prikaz prve stranice dokumenta Role of ganglioside biosynthesis genetic polymorphism in cervical cancer development
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Role of ganglioside biosynthesis genetic polymorphism in cervical cancer development
Journal of Obstetrics and Gynaecology, 40 (2020), 8; 1127-1132. https://doi.org/10.1080/01443615.2019.1692801
Danolić, Damir; Heffer, Marija; Wagner, Jasenka; Škrlec, Ivana; Alvir, Ilija; Mamić, Ivica; Šušnjar, Lucija; Banović, Marija; Danolić, Danijela; Puljiz, Mario

Citirajte ovaj rad

Danolić, D., Heffer, M., Wagner, J., Škrlec, I., Alvir, I., Mamić, I. ... Puljiz, M. (2020). Role of ganglioside biosynthesis genetic polymorphism in cervical cancer development. Journal of Obstetrics and Gynaecology, 40. (8), 1127-1132. doi: 10.1080/01443615.2019.1692801

Danolić, Damir, et al. "Role of ganglioside biosynthesis genetic polymorphism in cervical cancer development." Journal of Obstetrics and Gynaecology, vol. 40, br. 8, 2020, str. 1127-1132. https://doi.org/10.1080/01443615.2019.1692801

Danolić, Damir, Marija Heffer, Jasenka Wagner, Ivana Škrlec, Ilija Alvir, Ivica Mamić, Lucija Šušnjar, Marija Banović, Danijela Danolić i Mario Puljiz. "Role of ganglioside biosynthesis genetic polymorphism in cervical cancer development." Journal of Obstetrics and Gynaecology 40, br. 8 (2020): 1127-1132. https://doi.org/10.1080/01443615.2019.1692801

Danolić, D., et al. (2020) 'Role of ganglioside biosynthesis genetic polymorphism in cervical cancer development', Journal of Obstetrics and Gynaecology, 40(8), str. 1127-1132. doi: 10.1080/01443615.2019.1692801

Danolić D, Heffer M, Wagner J, Škrlec I, Alvir I, Mamić I, i sur.. Role of ganglioside biosynthesis genetic polymorphism in cervical cancer development. Journal of Obstetrics and Gynaecology [Internet]. 2020. [pristupljeno 07.12.2024.];40(8):1127-1132. doi: 10.1080/01443615.2019.1692801

D. Danolić, et al., "Role of ganglioside biosynthesis genetic polymorphism in cervical cancer development", Journal of Obstetrics and Gynaecology, vol. 40, br. 8, str. 1127-1132, 2020. [Online]. Dostupno na: https://urn.nsk.hr/urn:nbn:hr:220:381770. [Citirano: 07.12.2024.]

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Podaci o radu
Naslov (engleski)Role of ganglioside biosynthesis genetic polymorphism in cervical cancer development
AutorDamir Danolić
AutorMarija Heffer
AutorJasenka Wagner
AutorIvana Škrlec
AutorIlija Alvir
AutorIvica Mamić
AutorLucija Šušnjar
AutorMarija Banović
AutorDanijela Danolić
AutorMario Puljiz
Autorova ustanova(Klinički bolnički centar Sestre milosrdnice)
Znanstveno / umjetničko
područje, polje i grana		BIOMEDICINA I ZDRAVSTVO
Kliničke medicinske znanosti
Ginekologija i opstetricija
Sažetak (engleski)
Cervical cancer is the most common gynaecological cancer in women. Cell mediated immunity plays a significant role in the progression or regression of neoplastic cervical lesions caused by human papilloma virus infection. Engagement of antigen-specific T cell receptors is a prerequisite for T cell activation. The initial events of T cell activation involve the movement of the T cell receptor into specialised microdomains known as lipid rafts. Gangliosides play an active role in the formation, stabilisation and biological functions of lipid rafts. This study aims to determine whether polymorphisms in the genes involved in the biosynthesis of gangliosides represent risk a factor for cervical cancer. Taqman methods for single nucleotide polymorphism genotyping was used. All subjects carried the homozygous wild-type fenotypes for all analysed genes (CC for gene B4GALT5, AA for gene ST3GAL5, AA for gene ST8SIA1 and CC for gene B4GALNT1). A v2 test showed significant differences in genotype failure for B4GALT5 rs138960078 (v2 ¼ 32.02, df ¼ 1, p ¼ .001) and genotype failure for B4GALNT1 rs144643461 (v2 ¼ 41.03, df ¼ 1, p ¼ .001) between cervical cancer group and control group. Genotype failures were significantly more frequent in the cervical cancer group. Unknown adjacent SNPs to rs138960078 in gene B4GALT5 and rs144643461 in gene B4GALNT1 could be associated with cervical cancer development.
Ključne riječi (engleski)
Jezikengleski
Vrsta publikacijeZnanstveni rad - Izvorni znanstveni rad
Status objaveObjavljen
Vrsta recenzijeRecenziran
Verzija publikacijeObjavljena verzija rada (izdavačev PDF)
Naslov časopisaJournal of Obstetrics and Gynaecology
Brojčani podacivol. 40, br. 8, str. 1127-1132
p-ISSN0144-3615
e-ISSN1364-6893
DOIhttps://doi.org/10.1080/01443615.2019.1692801
URN:NBNurn:nbn:hr:220:381770
Datum objave publikacije2020
URL dokumentahttps://www.tandfonline.com/doi/full/10.1080/01443615.2019.1692801
Vrsta resursaTekst
Prava pristupaInstitucijski pristup
Uvjeti korištenjaIkona licence Zaštićeno autorskim pravom.
Datum i vrijeme pohrane2024-06-13 12:34:01