTHFR may also be linked to tobacco smoking in patients from distinct demographic groups. This study evaluated the association of T allele with smoking in a cohort of 301... More Croatian adults, including 187 healthy controls and 114 patients with ischemic stroke (IS) and proven ischemic cerebral infarction based on Computed Tomography (CT). Exclusion criteria were hemorrhagic cerebral infarction on CT scan, medical history of diabetes mellitus, and age (>60 years). Cholesterol, triglycerides (TG), low-density lipoprotein (LDL), high-density lipoprotein (HDL) and C-reactive protein (CRP) were biochemically analyzed. A positive correlation between the TT genotype of MTHFR and smoking was observed within our entire study cohort (p = 0.011). In the control group, the relative frequency of the TT genotype in smokers is complemented by the prevalence of the CC genotype among non-smokers. Hence, our study with Croatian subjects corroborates previous studies indicating that the TT MTHFR variant is linked to smoking. This positive correlation between the TT genotype and smoking represents a confounding parameter that must be accounted for to permit evaluation of statistical associations with stroke and biochemical markers in blood and single nucleotide variations in the MTHFR gene. Less
Keywords (english)
Languageenglish
Publication typeScientific paper - Original scientific paper
Publication statusPublished
Peer reviewPeer review
Publication versionPublished version
Journal titleGene Reports
Numberingvol. 31, 101762
p-ISSN2452-0144
DOIhttps://doi.org/10.1016/j.genrep.2023.101762
URN:NBNurn:nbn:hr:220:116785
Publication2023
Document URLhttps://www.sciencedirect.com/science/article/pii/S2452014423000249
Type of resourceText
Access conditionsOpen access
Terms of useLicence In copyright icon
Created on2025-03-19 13:40:23
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