prikaz prve stranice dokumenta Serotonin risk factors for the development of hypertension in pregnancy
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Serotonin risk factors for the development of hypertension in pregnancy
Archives of Gynecology and Obstetrics, 291 (2014), 4; 779-785. https://doi.org/10.1007/s00404-014-3461-8
Sabolovic Rudman, Senka; Mustapic, Maja; Kosec, Vesna; Pivac, Nela; Rudman, Franjo; Muck-Seler, Dorotea

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Sabolovic Rudman, S., Mustapic, M., Kosec, V., Pivac, N., Rudman, F. i Muck Seler, D. (2014). Serotonin risk factors for the development of hypertension in pregnancy. Archives of Gynecology and Obstetrics, 291. (4), 779-785. doi: 10.1007/s00404-014-3461-8

Sabolovic Rudman, Senka, et al. "Serotonin risk factors for the development of hypertension in pregnancy." Archives of Gynecology and Obstetrics, vol. 291, br. 4, 2014, str. 779-785. https://doi.org/10.1007/s00404-014-3461-8

Sabolovic Rudman, Senka, Maja Mustapic, Vesna Kosec, Nela Pivac, Franjo Rudman i Dorotea Muck Seler. "Serotonin risk factors for the development of hypertension in pregnancy." Archives of Gynecology and Obstetrics 291, br. 4 (2014): 779-785. https://doi.org/10.1007/s00404-014-3461-8

Sabolovic Rudman, S., et al. (2014) 'Serotonin risk factors for the development of hypertension in pregnancy', Archives of Gynecology and Obstetrics, 291(4), str. 779-785. doi: 10.1007/s00404-014-3461-8

Sabolovic Rudman S, Mustapic M, Kosec V, Pivac N, Rudman F, Muck Seler D. Serotonin risk factors for the development of hypertension in pregnancy. Archives of Gynecology and Obstetrics [Internet]. 2014. [pristupljeno 08.12.2024.];291(4):779-785. doi: 10.1007/s00404-014-3461-8

S. Sabolovic Rudman, M. Mustapic, V. Kosec, N. Pivac, F. Rudman i D. Muck Seler, "Serotonin risk factors for the development of hypertension in pregnancy", Archives of Gynecology and Obstetrics, vol. 291, br. 4, str. 779-785, 2014. [Online]. Dostupno na: https://urn.nsk.hr/urn:nbn:hr:220:437700. [Citirano: 08.12.2024.]

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Podaci o radu
Naslov (engleski)Serotonin risk factors for the development of hypertension in pregnancy
AutorSenka Sabolovic Rudman
AutorMaja Mustapic
AutorVesna Kosec
AutorNela Pivac
AutorFranjo Rudman
AutorDorotea Muck-Seler
Autorova ustanova(Klinički bolnički centar Sestre milosrdnice)
Znanstveno / umjetničko
područje, polje i grana		BIOMEDICINA I ZDRAVSTVO
Kliničke medicinske znanosti
Sažetak (engleski)
Purpose: To determine platelet serotonin (5-HT) concentrations and genotype and allele frequencies of serotonergic type 2A receptor gene (HTR2A) and 5-HT transporter gene (SLC6A4) in women with pre-eclampsia, gestational hypertension without proteinuria (PIH) and in control normotensive pregnant women. Methods: The study included 96 control women, 131 women with PIH and 84 women with pre-eclampsia (ICD-10 criteria) in the last trimester of pregnancy. Variants of the HTR2A T102C (rs6313) and SLC6A4 (5-HTTLPR and rs25531) were determined by the PCR and real-time PCR procedures. Platelet 5-HT concentrations were analyzed by the spectrofluorimetric method. Results: The frequency of the 5HTTLPR and of HTR2A T102C genotypes or alleles was similar between three groups of pregnant women and was not associated with low platelet 5-HT concentrations observed in pregnant women with PIH or pre-eclampsia. Conclusions: The results confirm alterations in the peripheral 5-HT system in pregnancy-induced hypertension. Low platelet 5-HT concentration is a common feature of both PIH and pre-eclampsia. The results did not support the hypothesis that hypertension in pregnancy is a trait associated with polymorphic variants of the HTR2A and SLC6A4 or that they have a role in the predisposition to hypertensive disorders in pregnancy. The further studies are necessary to elucidate the role of 5-HT and genetic factors in the development of hypertensive disorders in pregnancy.
Ključne riječi (engleski)
Jezikengleski
Vrsta publikacijeZnanstveni rad - Izvorni znanstveni rad
Status objaveObjavljen
Vrsta recenzijeRecenziran
Verzija publikacijeObjavljena verzija rada (izdavačev PDF)
Naslov časopisaArchives of Gynecology and Obstetrics
Brojčani podacivol. 291, br. 4, str. 779-785
p-ISSN0932-0067
e-ISSN1432-0711
DOIhttps://doi.org/10.1007/s00404-014-3461-8
URN:NBNurn:nbn:hr:220:437700
Datum objave publikacije2014
URL dokumentahttp://link.springer.com/10.1007/s00404-014-3461-8
Vrsta resursaTekst
Prava pristupaInstitucijski pristup
Uvjeti korištenjaIkona licence Zaštićeno autorskim pravom.
Datum i vrijeme pohrane2024-10-18 10:18:58