prikaz prve stranice dokumenta Plasma Brain-Derived Neurotrophic Factor (BDNF) Concentration and BDNF/TrkB Gene Polymorphisms in Croatian Adults with Asthma
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Plasma Brain-Derived Neurotrophic Factor (BDNF) Concentration and BDNF/TrkB Gene Polymorphisms in Croatian Adults with Asthma
Journal of Personalized Medicine, 10 (2020), 4; 189. https://doi.org/10.3390/jpm10040189
Sreter, Katherina B.; Popovic-Grle, Sanja; Lampalo, Marina; Konjevod, Marcela; Tudor, Lucija; Nikolac Perkovic, Matea; Jukic, Irena; Bingulac-Popovic, Jasna; Safic Stanic, Hana; Markeljevic, Jasenka; Pivac, Nela; Svob Strac, Dubravka

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Sreter, K. B., Popovic Grle, S., Lampalo, M., Konjevod, M., Tudor, L., Nikolac Perkovic, M. ... Svob Strac, D. (2020). Plasma Brain-Derived Neurotrophic Factor (BDNF) Concentration and BDNF/TrkB Gene Polymorphisms in Croatian Adults with Asthma. Journal of Personalized Medicine, 10. (4). doi: 10.3390/jpm10040189

Sreter, Katherina B., et al. "Plasma Brain-Derived Neurotrophic Factor (BDNF) Concentration and BDNF/TrkB Gene Polymorphisms in Croatian Adults with Asthma." Journal of Personalized Medicine, vol. 10, br. 4, 2020. https://doi.org/10.3390/jpm10040189

Sreter, Katherina B., Sanja Popovic Grle, Marina Lampalo, Marcela Konjevod, Lucija Tudor, Matea Nikolac Perkovic, Irena Jukic, et al. "Plasma Brain-Derived Neurotrophic Factor (BDNF) Concentration and BDNF/TrkB Gene Polymorphisms in Croatian Adults with Asthma." Journal of Personalized Medicine 10, br. 4 (2020). https://doi.org/10.3390/jpm10040189

Sreter, K. B., et al. (2020) 'Plasma Brain-Derived Neurotrophic Factor (BDNF) Concentration and BDNF/TrkB Gene Polymorphisms in Croatian Adults with Asthma', Journal of Personalized Medicine, 10(4). doi: 10.3390/jpm10040189

Sreter KB, Popovic Grle S, Lampalo M, Konjevod M, Tudor L, Nikolac Perkovic M, i sur.. Plasma Brain-Derived Neurotrophic Factor (BDNF) Concentration and BDNF/TrkB Gene Polymorphisms in Croatian Adults with Asthma. Journal of Personalized Medicine [Internet]. 24.10.2020. [pristupljeno 19.12.2024.];10(4). doi: 10.3390/jpm10040189

K. B. Sreter, et al., "Plasma Brain-Derived Neurotrophic Factor (BDNF) Concentration and BDNF/TrkB Gene Polymorphisms in Croatian Adults with Asthma", Journal of Personalized Medicine, vol. 10, br. 4, Listopad 2020. [Online]. Dostupno na: https://urn.nsk.hr/urn:nbn:hr:220:498431. [Citirano: 19.12.2024.]

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Podaci o radu
Naslov (engleski)Plasma Brain-Derived Neurotrophic Factor (BDNF) Concentration and BDNF/TrkB Gene Polymorphisms in Croatian Adults with Asthma
AutorKatherina B. Sreter
AutorSanja Popovic-Grle
AutorMarina Lampalo
AutorMarcela Konjevod
AutorLucija Tudor
AutorMatea Nikolac Perkovic
AutorIrena Jukic
AutorJasna Bingulac-Popovic
AutorHana Safic Stanic
AutorJasenka Markeljevic
AutorNela Pivac
AutorDubravka Svob Strac
Autorova ustanova(Klinički bolnički centar Sestre milosrdnice)
Znanstveno / umjetničko
područje, polje i grana		BIOMEDICINA I ZDRAVSTVO
Kliničke medicinske znanosti
Sažetak (engleski)
Brain-derived neurotrophic factor (BDNF) and its tropomyosin-related kinase B (TrkB) receptor might contribute to normal lung functioning and immune responses; however, their role in asthma remains unclear. Plasma BDNF concentrations, as well as BDNF and NTRK2 (TrkB gene) polymorphisms, were investigated in 120 asthma patients and 120 healthy individuals using enzyme-linked immunosorbent assay and polymerase chain reaction, respectively. The genotype and allele frequencies of BDNF Val66Met (rs6265) and NTRK2 rs1439050 polymorphisms did not differ between healthy individuals and asthma patients, nor between patients grouped according to severity or different asthma phenotypes. Although plasma BDNF concentrations were higher among healthy subjects carrying the BDNF Val66Met GG genotype compared to the A allele carriers, such differences were not detected in asthma patients, suggesting the influences of other factors. Plasma BDNF concentration was not affected by NTRK2 rs1439050 polymorphism. Asthma patients had higher plasma BDNF concentrations than control subjects; however, no differences were found between patients subdivided according to asthma severity, or Type-2, allergic, and eosinophilic asthma. Higher plasma BDNF levels were observed in asthma patients with aspirin sensitivity and aspirin-exacerbated respiratory disease. These results suggest that plasma BDNF may serve as a potential peripheral biomarker for asthma, particularly asthma with aspirin sensitivity.
Ključne riječi (engleski)
Jezikengleski
Vrsta publikacijeZnanstveni rad - Izvorni znanstveni rad
Status objaveObjavljen
Vrsta recenzijeRecenziran
Verzija publikacijeObjavljena verzija rada (izdavačev PDF)
Naslov časopisaJournal of Personalized Medicine
Brojčani podacivol. 10, br. 4, 189
e-ISSN2075-4426
DOIhttps://doi.org/10.3390/jpm10040189
URN:NBNurn:nbn:hr:220:498431
Datum objave publikacije2020-10-24
URL dokumentahttps://www.mdpi.com/2075-4426/10/4/189
Vrsta resursaTekst
Prava pristupaOtvoreni pristup
Uvjeti korištenjaIkona licence Zaštićeno autorskim pravom.
Datum i vrijeme pohrane2024-09-23 08:55:11