prikaz prve stranice dokumenta Corroborating evidence for the correlation between the MTHFR C677T single nucleotide variant and smoking in Croatian subjects independent of ischemic stroke
  Preuzmi
PDF 410.99 KB
Znanstveni rad - Izvorni znanstveni rad
Corroborating evidence for the correlation between the MTHFR C677T single nucleotide variant and smoking in Croatian subjects independent of ischemic stroke
Gene Reports, 31 (2023); 101762. https://doi.org/10.1016/j.genrep.2023.101762
Bazina Martinović, Antonela; Križ, Tena; Orešković, Ivana; van Wijnen, Andre J.; Sertić, Jandranka

Citiranost:
,
Citirajte ovaj rad

Bazina Martinović, A., Križ, T., Orešković, I., van Wijnen, A. J. i Sertić, J. (2023). Corroborating evidence for the correlation between the MTHFR C677T single nucleotide variant and smoking in Croatian subjects independent of ischemic stroke. Gene Reports, 31.. doi: 10.1016/j.genrep.2023.101762

Bazina Martinović, Antonela, et al. "Corroborating evidence for the correlation between the MTHFR C677T single nucleotide variant and smoking in Croatian subjects independent of ischemic stroke." Gene Reports, vol. 31, 2023. https://doi.org/10.1016/j.genrep.2023.101762

Bazina Martinović, Antonela, Tena Križ, Ivana Orešković, Andre J. van Wijnen i Jandranka Sertić. "Corroborating evidence for the correlation between the MTHFR C677T single nucleotide variant and smoking in Croatian subjects independent of ischemic stroke." Gene Reports 31 (2023). https://doi.org/10.1016/j.genrep.2023.101762

Bazina Martinović, A., et al. (2023) 'Corroborating evidence for the correlation between the MTHFR C677T single nucleotide variant and smoking in Croatian subjects independent of ischemic stroke', Gene Reports, 31. doi: 10.1016/j.genrep.2023.101762

Bazina Martinović A, Križ T, Orešković I, van Wijnen AJ, Sertić J. Corroborating evidence for the correlation between the MTHFR C677T single nucleotide variant and smoking in Croatian subjects independent of ischemic stroke. Gene Reports [Internet]. 2023. [pristupljeno 05.04.2025.];31. doi: 10.1016/j.genrep.2023.101762

A. Bazina Martinović, T. Križ, I. Orešković, A. J. van Wijnen i J. Sertić, "Corroborating evidence for the correlation between the MTHFR C677T single nucleotide variant and smoking in Croatian subjects independent of ischemic stroke", Gene Reports, vol. 31, 2023. [Online]. Dostupno na: https://urn.nsk.hr/urn:nbn:hr:220:116785. [Citirano: 05.04.2025.]

Za citiranje koristite ovu mrežnu adresu: https://urn.nsk.hr/urn:nbn:hr:220:116785
Prijavite se u repozitorij kako biste mogli spremiti objekt u svoju listu.
Podaci o radu
Naslov (engleski)Corroborating evidence for the correlation between the MTHFR C677T single nucleotide variant and smoking in Croatian subjects independent of ischemic stroke
AutorAntonela Bazina Martinović
AutorTena Križ
AutorIvana Orešković
AutorAndre J. van Wijnen
AutorJandranka Sertić
Autorova ustanova(Klinički bolnički centar Sestre milosrdnice)
Znanstveno / umjetničko
područje, polje i grana		BIOMEDICINA I ZDRAVSTVO
Kliničke medicinske znanosti
Sažetak (engleski)
Hyperhomocysteinaemia is a risk factor for ischemic stroke development. Single nucleotide variation in the methylenetetrahydrofolate reductase gene (MTHFR, C677T polymorphism, T allele) causes a Ala222Val mutation that is associated with hyperhomocysteinemia, cardiovascular disease and stroke. The homozygous TT genotype of MTHFR may also be linked to tobacco smoking in patients from distinct demographic groups. This study evaluated the association of T allele with smoking in a cohort of 301... Više Croatian adults, including 187 healthy controls and 114 patients with ischemic stroke (IS) and proven ischemic cerebral infarction based on Computed Tomography (CT). Exclusion criteria were hemorrhagic cerebral infarction on CT scan, medical history of diabetes mellitus, and age (>60 years). Cholesterol, triglycerides (TG), low-density lipoprotein (LDL), high-density lipoprotein (HDL) and C-reactive protein (CRP) were biochemically analyzed. A positive correlation between the TT genotype of MTHFR and smoking was observed within our entire study cohort (p = 0.011). In the control group, the relative frequency of the TT genotype in smokers is complemented by the prevalence of the CC genotype among non-smokers. Hence, our study with Croatian subjects corroborates previous studies indicating that the TT MTHFR variant is linked to smoking. This positive correlation between the TT genotype and smoking represents a confounding parameter that must be accounted for to permit evaluation of statistical associations with stroke and biochemical markers in blood and single nucleotide variations in the MTHFR gene. Sakrij dio sažetka
Ključne riječi (engleski)
Jezikengleski
Vrsta publikacijeZnanstveni rad - Izvorni znanstveni rad
Status objaveObjavljen
Vrsta recenzijeRecenziran
Verzija publikacijeObjavljena verzija rada (izdavačev PDF)
Naslov časopisaGene Reports
Brojčani podacivol. 31, 101762
p-ISSN2452-0144
DOIhttps://doi.org/10.1016/j.genrep.2023.101762
URN:NBNurn:nbn:hr:220:116785
Datum objave publikacije2023
URL dokumentahttps://www.sciencedirect.com/science/article/pii/S2452014423000249
Vrsta resursaTekst
Prava pristupaOtvoreni pristup
Uvjeti korištenjaIkona licence Zaštićeno autorskim pravom.
Datum i vrijeme pohrane2025-03-19 13:40:23
accessibility

closePristupačnostrefresh

Ako želite spremiti trajne postavke, kliknite Spremi, ako ne - vaše će se postavke poništiti kad zatvorite preglednik.