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Znanstveni rad - Prikaz slučaja
Combined megaloblastic and immunohemolytic anemia associated - case report
Acta clinica Croatica, 47 (2008), 4; 239-243. urn:nbn:hr:220:047445
Vucelić, Vesna; Stančić, Vladimir; Ledinsky, Mario; Getaldić, Biserka; Sović, Dragica; Dodig, Javorka; Grbac, Ljiljana; Gaćina, Petar; Rinčić, Goran; Čaržavec, Dubravka

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Vucelić, V., Stančić, V., Ledinsky, M., Getaldić, B., Sović, D., Dodig, J. ... Čaržavec, D. (2008). Combined megaloblastic and immunohemolytic anemia associated - case report. Acta clinica Croatica, 47. (4), 239-243. Preuzeto s https://urn.nsk.hr/urn:nbn:hr:220:047445

Vucelić, Vesna, et al. "Combined megaloblastic and immunohemolytic anemia associated - case report." Acta clinica Croatica, vol. 47, br. 4, 2008, str. 239-243. https://urn.nsk.hr/urn:nbn:hr:220:047445

Vucelić, Vesna, Vladimir Stančić, Mario Ledinsky, Biserka Getaldić, Dragica Sović, Javorka Dodig, Ljiljana Grbac, Petar Gaćina, Goran Rinčić i Dubravka Čaržavec. "Combined megaloblastic and immunohemolytic anemia associated - case report." Acta clinica Croatica 47, br. 4 (2008): 239-243. https://urn.nsk.hr/urn:nbn:hr:220:047445

Vucelić, V., et al. (2008) 'Combined megaloblastic and immunohemolytic anemia associated - case report', Acta clinica Croatica, 47(4), str. 239-243. Preuzeto s: https://urn.nsk.hr/urn:nbn:hr:220:047445 (Datum pristupa: 17.11.2024.)

Vucelić V, Stančić V, Ledinsky M, Getaldić B, Sović D, Dodig J, i sur.. Combined megaloblastic and immunohemolytic anemia associated - case report. Acta clinica Croatica [Internet]. 2008. [pristupljeno 17.11.2024.];47(4):239-243. Dostupno na: https://urn.nsk.hr/urn:nbn:hr:220:047445

V. Vucelić, et al., "Combined megaloblastic and immunohemolytic anemia associated - case report", Acta clinica Croatica, vol. 47, br. 4, str. 239-243, 2008. [Online]. Dostupno na: https://urn.nsk.hr/urn:nbn:hr:220:047445. [Citirano: 17.11.2024.]

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Naslov (engleski)Combined megaloblastic and immunohemolytic anemia associated - case report
AutorVesna Vucelić
AutorVladimir Stančić
AutorMario Ledinsky
AutorBiserka Getaldić
AutorDragica Sović
AutorJavorka Dodig
AutorLjiljana Grbac
AutorPetar Gaćina
AutorGoran Rinčić
AutorDubravka Čaržavec
Autorova ustanova(Klinički bolnički centar Sestre milosrdnice)
Znanstveno / umjetničko
područje, polje i grana		BIOMEDICINA I ZDRAVSTVO
Kliničke medicinske znanosti
Interna medicina
Sažetak (engleski)
A 55-year-old female with a history of psychosis and rheumatoid arthritis was admitted to the hospital for fatigue and dizziness. At admission, macrocytic anemia, high serum lactic acid dehydrogenase (LDH) and gastrin concentrations, decreased serum vitamin B concentration, with macroovalocytes and poikilocytes in peripheral blood smear suggested the diagnosis of pernicious anemia. Indirect antiglobulin test (IAT) was negative. Surprisingly, treatment by vitamin B and folic acid administered for two weeks was ineffective and followed by transitory worsening of hemoglobin concentration on day 8. Repeat direct antiglobulin test (DAT) and IAT were positive. This immunotransfusion conversion, suggesting the presence of autoimmune hemolytic anemia, could be explained by change in the macroblastic erythrocyte population, i.e. emerging red cells with completely exposed membrane antigens due to vitamin B treatment and/or higher degree of dysregulation of the lymphocyte clone secreting erythrocyte autoantibodies. We proposed the coexistence of pernicious and autoimmune hemolytic anemia; therefore, methylprednisolone was added to vitamin B treatment. This therapy successfully improved hemoglobin and erythrocyte concentration. Although megaloblastic-pernicious anemia is a common disease, association of pernicious and autoimmune hemolytic anemia with two mechanisms of hemolysis (ineffective erythropoiesis and immune mechanism) is a rare condition, with only several dozens of cases described so far.
Ključne riječi (engleski)
Jezikengleski
Vrsta publikacijeZnanstveni rad - Prikaz slučaja
Status objaveObjavljen
Vrsta recenzijeRecenziran - međunarodna recenzija
Verzija publikacijeObjavljena verzija rada (izdavačev PDF)
Naslov časopisaActa clinica Croatica
Brojčani podacivol. 47, br. 4, str. 239-243
p-ISSN0353-9466
e-ISSN1333-9451
URN:NBNurn:nbn:hr:220:047445
Datum objave publikacije2008
URL dokumentahttps://hrcak.srce.hr/34886
Vrsta resursaTekst
Prava pristupaOtvoreni pristup
Uvjeti korištenjaIkona licence Imenovanje-Nekomercijalno-Bez prerada 3.0 (CC BY-NC-ND 3.0)
Datum i vrijeme pohrane2022-08-31 10:34:43