prikaz prve stranice dokumenta Plasma Brain-Derived Neurotrophic Factor (BDNF) Concentration and BDNF/TrkB Gene Polymorphisms in Croatian Adults with Asthma
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Scientific paper - Original scientific paper
Plasma Brain-Derived Neurotrophic Factor (BDNF) Concentration and BDNF/TrkB Gene Polymorphisms in Croatian Adults with Asthma
Journal of Personalized Medicine, 10 (2020), 4; 189. https://doi.org/10.3390/jpm10040189
Sreter, Katherina B.; Popovic-Grle, Sanja; Lampalo, Marina; Konjevod, Marcela; Tudor, Lucija; Nikolac Perkovic, Matea; Jukic, Irena; Bingulac-Popovic, Jasna; Safic Stanic, Hana; Markeljevic, Jasenka; Pivac, Nela; Svob Strac, Dubravka

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Sreter, K. B., Popovic Grle, S., Lampalo, M., Konjevod, M., Tudor, L., Nikolac Perkovic, M. ... Svob Strac, D. (2020). Plasma Brain-Derived Neurotrophic Factor (BDNF) Concentration and BDNF/TrkB Gene Polymorphisms in Croatian Adults with Asthma. Journal of Personalized Medicine, 10. (4). doi: 10.3390/jpm10040189

Sreter, Katherina B., et al. "Plasma Brain-Derived Neurotrophic Factor (BDNF) Concentration and BDNF/TrkB Gene Polymorphisms in Croatian Adults with Asthma." Journal of Personalized Medicine, vol. 10, no. 4, 2020. https://doi.org/10.3390/jpm10040189

Sreter, Katherina B., Sanja Popovic Grle, Marina Lampalo, Marcela Konjevod, Lucija Tudor, Matea Nikolac Perkovic, Irena Jukic, et al. "Plasma Brain-Derived Neurotrophic Factor (BDNF) Concentration and BDNF/TrkB Gene Polymorphisms in Croatian Adults with Asthma." Journal of Personalized Medicine 10, no. 4 (2020). https://doi.org/10.3390/jpm10040189

Sreter, K. B., et al. (2020) 'Plasma Brain-Derived Neurotrophic Factor (BDNF) Concentration and BDNF/TrkB Gene Polymorphisms in Croatian Adults with Asthma', Journal of Personalized Medicine, 10(4). doi: 10.3390/jpm10040189

Sreter KB, Popovic Grle S, Lampalo M, Konjevod M, Tudor L, Nikolac Perkovic M, and sur.. Plasma Brain-Derived Neurotrophic Factor (BDNF) Concentration and BDNF/TrkB Gene Polymorphisms in Croatian Adults with Asthma. Journal of Personalized Medicine [Internet]. 2020 October 24 [cited 2024 December 10];10(4). doi: 10.3390/jpm10040189

K. B. Sreter, et al., "Plasma Brain-Derived Neurotrophic Factor (BDNF) Concentration and BDNF/TrkB Gene Polymorphisms in Croatian Adults with Asthma", Journal of Personalized Medicine, vol. 10, no. 4, October 2020. [Online]. Available at: https://urn.nsk.hr/urn:nbn:hr:220:498431. [Accessed: 10 December 2024]

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Metadata
Title (english)Plasma Brain-Derived Neurotrophic Factor (BDNF) Concentration and BDNF/TrkB Gene Polymorphisms in Croatian Adults with Asthma
AuthorKatherina B. Sreter
AuthorSanja Popovic-Grle
AuthorMarina Lampalo
AuthorMarcela Konjevod
AuthorLucija Tudor
AuthorMatea Nikolac Perkovic
AuthorIrena Jukic
AuthorJasna Bingulac-Popovic
AuthorHana Safic Stanic
AuthorJasenka Markeljevic
AuthorNela Pivac
AuthorDubravka Svob Strac
Author's institution(Sestre milosrdnice University Hospital Center)
Scientific / art field,
discipline and subdiscipline		BIOMEDICINE AND HEALTHCARE
Clinical Medical Sciences
Abstract (english)
Brain-derived neurotrophic factor (BDNF) and its tropomyosin-related kinase B (TrkB) receptor might contribute to normal lung functioning and immune responses; however, their role in asthma remains unclear. Plasma BDNF concentrations, as well as BDNF and NTRK2 (TrkB gene) polymorphisms, were investigated in 120 asthma patients and 120 healthy individuals using enzyme-linked immunosorbent assay and polymerase chain reaction, respectively. The genotype and allele frequencies of BDNF Val66Met (rs6265) and NTRK2 rs1439050 polymorphisms did not differ between healthy individuals and asthma patients, nor between patients grouped according to severity or different asthma phenotypes. Although plasma BDNF concentrations were higher among healthy subjects carrying the BDNF Val66Met GG genotype compared to the A allele carriers, such differences were not detected in asthma patients, suggesting the influences of other factors. Plasma BDNF concentration was not affected by NTRK2 rs1439050 polymorphism. Asthma patients had higher plasma BDNF concentrations than control subjects; however, no differences were found between patients subdivided according to asthma severity, or Type-2, allergic, and eosinophilic asthma. Higher plasma BDNF levels were observed in asthma patients with aspirin sensitivity and aspirin-exacerbated respiratory disease. These results suggest that plasma BDNF may serve as a potential peripheral biomarker for asthma, particularly asthma with aspirin sensitivity.
Keywords (english)
Languageenglish
Publication typeScientific paper - Original scientific paper
Publication statusPublished
Peer reviewPeer review
Publication versionPublished version
Journal titleJournal of Personalized Medicine
Numberingvol. 10, no. 4, 189
e-ISSN2075-4426
DOIhttps://doi.org/10.3390/jpm10040189
URN:NBNurn:nbn:hr:220:498431
Publication2020-10-24
Document URLhttps://www.mdpi.com/2075-4426/10/4/189
Type of resourceText
Access conditionsOpen access
Terms of useLicence In copyright icon
Created on2024-09-23 08:55:11