prikaz prve stranice dokumenta CD44 expression in human skin: high expression in irritant and allergic contact dermatitis and moderate expression in psoriasis lesions in comparison with healthy controls
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Scientific paper - Original scientific paper
CD44 expression in human skin: high expression in irritant and allergic contact dermatitis and moderate expression in psoriasis lesions in comparison with healthy controls
Contact Dermatitis, 82 (2020); 297-306. https://doi.org/10.1111/cod.13463
Lugović-Mihić, Liborija; Novak-Bilić, Gaby; Vučić, Majda; Japundžić, Iva; Bukvić, Iva

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Lugović Mihić, L., Novak Bilić, G., Vučić, M., Japundžić, I. & Bukvić, I. (2020). CD44 expression in human skin: high expression in irritant and allergic contact dermatitis and moderate expression in psoriasis lesions in comparison with healthy controls. Contact Dermatitis, 82., 297-306. doi: 10.1111/cod.13463

Lugović Mihić, Liborija, et al. "CD44 expression in human skin: high expression in irritant and allergic contact dermatitis and moderate expression in psoriasis lesions in comparison with healthy controls." Contact Dermatitis, vol. 82, 2020, pp. 297-306. https://doi.org/10.1111/cod.13463

Lugović Mihić, Liborija, Gaby Novak Bilić, Majda Vučić, Iva Japundžić and Iva Bukvić. "CD44 expression in human skin: high expression in irritant and allergic contact dermatitis and moderate expression in psoriasis lesions in comparison with healthy controls." Contact Dermatitis 82 (2020): 297-306. https://doi.org/10.1111/cod.13463

Lugović Mihić, L., et al. (2020) 'CD44 expression in human skin: high expression in irritant and allergic contact dermatitis and moderate expression in psoriasis lesions in comparison with healthy controls', Contact Dermatitis, 82, pp. 297-306. doi: 10.1111/cod.13463

Lugović Mihić L, Novak Bilić G, Vučić M, Japundžić I, Bukvić I. CD44 expression in human skin: high expression in irritant and allergic contact dermatitis and moderate expression in psoriasis lesions in comparison with healthy controls. Contact Dermatitis [Internet]. 2020 [cited 2024 December 13];82:297-306. doi: 10.1111/cod.13463

L. Lugović Mihić, G. Novak Bilić, M. Vučić, I. Japundžić and I. Bukvić, "CD44 expression in human skin: high expression in irritant and allergic contact dermatitis and moderate expression in psoriasis lesions in comparison with healthy controls", Contact Dermatitis, vol. 82, pp. 297-306, 2020. [Online]. Available at: https://urn.nsk.hr/urn:nbn:hr:220:473761. [Accessed: 13 December 2024]

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Metadata
Title (english)CD44 expression in human skin: high expression in irritant and allergic contact dermatitis and moderate expression in psoriasis lesions in comparison with healthy controls
AuthorLiborija Lugović-Mihić
MBZ: 215056
AuthorGaby Novak-Bilić
AuthorMajda Vučić
AuthorIva Japundžić
AuthorIva Bukvić
Author's institution(Sestre milosrdnice University Hospital Center)
Scientific / art field,
discipline and subdiscipline		BIOMEDICINE AND HEALTHCARE
Clinical Medical Sciences
Dermatovenerology
Abstract (english)
Background: Previous research using animal models demonstrated that CD44 expression may contribute to directing inflammatory cells into skin lesions during inflammation development in allergic contact dermatitis (ACD). Objectives: To examine CD44 expression in patients with ACD and irritant contact dermatitis (ICD), and to compare it to patients with psoriatic lesions and healthy controls’ (HCs) skin. Methods: This study included 200 patients comprising four groups of 50 each: ACD, ICD, psoriasis vulgaris, and HCs. CD44 expression was determined by immunohistochemical analysis using an optical microscope, and the results were visualized semiquantitatively by determining the percentage of immunoreactive cells in the epidermis, dermis, and on lymphocytes. Results: The highest CD44 expression was found in ICD, followed by ACD, psoriasis vulgaris, and lastly, the HCs (P < .001). Epidermal CD44 expression was significantly higher in contact dermatoses (especially in ICD) compared with psoriasis and healthy skin (P < .001). Similarly, CD44 expression in the dermis and on lymphocytes was strongest in ICD, although less pronounced than in the epidermis. Conclusions: Because significantly elevated CD44 expression in ICD might be related to its function in maintaining and preserving the skin barrier in affected patients, further research on disease pathogenesis and new treatment options is needed.
Keywords (english)
Languageenglish
Publication typeScientific paper - Original scientific paper
Publication statusPublished
Peer reviewUnknown
Publication versionPublished version
Journal titleContact Dermatitis
Numberingvol. 82, pp. 297-306
p-ISSN0105-1873
e-ISSN1600-0536
DOIhttps://doi.org/10.1111/cod.13463
URN:NBNurn:nbn:hr:220:473761
Publication2020
Document URLhttps://onlinelibrary.wiley.com/doi/10.1111/cod.13463
Type of resourceText
Access conditionsInstitutional access
Terms of useLicence In copyright icon
Created on2023-09-25 07:06:02