prikaz prve stranice dokumenta Effects of Troglitazone and Insulin on Glucose Production in Cultured Hepatocytes Isolated from Rats on High Fat Diet
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Effects of Troglitazone and Insulin on Glucose Production in Cultured Hepatocytes Isolated from Rats on High Fat Diet
Collegium antropologicum, 28 (2004), 2; 631-637. urn:nbn:hr:220:923026
Roša, Jagoda; Pancirov, Helena; Skala, Hana; Gadžić, Alan; Roša, Josip

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Roša, J., Pancirov, H., Skala, H., Gadžić, A. i Roša, J. (2004). Effects of Troglitazone and Insulin on Glucose Production in Cultured Hepatocytes Isolated from Rats on High Fat Diet. Collegium antropologicum, 28. (2), 631-637. Preuzeto s https://urn.nsk.hr/urn:nbn:hr:220:923026

Roša, Jagoda, et al. "Effects of Troglitazone and Insulin on Glucose Production in Cultured Hepatocytes Isolated from Rats on High Fat Diet." Collegium antropologicum, vol. 28, br. 2, 2004, str. 631-637. https://urn.nsk.hr/urn:nbn:hr:220:923026

Roša, Jagoda, Helena Pancirov, Hana Skala, Alan Gadžić i Josip Roša. "Effects of Troglitazone and Insulin on Glucose Production in Cultured Hepatocytes Isolated from Rats on High Fat Diet." Collegium antropologicum 28, br. 2 (2004): 631-637. https://urn.nsk.hr/urn:nbn:hr:220:923026

Roša, J., et al. (2004) 'Effects of Troglitazone and Insulin on Glucose Production in Cultured Hepatocytes Isolated from Rats on High Fat Diet', Collegium antropologicum, 28(2), str. 631-637. Preuzeto s: https://urn.nsk.hr/urn:nbn:hr:220:923026 (Datum pristupa: 08.12.2024.)

Roša J, Pancirov H, Skala H, Gadžić A, Roša J. Effects of Troglitazone and Insulin on Glucose Production in Cultured Hepatocytes Isolated from Rats on High Fat Diet. Collegium antropologicum [Internet]. 2004. [pristupljeno 08.12.2024.];28(2):631-637. Dostupno na: https://urn.nsk.hr/urn:nbn:hr:220:923026

J. Roša, H. Pancirov, H. Skala, A. Gadžić i J. Roša, "Effects of Troglitazone and Insulin on Glucose Production in Cultured Hepatocytes Isolated from Rats on High Fat Diet", Collegium antropologicum, vol. 28, br. 2, str. 631-637, 2004. [Online]. Dostupno na: https://urn.nsk.hr/urn:nbn:hr:220:923026. [Citirano: 08.12.2024.]

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Naslov (engleski)Effects of Troglitazone and Insulin on Glucose Production in Cultured Hepatocytes Isolated from Rats on High Fat Diet
AutorJagoda Roša
AutorHelena Pancirov
AutorHana Skala
AutorAlan Gadžić
AutorJosip Roša
Autorova ustanova(Klinički bolnički centar Sestre milosrdnice)
Znanstveno / umjetničko
područje, polje i grana		BIOMEDICINA I ZDRAVSTVO
Kliničke medicinske znanosti
Interna medicina
Sažetak (engleski)
Increased dietary fat intake in general, and saturated fat specifically, will lead to the impairment of insulin action. The aim of this study was to find out the changes in hepatic glucose output in dependence of fat diet and a possible direct action of insulin and troglitazone in hepatocytes. Hepatocytes were isolated by a collagenase perfusion technique and cultured for 24 h in M 199 serum-free medium. The glucose production in hepatocytes isolated from rats on high fat diet (unsaturated fat) was 79% higher compared to control and even 139% higher than in rats on high-fat diet (saturated fat). Troglitazone significantly decreased the glucose production in hepatocytes obtained from rats on unsaturated fat diet. The troglitazone in presence of insulin totally normalized glucose production but also only in hepatocytes obtained from rats on unsaturated-fat diet. The troglitazone showed an insulinomimetic as well as insulin-sensitizing effect but only in rats on unsaturated-fat diet.
Ključne riječi (engleski)
Jezikengleski
Vrsta publikacijeZnanstveni rad - Izvorni znanstveni rad
Status objaveObjavljen
Vrsta recenzijeRecenziran - međunarodna recenzija
Verzija publikacijeObjavljena verzija rada (izdavačev PDF)
Naslov časopisaCollegium antropologicum
Brojčani podacivol. 28, br. 2, str. 631-637
p-ISSN0350-6134
e-ISSN1848-9486
URN:NBNurn:nbn:hr:220:923026
Datum objave publikacije2004
URL dokumentahttps://hrcak.srce.hr/5587
Vrsta resursaTekst
Prava pristupaOtvoreni pristup
Uvjeti korištenjaIkona licence Zaštićeno autorskim pravom.
Datum i vrijeme pohrane2023-08-21 12:53:25