prikaz prve stranice dokumenta CD44 expression in human skin: high expression in irritant and allergic contact dermatitis and moderate expression in psoriasis lesions in comparison with healthy controls
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CD44 expression in human skin: high expression in irritant and allergic contact dermatitis and moderate expression in psoriasis lesions in comparison with healthy controls
Contact Dermatitis, 82 (2020); 297-306. https://doi.org/10.1111/cod.13463
Lugović-Mihić, Liborija; Novak-Bilić, Gaby; Vučić, Majda; Japundžić, Iva; Bukvić, Iva

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Lugović Mihić, L., Novak Bilić, G., Vučić, M., Japundžić, I. i Bukvić, I. (2020). CD44 expression in human skin: high expression in irritant and allergic contact dermatitis and moderate expression in psoriasis lesions in comparison with healthy controls. Contact Dermatitis, 82., 297-306. doi: 10.1111/cod.13463

Lugović Mihić, Liborija, et al. "CD44 expression in human skin: high expression in irritant and allergic contact dermatitis and moderate expression in psoriasis lesions in comparison with healthy controls." Contact Dermatitis, vol. 82, 2020, str. 297-306. https://doi.org/10.1111/cod.13463

Lugović Mihić, Liborija, Gaby Novak Bilić, Majda Vučić, Iva Japundžić i Iva Bukvić. "CD44 expression in human skin: high expression in irritant and allergic contact dermatitis and moderate expression in psoriasis lesions in comparison with healthy controls." Contact Dermatitis 82 (2020): 297-306. https://doi.org/10.1111/cod.13463

Lugović Mihić, L., et al. (2020) 'CD44 expression in human skin: high expression in irritant and allergic contact dermatitis and moderate expression in psoriasis lesions in comparison with healthy controls', Contact Dermatitis, 82, str. 297-306. doi: 10.1111/cod.13463

Lugović Mihić L, Novak Bilić G, Vučić M, Japundžić I, Bukvić I. CD44 expression in human skin: high expression in irritant and allergic contact dermatitis and moderate expression in psoriasis lesions in comparison with healthy controls. Contact Dermatitis [Internet]. 2020. [pristupljeno 17.11.2024.];82:297-306. doi: 10.1111/cod.13463

L. Lugović Mihić, G. Novak Bilić, M. Vučić, I. Japundžić i I. Bukvić, "CD44 expression in human skin: high expression in irritant and allergic contact dermatitis and moderate expression in psoriasis lesions in comparison with healthy controls", Contact Dermatitis, vol. 82, str. 297-306, 2020. [Online]. Dostupno na: https://urn.nsk.hr/urn:nbn:hr:220:473761. [Citirano: 17.11.2024.]

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Naslov (engleski)CD44 expression in human skin: high expression in irritant and allergic contact dermatitis and moderate expression in psoriasis lesions in comparison with healthy controls
AutorLiborija Lugović-Mihić
MBZ: 215056
AutorGaby Novak-Bilić
AutorMajda Vučić
AutorIva Japundžić
AutorIva Bukvić
Autorova ustanova(Klinički bolnički centar Sestre milosrdnice)
Znanstveno / umjetničko
područje, polje i grana		BIOMEDICINA I ZDRAVSTVO
Kliničke medicinske znanosti
Dermatovenerologija
Sažetak (engleski)
Background: Previous research using animal models demonstrated that CD44 expression may contribute to directing inflammatory cells into skin lesions during inflammation development in allergic contact dermatitis (ACD). Objectives: To examine CD44 expression in patients with ACD and irritant contact dermatitis (ICD), and to compare it to patients with psoriatic lesions and healthy controls’ (HCs) skin. Methods: This study included 200 patients comprising four groups of 50 each: ACD, ICD, psoriasis vulgaris, and HCs. CD44 expression was determined by immunohistochemical analysis using an optical microscope, and the results were visualized semiquantitatively by determining the percentage of immunoreactive cells in the epidermis, dermis, and on lymphocytes. Results: The highest CD44 expression was found in ICD, followed by ACD, psoriasis vulgaris, and lastly, the HCs (P < .001). Epidermal CD44 expression was significantly higher in contact dermatoses (especially in ICD) compared with psoriasis and healthy skin (P < .001). Similarly, CD44 expression in the dermis and on lymphocytes was strongest in ICD, although less pronounced than in the epidermis. Conclusions: Because significantly elevated CD44 expression in ICD might be related to its function in maintaining and preserving the skin barrier in affected patients, further research on disease pathogenesis and new treatment options is needed.
Ključne riječi (engleski)
Jezikengleski
Vrsta publikacijeZnanstveni rad - Izvorni znanstveni rad
Status objaveObjavljen
Vrsta recenzijeNepoznato
Verzija publikacijeObjavljena verzija rada (izdavačev PDF)
Naslov časopisaContact Dermatitis
Brojčani podacivol. 82, str. 297-306
p-ISSN0105-1873
e-ISSN1600-0536
DOIhttps://doi.org/10.1111/cod.13463
URN:NBNurn:nbn:hr:220:473761
Datum objave publikacije2020
URL dokumentahttps://onlinelibrary.wiley.com/doi/10.1111/cod.13463
Vrsta resursaTekst
Prava pristupaInstitucijski pristup
Uvjeti korištenjaIkona licence Zaštićeno autorskim pravom.
Datum i vrijeme pohrane2023-09-25 07:06:02