prikaz prve stranice dokumenta The prognostic value of red blood cell characteristics on diabetic retinopathy development and progression in type 2 diabetes mellitus
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The prognostic value of red blood cell characteristics on diabetic retinopathy development and progression in type 2 diabetes mellitus
Clinical hemorheology and microcirculation, 71 (2019), 4; 475-481. https://doi.org/10.3233/ch-180422
Blaslov, Kristina; Kruljac, Ivan; Mirošević, Gorana; Gaćina, Petar; Kolonić, Slobodanka Ostojić; Vrkljan, Milan

Citirajte ovaj rad

Blaslov, K., Kruljac, I., Mirošević, G., Gaćina, P., Kolonić, S. O. i Vrkljan, M. (2019). The prognostic value of red blood cell characteristics on diabetic retinopathy development and progression in type 2 diabetes mellitus. Clinical hemorheology and microcirculation, 71. (4), 475-481. doi: 10.3233/ch-180422

Blaslov, Kristina, et al. "The prognostic value of red blood cell characteristics on diabetic retinopathy development and progression in type 2 diabetes mellitus." Clinical hemorheology and microcirculation, vol. 71, br. 4, 2019, str. 475-481. https://doi.org/10.3233/ch-180422

Blaslov, Kristina, Ivan Kruljac, Gorana Mirošević, Petar Gaćina, Slobodanka Ostojić Kolonić i Milan Vrkljan. "The prognostic value of red blood cell characteristics on diabetic retinopathy development and progression in type 2 diabetes mellitus." Clinical hemorheology and microcirculation 71, br. 4 (2019): 475-481. https://doi.org/10.3233/ch-180422

Blaslov, K., et al. (2019) 'The prognostic value of red blood cell characteristics on diabetic retinopathy development and progression in type 2 diabetes mellitus', Clinical hemorheology and microcirculation, 71(4), str. 475-481. doi: 10.3233/ch-180422

Blaslov K, Kruljac I, Mirošević G, Gaćina P, Kolonić SO, Vrkljan M. The prognostic value of red blood cell characteristics on diabetic retinopathy development and progression in type 2 diabetes mellitus. Clinical hemorheology and microcirculation [Internet]. 2019. [pristupljeno 17.11.2024.];71(4):475-481. doi: 10.3233/ch-180422

K. Blaslov, I. Kruljac, G. Mirošević, P. Gaćina, S. O. Kolonić i M. Vrkljan, "The prognostic value of red blood cell characteristics on diabetic retinopathy development and progression in type 2 diabetes mellitus", Clinical hemorheology and microcirculation, vol. 71, br. 4, str. 475-481, 2019. [Online]. Dostupno na: https://urn.nsk.hr/urn:nbn:hr:220:544502. [Citirano: 17.11.2024.]

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Podaci o radu
Naslov (engleski)The prognostic value of red blood cell characteristics on diabetic retinopathy development and progression in type 2 diabetes mellitus
AutorKristina Blaslov
AutorIvan Kruljac
AutorGorana Mirošević
AutorPetar Gaćina
AutorSlobodanka Ostojić Kolonić
AutorMilan Vrkljan
Autorova ustanova(Klinički bolnički centar Sestre milosrdnice)
Znanstveno / umjetničko
područje, polje i grana		BIOMEDICINA I ZDRAVSTVO
Kliničke medicinske znanosti
Interna medicina
Sažetak (engleski)
BACKGROUND: Although it is considered that the pathogenesis of diabetic retinopathy (DR) in type 2 diabetes mellitus (T2DM) is primarily due to chronic hyperglycemia resulting in vascular changes and retinal ischemia, the red blood cells (RBCs) disorders might also represent an important pathophysiological risk factor. OBJECTIVE: To evaluate whether the RBC properties contribute to DR development and progression in T2DM. METHODS: This prospective observational study comprised 247 persons with T2DM free of DR or with non proliferative DR without any signs of anaemia. The patients were reacessed after 60-months. RESULTS: The mean age of our study population was 56 years, 54.9% males with diabetes duration of 11, 18±1, 28 years. During the follow up, 16 (5.84%) participants developed non proliferative DR and 9 (3.64%) progressed to PDR while the mean corpuscular volume (MCV) and red cell distribution width (RDW) MCV rose. Both MCV and RDW correlated positively with HbA1c (r = 0, 468, p = 0.003 and r = 0.521, p < 0.001), while Cox regression analysis revealed that besides age, diabetes duration, HbA1c, hypertension and dyslipidemia presence, MCV and RDW are also associated with the risk of DR development and progression (HR 1.057 and 1.237, p < 0.001). CONCLUSIONS: We clearly demonstrated that RBC's characteristics might represent a risk factor for DR development and progression.
Ključne riječi (engleski)
Jezikengleski
Vrsta publikacijeZnanstveni rad - Izvorni znanstveni rad
Status objaveObjavljen
Vrsta recenzijeRecenziran - međunarodna recenzija
Verzija publikacijeObjavljena verzija rada (izdavačev PDF)
Naslov časopisaClinical hemorheology and microcirculation
Brojčani podacivol. 71, br. 4, str. 475-481
p-ISSN1386-0291
DOIhttps://doi.org/10.3233/ch-180422
URN:NBNurn:nbn:hr:220:544502
Datum objave publikacije2019
URL dokumentahttps://content.iospress.com/articles/clinical-hemorheology-and-microcirculation/ch180422
Vrsta resursaTekst
Prava pristupaInstitucijski pristup
Uvjeti korištenjaIkona licence Zaštićeno autorskim pravom.
Datum i vrijeme pohrane2023-06-28 07:28:41