prikaz prve stranice dokumenta Comparative Targeted Metabolomics of Ischemic Stroke: Thrombi and Serum Profiling for the Identification of Stroke-Related Metabolites
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Comparative Targeted Metabolomics of Ischemic Stroke: Thrombi and Serum Profiling for the Identification of Stroke-Related Metabolites
Biomedicines, 12 (2024), 8; 1731. https://doi.org/10.3390/biomedicines12081731
Karmelić, Ivana; Rubić, Ivana; Starčević, Katarina; Ozretić, David; Poljaković, Zdravka; Jurilj Sajko, Mia; Kalousek, Vladimir; Kalanj, Rafaela; Rešetar Maslov, Dina; Kuleš, Josipa; Roje Bedeković, Marina; Sajko, Tomislav; Rotim, Krešimir; Mrljak, Vladimir; Fabris, Dragana Više autora...

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Karmelić, I., Rubić, I., Starčević, K., Ozretić, D., Poljaković, Z., Jurilj Sajko, M. ... Fabris, D. (2024). Comparative Targeted Metabolomics of Ischemic Stroke: Thrombi and Serum Profiling for the Identification of Stroke-Related Metabolites. Biomedicines, 12. (8). doi: 10.3390/biomedicines12081731

Karmelić, Ivana, et al. "Comparative Targeted Metabolomics of Ischemic Stroke: Thrombi and Serum Profiling for the Identification of Stroke-Related Metabolites." Biomedicines, vol. 12, br. 8, 2024. https://doi.org/10.3390/biomedicines12081731

Karmelić, Ivana, Ivana Rubić, Katarina Starčević, David Ozretić, Zdravka Poljaković, Mia Jurilj Sajko, Vladimir Kalousek, et al. "Comparative Targeted Metabolomics of Ischemic Stroke: Thrombi and Serum Profiling for the Identification of Stroke-Related Metabolites." Biomedicines 12, br. 8 (2024). https://doi.org/10.3390/biomedicines12081731

Karmelić, I., et al. (2024) 'Comparative Targeted Metabolomics of Ischemic Stroke: Thrombi and Serum Profiling for the Identification of Stroke-Related Metabolites', Biomedicines, 12(8). doi: 10.3390/biomedicines12081731

Karmelić I, Rubić I, Starčević K, Ozretić D, Poljaković Z, Jurilj Sajko M, i sur.. Comparative Targeted Metabolomics of Ischemic Stroke: Thrombi and Serum Profiling for the Identification of Stroke-Related Metabolites. Biomedicines [Internet]. 2024. [pristupljeno 16.11.2024.];12(8). doi: 10.3390/biomedicines12081731

I. Karmelić, et al., "Comparative Targeted Metabolomics of Ischemic Stroke: Thrombi and Serum Profiling for the Identification of Stroke-Related Metabolites", Biomedicines, vol. 12, br. 8, 2024. [Online]. Dostupno na: https://urn.nsk.hr/urn:nbn:hr:220:745153. [Citirano: 16.11.2024.]

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Naslov (engleski)Comparative Targeted Metabolomics of Ischemic Stroke: Thrombi and Serum Profiling for the Identification of Stroke-Related Metabolites
AutorIvana Karmelić
AutorIvana Rubić
AutorKatarina Starčević
AutorDavid Ozretić
AutorZdravka Poljaković
AutorMia Jurilj Sajko
AutorVladimir Kalousek
AutorRafaela Kalanj
AutorDina Rešetar Maslov
AutorJosipa Kuleš
AutorMarina Roje Bedeković
AutorTomislav Sajko
AutorKrešimir Rotim
AutorVladimir Mrljak
AutorDragana Fabris
Autorova ustanova(Klinički bolnički centar Sestre milosrdnice)
Znanstveno / umjetničko
područje, polje i grana		BIOMEDICINA I ZDRAVSTVO
Kliničke medicinske znanosti
Neurologija
Sažetak (engleski)
Ischemic stroke is one of the leading causes of death and permanent disability in the world. Rapid diagnosis and intervention are crucial for reducing its consequences on individuals and societies. Therefore, identifying reliable biomarkers for early detection, prognostics, and therapy can facilitate the early prediction and prevention of stroke. Metabolomics has been shown as a promising tool for biomarker discovery since many post-ischemic metabolites can be found in the plasma or serum of the patient. In this research, we performed a comparative targeted metabolomic analysis of stroke thrombi, stroke patient serums, and healthy control serums in order to determine the alteration in the patients’ metabolomes, which might serve as biomarkers for early prediction or stroke prevention. The most statistically altered metabolites characterized in the patient serums compared with the control serums were glutamate and serotonin, followed by phospholipids and triacylglycerols. In stroke thrombi compared with the patients’ serums, the most significantly altered metabolites were classified as lipids, with choline-containing phospholipids and sphingomyelins having the highest discriminatory score. The results of this preliminary study could help in understanding the roles of different metabolic changes that occur during thrombosis and cerebral ischemia and possibly suggest new metabolic biomarkers for ischemic stroke.
Ključne riječi (engleski)
Jezikengleski
Vrsta publikacijeZnanstveni rad - Izvorni znanstveni rad
Status objaveObjavljen
Vrsta recenzijeRecenziran
Verzija publikacijeObjavljena verzija rada (izdavačev PDF)
Naslov časopisaBiomedicines
Brojčani podacivol. 12, br. 8, 1731
p-ISSN2227-9059
DOIhttps://doi.org/10.3390/biomedicines12081731
URN:NBNurn:nbn:hr:220:745153
Datum objave publikacije2024
URL dokumentahttps://www.mdpi.com/2227-9059/12/8/1731
Vrsta resursaTekst
Prava pristupaOtvoreni pristup
Uvjeti korištenjaIkona licence Imenovanje 4.0 međunarodna (CC BY 4.0)
Datum i vrijeme pohrane2024-11-14 11:53:29