prikaz prve stranice dokumenta Synchronous Adie's syndrome and type 1 antineuronal nuclear antibody (anti-Hu)-related paraneoplastic neurological syndromes as predictors of complete response in limited-stage small-cell lung cancer: A case report
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Synchronous Adie's syndrome and type 1 antineuronal nuclear antibody (anti-Hu)-related paraneoplastic neurological syndromes as predictors of complete response in limited-stage small-cell lung cancer: A case report
Molecular and Clinical Oncology, 6 (2017), 6; 921-924. https://doi.org/10.3892/mco.2017.1248
Sreter, Katherina Bernadette; Barisic, Blazenka; Barisic Kutija, Marija; Kukulj, Suzana; Samarzija, Miroslav

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Sreter, K. B., Barisic, B., Barisic Kutija, M., Kukulj, S. i Samarzija, M. (2017). Synchronous Adie's syndrome and type 1 antineuronal nuclear antibody (anti-Hu)-related paraneoplastic neurological syndromes as predictors of complete response in limited-stage small-cell lung cancer: A case report. Molecular and Clinical Oncology, 6. (6), 921-924. doi: 10.3892/mco.2017.1248

Sreter, Katherina Bernadette, et al. "Synchronous Adie's syndrome and type 1 antineuronal nuclear antibody (anti-Hu)-related paraneoplastic neurological syndromes as predictors of complete response in limited-stage small-cell lung cancer: A case report." Molecular and Clinical Oncology, vol. 6, br. 6, 2017, str. 921-924. https://doi.org/10.3892/mco.2017.1248

Sreter, Katherina Bernadette, Blazenka Barisic, Marija Barisic Kutija, Suzana Kukulj i Miroslav Samarzija. "Synchronous Adie's syndrome and type 1 antineuronal nuclear antibody (anti-Hu)-related paraneoplastic neurological syndromes as predictors of complete response in limited-stage small-cell lung cancer: A case report." Molecular and Clinical Oncology 6, br. 6 (2017): 921-924. https://doi.org/10.3892/mco.2017.1248

Sreter, K. B., et al. (2017) 'Synchronous Adie's syndrome and type 1 antineuronal nuclear antibody (anti-Hu)-related paraneoplastic neurological syndromes as predictors of complete response in limited-stage small-cell lung cancer: A case report', Molecular and Clinical Oncology, 6(6), str. 921-924. doi: 10.3892/mco.2017.1248

Sreter KB, Barisic B, Barisic Kutija M, Kukulj S, Samarzija M. Synchronous Adie's syndrome and type 1 antineuronal nuclear antibody (anti-Hu)-related paraneoplastic neurological syndromes as predictors of complete response in limited-stage small-cell lung cancer: A case report. Molecular and Clinical Oncology [Internet]. 06.2017. [pristupljeno 22.11.2024.];6(6):921-924. doi: 10.3892/mco.2017.1248

K. B. Sreter, B. Barisic, M. Barisic Kutija, S. Kukulj i M. Samarzija, "Synchronous Adie's syndrome and type 1 antineuronal nuclear antibody (anti-Hu)-related paraneoplastic neurological syndromes as predictors of complete response in limited-stage small-cell lung cancer: A case report", Molecular and Clinical Oncology, vol. 6, br. 6, str. 921-924, Lipanj 2017. [Online]. Dostupno na: https://urn.nsk.hr/urn:nbn:hr:220:114533. [Citirano: 22.11.2024.]

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Naslov (engleski)Synchronous Adie's syndrome and type 1 antineuronal nuclear antibody (anti-Hu)-related paraneoplastic neurological syndromes as predictors of complete response in limited-stage small-cell lung cancer: A case report
AutorKatherina Bernadette Sreter
AutorBlazenka Barisic
AutorMarija Barisic Kutija
AutorSuzana Kukulj
AutorMiroslav Samarzija
Autorova ustanova(Klinički bolnički centar Sestre milosrdnice)
Znanstveno / umjetničko
područje, polje i grana		BIOMEDICINA I ZDRAVSTVO
Kliničke medicinske znanosti
Sažetak (engleski)
Adie's syndrome (AS) and paraneoplastic sensorimotor neuropathy with cerebellar ataxia (PSN CA) are extremely rare, rapidly progressive, autoimmune diseases associated with the development of antibodies against neuronal-specific Hu proteins that are abnormally expressed in small-cell lung cancer (SCLC). We herein present the unique case of a 55-year-old obese woman, previous heavy smoker, who, during treatment with standard cisplatin-etoposide chemotherapy for limited-stage SCLC, developed simultaneous AS and worsening symptoms consistent with PSN CA that led to significant neurological disability and severe axonal electrophysiological pattern on nerve conduction studies. Serology confirmed the presence of low-titre type 1 antineuronal nuclear antibodies (ANNA-1), previously referred to as anti-Hu antibodies. Following plasmapheresis, immunosuppressive therapy and physical rehabilitation, the neurological symptoms progressively improved. The tumour completely regressed, with no recurrence detected on subsequent radiological examinations. The aim of this case was to highlight the importance of a multidisciplinary team approach for early recognition and rapid treatment of paraneoplastic neurological syndromes (PNS) as key to achieving significant recovery and marked improvement of the neurological deficit. This report extends the literature by confirming earlier studies showing that the presence of serum ANNA-1 in SCLC, an aggressive type of pulmonary carcinoma that is challenging to treat, may portend a more favourable prognosis and response to chemotherapy. Thus, patients with SCLC and new-onset neurological symptoms should be tested for ANNA-1. The role of a multimodality approach to treating PNS is also emphasized.
Ključne riječi (engleski)
Jezikengleski
Vrsta publikacijeZnanstveni rad - Prikaz slučaja
Status objaveObjavljen
Vrsta recenzijeRecenziran
Verzija publikacijeObjavljena verzija rada (izdavačev PDF)
Naslov časopisaMolecular and Clinical Oncology
Brojčani podacivol. 6, br. 6, str. 921-924
p-ISSN2049-9450
e-ISSN2049-9469
DOIhttps://doi.org/10.3892/mco.2017.1248
URN:NBNurn:nbn:hr:220:114533
Datum objave publikacije2017-06
URL dokumentahttps://www.spandidos-publications.com/10.3892/mco.2017.1248
Vrsta resursaTekst
Prava pristupaOtvoreni pristup
Uvjeti korištenjaIkona licence Zaštićeno autorskim pravom.
Datum i vrijeme pohrane2024-10-02 09:15:58