prikaz prve stranice dokumenta Role of ganglioside biosynthesis genetic polymorphism in cervical cancer development
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Scientific paper - Original scientific paper
Role of ganglioside biosynthesis genetic polymorphism in cervical cancer development
Journal of Obstetrics and Gynaecology, 40 (2020), 8; 1127-1132. https://doi.org/10.1080/01443615.2019.1692801
Danolić, Damir; Heffer, Marija; Wagner, Jasenka; Škrlec, Ivana; Alvir, Ilija; Mamić, Ivica; Šušnjar, Lucija; Banović, Marija; Danolić, Danijela; Puljiz, Mario

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Danolić, D., Heffer, M., Wagner, J., Škrlec, I., Alvir, I., Mamić, I. ... Puljiz, M. (2020). Role of ganglioside biosynthesis genetic polymorphism in cervical cancer development. Journal of Obstetrics and Gynaecology, 40. (8), 1127-1132. doi: 10.1080/01443615.2019.1692801

Danolić, Damir, et al. "Role of ganglioside biosynthesis genetic polymorphism in cervical cancer development." Journal of Obstetrics and Gynaecology, vol. 40, no. 8, 2020, pp. 1127-1132. https://doi.org/10.1080/01443615.2019.1692801

Danolić, Damir, Marija Heffer, Jasenka Wagner, Ivana Škrlec, Ilija Alvir, Ivica Mamić, Lucija Šušnjar, Marija Banović, Danijela Danolić and Mario Puljiz. "Role of ganglioside biosynthesis genetic polymorphism in cervical cancer development." Journal of Obstetrics and Gynaecology 40, no. 8 (2020): 1127-1132. https://doi.org/10.1080/01443615.2019.1692801

Danolić, D., et al. (2020) 'Role of ganglioside biosynthesis genetic polymorphism in cervical cancer development', Journal of Obstetrics and Gynaecology, 40(8), pp. 1127-1132. doi: 10.1080/01443615.2019.1692801

Danolić D, Heffer M, Wagner J, Škrlec I, Alvir I, Mamić I, and sur.. Role of ganglioside biosynthesis genetic polymorphism in cervical cancer development. Journal of Obstetrics and Gynaecology [Internet]. 2020 [cited 2024 June 23];40(8):1127-1132. doi: 10.1080/01443615.2019.1692801

D. Danolić, et al., "Role of ganglioside biosynthesis genetic polymorphism in cervical cancer development", Journal of Obstetrics and Gynaecology, vol. 40, no. 8, pp. 1127-1132, 2020. [Online]. Available at: https://urn.nsk.hr/urn:nbn:hr:220:381770. [Accessed: 23 June 2024]

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Metadata
Title (english)Role of ganglioside biosynthesis genetic polymorphism in cervical cancer development
AuthorDamir Danolić
AuthorMarija Heffer
AuthorJasenka Wagner
AuthorIvana Škrlec
AuthorIlija Alvir
AuthorIvica Mamić
AuthorLucija Šušnjar
AuthorMarija Banović
AuthorDanijela Danolić
AuthorMario Puljiz
Author's institution(Sestre milosrdnice University Hospital Center)
Scientific / art field,
discipline and subdiscipline		BIOMEDICINE AND HEALTHCARE
Clinical Medical Sciences
Gynecology and Obstetrics
Abstract (english)
Cervical cancer is the most common gynaecological cancer in women. Cell mediated immunity plays a significant role in the progression or regression of neoplastic cervical lesions caused by human papilloma virus infection. Engagement of antigen-specific T cell receptors is a prerequisite for T cell activation. The initial events of T cell activation involve the movement of the T cell receptor into specialised microdomains known as lipid rafts. Gangliosides play an active role in the formation, stabilisation and biological functions of lipid rafts. This study aims to determine whether polymorphisms in the genes involved in the biosynthesis of gangliosides represent risk a factor for cervical cancer. Taqman methods for single nucleotide polymorphism genotyping was used. All subjects carried the homozygous wild-type fenotypes for all analysed genes (CC for gene B4GALT5, AA for gene ST3GAL5, AA for gene ST8SIA1 and CC for gene B4GALNT1). A v2 test showed significant differences in genotype failure for B4GALT5 rs138960078 (v2 ¼ 32.02, df ¼ 1, p ¼ .001) and genotype failure for B4GALNT1 rs144643461 (v2 ¼ 41.03, df ¼ 1, p ¼ .001) between cervical cancer group and control group. Genotype failures were significantly more frequent in the cervical cancer group. Unknown adjacent SNPs to rs138960078 in gene B4GALT5 and rs144643461 in gene B4GALNT1 could be associated with cervical cancer development.
Keywords (english)
Languageenglish
Publication typeScientific paper - Original scientific paper
Publication statusPublished
Peer reviewPeer review
Publication versionPublished version
Journal titleJournal of Obstetrics and Gynaecology
Numberingvol. 40, no. 8, pp. 1127-1132
p-ISSN0144-3615
e-ISSN1364-6893
DOIhttps://doi.org/10.1080/01443615.2019.1692801
URN:NBNurn:nbn:hr:220:381770
Publication2020
Document URLhttps://www.tandfonline.com/doi/full/10.1080/01443615.2019.1692801
Type of resourceText
Access conditionsInstitutional access
Terms of useLicence In copyright icon
Created on2024-06-13 12:34:01