prikaz prve stranice dokumenta Rapid Decrease in High Titer of Factor VIII Inhibitors upon Immunosuppressive Treatment in Severe Postpartum Acquired Hemophilia A
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Rapid Decrease in High Titer of Factor VIII Inhibitors upon Immunosuppressive Treatment in Severe Postpartum Acquired Hemophilia A
Croatian Medical Journal, 45 (2004), 2; 213-216. urn:nbn:hr:220:082211
Pejša, Vlatko; Grgurević, Ivica; Kušec, Rajko; Gaćina, Petar

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Pejša, V., Grgurević, I., Kušec, R. i Gaćina, P. (2004). Rapid Decrease in High Titer of Factor VIII Inhibitors upon Immunosuppressive Treatment in Severe Postpartum Acquired Hemophilia A. Croatian Medical Journal, 45. (2), 213-216. Preuzeto s https://urn.nsk.hr/urn:nbn:hr:220:082211

Pejša, Vlatko, et al. "Rapid Decrease in High Titer of Factor VIII Inhibitors upon Immunosuppressive Treatment in Severe Postpartum Acquired Hemophilia A." Croatian Medical Journal, vol. 45, br. 2, 2004, str. 213-216. https://urn.nsk.hr/urn:nbn:hr:220:082211

Pejša, Vlatko, Ivica Grgurević, Rajko Kušec i Petar Gaćina. "Rapid Decrease in High Titer of Factor VIII Inhibitors upon Immunosuppressive Treatment in Severe Postpartum Acquired Hemophilia A." Croatian Medical Journal 45, br. 2 (2004): 213-216. https://urn.nsk.hr/urn:nbn:hr:220:082211

Pejša, V., et al. (2004) 'Rapid Decrease in High Titer of Factor VIII Inhibitors upon Immunosuppressive Treatment in Severe Postpartum Acquired Hemophilia A', Croatian Medical Journal, 45(2), str. 213-216. Preuzeto s: https://urn.nsk.hr/urn:nbn:hr:220:082211 (Datum pristupa: 08.12.2024.)

Pejša V, Grgurević I, Kušec R, Gaćina P. Rapid Decrease in High Titer of Factor VIII Inhibitors upon Immunosuppressive Treatment in Severe Postpartum Acquired Hemophilia A. Croatian Medical Journal [Internet]. 2004. [pristupljeno 08.12.2024.];45(2):213-216. Dostupno na: https://urn.nsk.hr/urn:nbn:hr:220:082211

V. Pejša, I. Grgurević, R. Kušec i P. Gaćina, "Rapid Decrease in High Titer of Factor VIII Inhibitors upon Immunosuppressive Treatment in Severe Postpartum Acquired Hemophilia A", Croatian Medical Journal, vol. 45, br. 2, str. 213-216, 2004. [Online]. Dostupno na: https://urn.nsk.hr/urn:nbn:hr:220:082211. [Citirano: 08.12.2024.]

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Naslov (engleski)Rapid Decrease in High Titer of Factor VIII Inhibitors upon Immunosuppressive Treatment in Severe Postpartum Acquired Hemophilia A
AutorVlatko Pejša
AutorIvica Grgurević
AutorRajko Kušec
AutorPetar Gaćina
Autorova ustanova(Klinički bolnički centar Sestre milosrdnice)
Znanstveno / umjetničko
područje, polje i grana		BIOMEDICINA I ZDRAVSTVO
Kliničke medicinske znanosti
Interna medicina
Sažetak (engleski)
A 25-year-old woman was diagnosed with acquired hemophilia caused by factor VIII (FVIII) inhibitors two months after normal delivery of her first child. She presented with severe spontaneous bleeding in the right forearm and distal part of the right leg. After venipuncture for diagnostic purposes, severe hematoma developed, affecting the whole left arm and shoulder. The diagnosis of acquired hemophilia was confirmed by the presence of FVIII inhibitors (Bethesda units=76), low activity of factor VIII (5%), and prolonged activated partial thromboplastin time (APTT=89 s). The treatment with fresh frozen plasma, cryoprecipitate, red blood cells concentrate, methylprednisolone (3 mg/kg/day for 8 days, then 1mg/kg/day), and cyclophosphamide (150 mg/day for 5 days, then 100 mg/day)was followed by the regression of hematomas and normalization of APTT and FVIII activity. The titer of FVIII inhibitors rapidly decreased and total disappearance of antibodies was achieved after 15 days. To the best of our knowledge, this is the shortest time to the disappearance of inhibitors to FVIII in postpartum acquired hemophilia ever reported. Transient reappearance of inhibitors occurred 10months later and also promptly reacted to the same therapy. In the follow-up period of 4 years, the patient had two more pregnancies with no clinical and laboratory signs of illness recurrence. This case indicates important role of immunosuppressive therapy, which can rapidly induce a remission of this rare condition and be life-saving if introduced early in the course of illness and in doses higher than usually recommended.
Ključne riječi (engleski)
Jezikengleski
Vrsta publikacijeZnanstveni rad - Prikaz slučaja
Status objaveObjavljen
Vrsta recenzijeRecenziran
Verzija publikacijeObjavljena verzija rada (izdavačev PDF)
Naslov časopisaCroatian Medical Journal
Brojčani podacivol. 45, br. 2, str. 213-216
p-ISSN0353-9504
e-ISSN1332-8166
URN:NBNurn:nbn:hr:220:082211
Datum objave publikacije2004
URL dokumentahttp://www.cmj.hr/2004/45/2/15103761.htm
Vrsta resursaTekst
Prava pristupaOtvoreni pristup
Uvjeti korištenjaIkona licence Imenovanje-Nekomercijalno-Bez prerada 4.0 međunarodna (CC BY-NC-ND 4.0)
Datum i vrijeme pohrane2023-01-16 11:01:28